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Selenium: A Trace Element for a Healthy Skeleton - A Narrative Review.
Endocr Metab Immune Disord Drug Targets. 2020 Jun 27 [Online ahead of print]EM

Abstract

Inadequate serum selenium levels may delay the growth and the physiological changes in bone metabolism. In humans, reduced serum selenium concentrations are associated with both increased bone turnover and reduced bone mineral density. Moreover, a reduced nutritional intake of selenium may lead to an increased risk of bone disease. Therefore, selenium is an essential nutrient playing a role in bone health, probably due to specific selenium-proteins. Some selenium-proteins have an anti-oxidation enzymatic activity and participate in maintaining the redox cellular balance, regulating inflammation and proliferation/differentiation of bone cells too. At least nine selenium-proteins are known to be expressed by fetal osteoblasts and appear to protect bone cells from oxidative stress at bone microenvironment. Mutations of selenium-proteins and reduced circulating levels of selenium are known to be associated with skeletal diseases such as the Kashin-Beck osteoarthropathy and postmenopausal osteoporosis. In addition, the intake of selenium appears to be inversely related to the risk of hip fragility fractures. Recent data suggest that an altered selenium state may affect bone mass even in males and seleniumproteins and selenium concentrations were positively associated with the bone mass at femoral, total and trochanteric site. However, selenium, but not selenium-proteins, seems to be associated with femoral neck bone mass after adjustment for many bone fracture risk factors. The present review summarizes the findings of observational and interventional studies, which have been designed for investigating the relationship between selenium and bone metabolism.

Authors+Show Affiliations

Endocrinology and Metabolism Unit, University-Hospital S. Maria della Misericordia of Udine, 33100 Udine. Italy.Istituto Auxologico Italiano, IRCCS, Unit for Bone Metabolism Diseases and Diabetes & Lab of Endocrine and Metabolic Research, Milan. Italy.Unit of Endocrinology and diabetes, Campus Bio-Medico University, 00128 Rome. Italy.Unit of Metabolic Diseases, Department of Internal Medicine, Santa Maria Goretti Hospital, Latina. Italy.Department of Internal Medicine-Endocrinology "Policlinico Morgagni", Catania. Italy.Endocrinology Unit, "Casa Sollievo della Sofferenza" IRCCS-Hospital, San Giovanni Rotondo. Italy.Department of Medicine, Surgery and Neurosciences, University of Siena, Siena. Italy.Istituto Auxologico Italiano, IRCCS, Unit for Bone Metabolism Diseases and Diabetes & Lab of Endocrine and Metabolic Research, Milan. Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32600242

Citation

Vescini, Fabio, et al. "Selenium: a Trace Element for a Healthy Skeleton - a Narrative Review." Endocrine, Metabolic & Immune Disorders Drug Targets, 2020.
Vescini F, Chiodini I, Palermo A, et al. Selenium: A Trace Element for a Healthy Skeleton - A Narrative Review. Endocr Metab Immune Disord Drug Targets. 2020.
Vescini, F., Chiodini, I., Palermo, A., Cesareo, R., De Geronimo, V., Scillitani, A., Gennari, L., & Falchetti, A. (2020). Selenium: A Trace Element for a Healthy Skeleton - A Narrative Review. Endocrine, Metabolic & Immune Disorders Drug Targets. https://doi.org/10.2174/1871530320666200628030913
Vescini F, et al. Selenium: a Trace Element for a Healthy Skeleton - a Narrative Review. Endocr Metab Immune Disord Drug Targets. 2020 Jun 27; PubMed PMID: 32600242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium: A Trace Element for a Healthy Skeleton - A Narrative Review. AU - Vescini,Fabio, AU - Chiodini,Iacopo, AU - Palermo,Andrea, AU - Cesareo,Roberto, AU - De Geronimo,Vincenzo, AU - Scillitani,Alfredo, AU - Gennari,Luigi, AU - Falchetti,Alberto, Y1 - 2020/06/27/ PY - 2020/01/15/received PY - 2020/05/06/revised PY - 2020/05/06/accepted PY - 2020/7/1/entrez KW - Selenium KW - anti-oxidation activity KW - bone metabolism KW - bone turnover KW - inflammation KW - osteoclasts JF - Endocrine, metabolic & immune disorders drug targets JO - Endocr Metab Immune Disord Drug Targets N2 - Inadequate serum selenium levels may delay the growth and the physiological changes in bone metabolism. In humans, reduced serum selenium concentrations are associated with both increased bone turnover and reduced bone mineral density. Moreover, a reduced nutritional intake of selenium may lead to an increased risk of bone disease. Therefore, selenium is an essential nutrient playing a role in bone health, probably due to specific selenium-proteins. Some selenium-proteins have an anti-oxidation enzymatic activity and participate in maintaining the redox cellular balance, regulating inflammation and proliferation/differentiation of bone cells too. At least nine selenium-proteins are known to be expressed by fetal osteoblasts and appear to protect bone cells from oxidative stress at bone microenvironment. Mutations of selenium-proteins and reduced circulating levels of selenium are known to be associated with skeletal diseases such as the Kashin-Beck osteoarthropathy and postmenopausal osteoporosis. In addition, the intake of selenium appears to be inversely related to the risk of hip fragility fractures. Recent data suggest that an altered selenium state may affect bone mass even in males and seleniumproteins and selenium concentrations were positively associated with the bone mass at femoral, total and trochanteric site. However, selenium, but not selenium-proteins, seems to be associated with femoral neck bone mass after adjustment for many bone fracture risk factors. The present review summarizes the findings of observational and interventional studies, which have been designed for investigating the relationship between selenium and bone metabolism. SN - 2212-3873 UR - https://www.unboundmedicine.com/medline/citation/32600242/Selenium:_A_Trace_Element_for_a_Healthy_Skeleton_-_A_Narrative_Review L2 - http://www.eurekaselect.com/183225/article DB - PRIME DP - Unbound Medicine ER -
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