Tags

Type your tag names separated by a space and hit enter

The impact of COVID-19 on ischemic stroke.
Diagn Pathol. 2020 Jun 29; 15(1):78.DP

Abstract

BACKGROUND

The outbreak of a novel coronavirus since December 2019, became an emergency of major international concern. As of June 21, 2020, the SARS-CoV-2 pandemic has caused 8,769,844 confirmed infections with 463,745 fatal cases worldwide. The SARS-CoV-2 outbreak is a major challenge for clinicians. In our clinic, we found a rare case that a COVID-19 patient combined with ischemic stroke.

CASE PRESENTATION

A 79-year-old man was admitted to the Hubei Provincial Hospital of Traditional Chinese Medicine due to right limb weakness for 1 day and slight cough for 1 week. At presentation, his oxygen saturation was 94.2% on room air and body temperature was 37.3 °C (99.0 °F) with some moist rales. Neurological examination showed right limb weakness, and the limb muscle strength was grade 4. The left leg and arms were unaffected. In addition, runs of speech were not fluent enough with tongue deviation. Laboratory studies showed lymphopenia and eosinophilic granulocytopenia. Chest CT revealed bilateral pulmonary parenchymal ground-glass and consolidative pulmonary opacities, with a peripheral lung distribution. Real-time polymerase chain reaction (RT-PCR) from throat swab sample was positive for SARS-CoV-2 nucleic acid. This patient was treated with antiviral drugs and anti-inflammatory drugs with supportive care until his discharge. Clopidogrel (75 mg) and atorvastatin (20 mg) were administered orally to treat acute ischemic stroke. After 12 days of treatment, he can walk normally and communicate with near fluent language.

CONCLUSION

We report an even more unusual case, a patient who was hospitalized for right limb weakness and was later diagnosed with COVID-19. Here, SARS-CoV-2 infection caused hypoxemia and excessive secretion of inflammatory cytokines, which contribute to the occurrence and development of ischemic stroke. Once COVID-19 patients show acute ischemic stroke, neurologists should cooperate with infectious disease doctors to help patients.

Authors+Show Affiliations

Department of Neurology, Hubei Provincial Hospital of Tradition Chinese Medicine, Wuhan, 430073, Hubei, China.Department of Neurology, Hubei Provincial Hospital of Tradition Chinese Medicine, Wuhan, 430073, Hubei, China.Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, Hubei, China. lym-fly@whu.edu.cn.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32600350

Citation

Zhai, Pan, et al. "The Impact of COVID-19 On Ischemic Stroke." Diagnostic Pathology, vol. 15, no. 1, 2020, p. 78.
Zhai P, Ding Y, Li Y. The impact of COVID-19 on ischemic stroke. Diagn Pathol. 2020;15(1):78.
Zhai, P., Ding, Y., & Li, Y. (2020). The impact of COVID-19 on ischemic stroke. Diagnostic Pathology, 15(1), 78. https://doi.org/10.1186/s13000-020-00994-0
Zhai P, Ding Y, Li Y. The Impact of COVID-19 On Ischemic Stroke. Diagn Pathol. 2020 Jun 29;15(1):78. PubMed PMID: 32600350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of COVID-19 on ischemic stroke. AU - Zhai,Pan, AU - Ding,Yanbing, AU - Li,Yiming, Y1 - 2020/06/29/ PY - 2020/04/06/received PY - 2020/06/19/accepted PY - 2020/7/1/entrez PY - 2020/7/1/pubmed PY - 2020/7/9/medline KW - COVID-19 KW - Case report KW - Hypoxemia KW - Ischemic stroke KW - SARS-CoV-2 SP - 78 EP - 78 JF - Diagnostic pathology JO - Diagn Pathol VL - 15 IS - 1 N2 - BACKGROUND: The outbreak of a novel coronavirus since December 2019, became an emergency of major international concern. As of June 21, 2020, the SARS-CoV-2 pandemic has caused 8,769,844 confirmed infections with 463,745 fatal cases worldwide. The SARS-CoV-2 outbreak is a major challenge for clinicians. In our clinic, we found a rare case that a COVID-19 patient combined with ischemic stroke. CASE PRESENTATION: A 79-year-old man was admitted to the Hubei Provincial Hospital of Traditional Chinese Medicine due to right limb weakness for 1 day and slight cough for 1 week. At presentation, his oxygen saturation was 94.2% on room air and body temperature was 37.3 °C (99.0 °F) with some moist rales. Neurological examination showed right limb weakness, and the limb muscle strength was grade 4. The left leg and arms were unaffected. In addition, runs of speech were not fluent enough with tongue deviation. Laboratory studies showed lymphopenia and eosinophilic granulocytopenia. Chest CT revealed bilateral pulmonary parenchymal ground-glass and consolidative pulmonary opacities, with a peripheral lung distribution. Real-time polymerase chain reaction (RT-PCR) from throat swab sample was positive for SARS-CoV-2 nucleic acid. This patient was treated with antiviral drugs and anti-inflammatory drugs with supportive care until his discharge. Clopidogrel (75 mg) and atorvastatin (20 mg) were administered orally to treat acute ischemic stroke. After 12 days of treatment, he can walk normally and communicate with near fluent language. CONCLUSION: We report an even more unusual case, a patient who was hospitalized for right limb weakness and was later diagnosed with COVID-19. Here, SARS-CoV-2 infection caused hypoxemia and excessive secretion of inflammatory cytokines, which contribute to the occurrence and development of ischemic stroke. Once COVID-19 patients show acute ischemic stroke, neurologists should cooperate with infectious disease doctors to help patients. SN - 1746-1596 UR - https://www.unboundmedicine.com/medline/citation/32600350/The_impact_of_COVID-19_on_ischemic_stroke L2 - https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-020-00994-0 DB - PRIME DP - Unbound Medicine ER -