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The role of preoperative albumin to globulin ratio in predicting prognosis in testicular cancer patients.
Actas Urol Esp. 2020 Jun 26 [Online ahead of print]AU

Abstract

INTRODUCTION AND OBJECTIVES

In recent years, the incidence of testicular cancer has increased, but mortality rates have decreased thanks to the improvements in treatment. Although primary tumor characteristics and serum tumor markers are associated with metastasis and relapse, their predictive value is not reliable. Therefore, there is a need for new biomarkers that predict prognosis. In this study, we aimed to investigate the role of preoperative albumin to globulin ratio (AGR) in predicting retroperitoneal lymph node (RPLN) involvement, distant metastasis and prognosis in testicular cancer.

MATERIAL AND METHODS

We retrospectively analyzed the medical records of all patients that underwent radical inguinal orchiectomy at our hospital between 2007 and 2018. AGR was calculated using the equation: AGR=serum albumin/(serum total protein-serum albumin). The predictive value of AGR for RPLN involvement and distant metastasis was evaluated using receiver operating characteristic analysis and its prognostic value was evaluated using Kaplan-Meier survival analysis.

RESULTS

A total of 115 patients with a mean age of 33.4±7.7years were included in the study. In multivariate analysis, AGR less than 1.47 and the presence of lymphovascular invasion were detected as the factors predicting RPLN involvement and distant metastasis. The AGR of patients who had died was significantly lower than AGR of those who were alive, 1±0.2 versus 1.6±0.3 (P=.001). In Kaplan-Meier survival analysis, the mean survival of patients with higher AGR (>1.47) was found longer than patients with lower AGR (<1.47).

CONCLUSIONS

Preoperative AGR is a biomarker that may be used in predicting RPLN involvement, distant metastasis and prognosis in testicular cancer.

Authors+Show Affiliations

Department of Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Estambul, Turquía. Electronic address: ekremguner@yahoo.com.Department of Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Estambul, Turquía.

Pub Type(s)

Journal Article

Language

eng spa

PubMed ID

32600877

Citation

Guner, E, and K G. Seker. "The Role of Preoperative Albumin to Globulin Ratio in Predicting Prognosis in Testicular Cancer Patients." Actas Urologicas Espanolas, 2020.
Guner E, Seker KG. The role of preoperative albumin to globulin ratio in predicting prognosis in testicular cancer patients. Actas Urol Esp. 2020.
Guner, E., & Seker, K. G. (2020). The role of preoperative albumin to globulin ratio in predicting prognosis in testicular cancer patients. Actas Urologicas Espanolas. https://doi.org/10.1016/j.acuro.2020.03.011
Guner E, Seker KG. The Role of Preoperative Albumin to Globulin Ratio in Predicting Prognosis in Testicular Cancer Patients. Actas Urol Esp. 2020 Jun 26; PubMed PMID: 32600877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of preoperative albumin to globulin ratio in predicting prognosis in testicular cancer patients. AU - Guner,E, AU - Seker,K G, Y1 - 2020/06/26/ PY - 2020/01/13/received PY - 2020/03/09/revised PY - 2020/03/22/accepted PY - 2020/7/1/entrez KW - Albumin KW - Albumin to globulin ratio KW - Albúmina KW - Cáncer testicular KW - Globulin KW - Globulina KW - Prognosis KW - Pronóstico KW - Relación albúmina/globulina KW - Testicular cancer JF - Actas urologicas espanolas JO - Actas Urol Esp N2 - INTRODUCTION AND OBJECTIVES: In recent years, the incidence of testicular cancer has increased, but mortality rates have decreased thanks to the improvements in treatment. Although primary tumor characteristics and serum tumor markers are associated with metastasis and relapse, their predictive value is not reliable. Therefore, there is a need for new biomarkers that predict prognosis. In this study, we aimed to investigate the role of preoperative albumin to globulin ratio (AGR) in predicting retroperitoneal lymph node (RPLN) involvement, distant metastasis and prognosis in testicular cancer. MATERIAL AND METHODS: We retrospectively analyzed the medical records of all patients that underwent radical inguinal orchiectomy at our hospital between 2007 and 2018. AGR was calculated using the equation: AGR=serum albumin/(serum total protein-serum albumin). The predictive value of AGR for RPLN involvement and distant metastasis was evaluated using receiver operating characteristic analysis and its prognostic value was evaluated using Kaplan-Meier survival analysis. RESULTS: A total of 115 patients with a mean age of 33.4±7.7years were included in the study. In multivariate analysis, AGR less than 1.47 and the presence of lymphovascular invasion were detected as the factors predicting RPLN involvement and distant metastasis. The AGR of patients who had died was significantly lower than AGR of those who were alive, 1±0.2 versus 1.6±0.3 (P=.001). In Kaplan-Meier survival analysis, the mean survival of patients with higher AGR (>1.47) was found longer than patients with lower AGR (<1.47). CONCLUSIONS: Preoperative AGR is a biomarker that may be used in predicting RPLN involvement, distant metastasis and prognosis in testicular cancer. SN - 1699-7980 UR - https://www.unboundmedicine.com/medline/citation/32600877/The_role_of_preoperative_albumin_to_globulin_ratio_in_predicting_prognosis_in_testicular_cancer_patients L2 - https://linkinghub.elsevier.com/retrieve/pii/S0210-4806(20)30127-3 DB - PRIME DP - Unbound Medicine ER -
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