Tags

Type your tag names separated by a space and hit enter

Association between obesity and clinical prognosis in patients infected with SARS-CoV-2.
Infect Dis Poverty. 2020 Jun 29; 9(1):80.ID

Abstract

BACKGROUND

It is well established that obesity is a disease of sustained low-grade inflammation. However, it is currently unknown if obesity plays a role in the clinical manifestations and prognosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. In this study, we aimed to investigate whether obesity played a role in clinical manifestations and prognosis in patients infected with SARS-CoV-2.

METHODS

This is a retrospective multicenter clinical study. A total of 96 patients hospitalized with SARS-CoV-2 infection were enrolled from Dongguan People's Hospital, Nanfang hospital and the First Affiliated Hospital of Xiamen University between 23 January and 14 February 2020. Demographic and clinical data were extracted from medical records. Acute respiratory distress syndrome (ARDS) was defined as oxygenation index (PaO2/FiO2) ≤ 300 mmHg. We grouped patients through the body mass index (BMI). Associations were examined using the t test, χ2 test and multivariate logistic forward regression test.

RESULTS

Patients with BMI < 24 were significantly younger (P = 0.025) with lower creatine kinase (P = 0.013), lower diastolic pressure blood (P = 0.035), lower serum creatinine (P = 0.012), lower lactate dehydrogenase (P = 0.001) and higher platelet count (P = 0.002). The BMI level was 20.78 ± 3.15 in patients without pneumonia compared with the patients with pneumonia (23.81 ± 3.49, P = 0.001). For patients without ARDS, an average BMI level of 22.65 ± 3.53 was observed, significantly lower than patients with ARDS (24.57 ± 3.59, P = 0.022). The mean BMI was 22.35 ± 3.56 in patients experienced with relieving the clinical symptoms or stable condition by radiographic tests, lower than patients with disease exacerbation with 24.89 ± 3.17 (P = 0.001). In addition, lymphocyte count (r = - 0.23, P = 0.027) and platelet count (r = - 0.44, P < 0.001) were negatively correlated with BMI. While hemoglobin (r = 0.267, P = 0.008), creatine kinase (r = 0.331, P = 0.001), serum creatinine (r = 0.424, P < 0.001) and lactate dehydrogenase (r = 0.343, P = 0.001) were significantly positive correlated with BMI. Multivariate analysis showed that older age (OR = 1.046, P = 0.009) and BMI ≥ 24 (OR = 1.258, P = 0.005) were independent risk factors associated ICU admission while BMI ≥ 24 (OR = 4.219, P = 0.007) was independent risk factor associated with radiographic disease exacerbation.

CONCLUSIONS

Our study found BMI was significantly associated with clinical manifestations and prognosis of patients with SARS-CoV-2 infection. For patients with increased risk, clinicians should intervene promptly to avoid disease progression.

Authors+Show Affiliations

Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China. shaohangcai@foxmail.com.Intensive Care Unit, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China. Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong Province, China.Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong Province, China. Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China.Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong Province, China. Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China.Emergency Department, First Affiliated Hospital of Xiamen University, Xiamen, Fujian province, China.Department of Infectious Diseases, Dongguan people's Hospital, Southern Medical University, Dongguan, Guangdong Province, China. 385338012@qq.com.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

32600411

Citation

Cai, Shao-Hang, et al. "Association Between Obesity and Clinical Prognosis in Patients Infected With SARS-CoV-2." Infectious Diseases of Poverty, vol. 9, no. 1, 2020, p. 80.
Cai SH, Liao W, Chen SW, et al. Association between obesity and clinical prognosis in patients infected with SARS-CoV-2. Infect Dis Poverty. 2020;9(1):80.
Cai, S. H., Liao, W., Chen, S. W., Liu, L. L., Liu, S. Y., & Zheng, Z. D. (2020). Association between obesity and clinical prognosis in patients infected with SARS-CoV-2. Infectious Diseases of Poverty, 9(1), 80. https://doi.org/10.1186/s40249-020-00703-5
Cai SH, et al. Association Between Obesity and Clinical Prognosis in Patients Infected With SARS-CoV-2. Infect Dis Poverty. 2020 Jun 29;9(1):80. PubMed PMID: 32600411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between obesity and clinical prognosis in patients infected with SARS-CoV-2. AU - Cai,Shao-Hang, AU - Liao,Wei, AU - Chen,Shu-Wei, AU - Liu,Li-Li, AU - Liu,Si-Yao, AU - Zheng,Zhi-Dan, Y1 - 2020/06/29/ PY - 2020/03/03/received PY - 2020/06/16/accepted PY - 2020/7/1/entrez PY - 2020/7/1/pubmed PY - 2020/7/9/medline KW - Acute respiratory distress syndrome KW - Body mass index KW - Obesity KW - Pneumonia KW - Prognosis KW - SARS-CoV-2 SP - 80 EP - 80 JF - Infectious diseases of poverty JO - Infect Dis Poverty VL - 9 IS - 1 N2 - BACKGROUND: It is well established that obesity is a disease of sustained low-grade inflammation. However, it is currently unknown if obesity plays a role in the clinical manifestations and prognosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. In this study, we aimed to investigate whether obesity played a role in clinical manifestations and prognosis in patients infected with SARS-CoV-2. METHODS: This is a retrospective multicenter clinical study. A total of 96 patients hospitalized with SARS-CoV-2 infection were enrolled from Dongguan People's Hospital, Nanfang hospital and the First Affiliated Hospital of Xiamen University between 23 January and 14 February 2020. Demographic and clinical data were extracted from medical records. Acute respiratory distress syndrome (ARDS) was defined as oxygenation index (PaO2/FiO2) ≤ 300 mmHg. We grouped patients through the body mass index (BMI). Associations were examined using the t test, χ2 test and multivariate logistic forward regression test. RESULTS: Patients with BMI < 24 were significantly younger (P = 0.025) with lower creatine kinase (P = 0.013), lower diastolic pressure blood (P = 0.035), lower serum creatinine (P = 0.012), lower lactate dehydrogenase (P = 0.001) and higher platelet count (P = 0.002). The BMI level was 20.78 ± 3.15 in patients without pneumonia compared with the patients with pneumonia (23.81 ± 3.49, P = 0.001). For patients without ARDS, an average BMI level of 22.65 ± 3.53 was observed, significantly lower than patients with ARDS (24.57 ± 3.59, P = 0.022). The mean BMI was 22.35 ± 3.56 in patients experienced with relieving the clinical symptoms or stable condition by radiographic tests, lower than patients with disease exacerbation with 24.89 ± 3.17 (P = 0.001). In addition, lymphocyte count (r = - 0.23, P = 0.027) and platelet count (r = - 0.44, P < 0.001) were negatively correlated with BMI. While hemoglobin (r = 0.267, P = 0.008), creatine kinase (r = 0.331, P = 0.001), serum creatinine (r = 0.424, P < 0.001) and lactate dehydrogenase (r = 0.343, P = 0.001) were significantly positive correlated with BMI. Multivariate analysis showed that older age (OR = 1.046, P = 0.009) and BMI ≥ 24 (OR = 1.258, P = 0.005) were independent risk factors associated ICU admission while BMI ≥ 24 (OR = 4.219, P = 0.007) was independent risk factor associated with radiographic disease exacerbation. CONCLUSIONS: Our study found BMI was significantly associated with clinical manifestations and prognosis of patients with SARS-CoV-2 infection. For patients with increased risk, clinicians should intervene promptly to avoid disease progression. SN - 2049-9957 UR - https://www.unboundmedicine.com/medline/citation/32600411/Association_between_obesity_and_clinical_prognosis_in_patients_infected_with_SARS_CoV_2_ L2 - https://idpjournal.biomedcentral.com/articles/10.1186/s40249-020-00703-5 DB - PRIME DP - Unbound Medicine ER -