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Eicosanoids seasonally impact pulmonary function in asthmatic patients with Japanese cedar pollinosis.
Allergol Int. 2020 Oct; 69(4):594-600.AI

Abstract

BACKGROUND

Condition of asthma in patients with asthma and concomitant seasonal allergic rhinitis (SAR) deteriorates during the Japanese cedar pollen (JCP) season. However, the underlying mechanisms remain unclear.

METHODS

We analyzed seasonal variations in eicosanoid levels in the airways of patients with asthma and concomitant SAR sensitized to JCP (N = 29, BA-SAR-JCP group) and those not sensitized (N = 13, BA-AR-non-JCP group) during the JCP season. The association between changes in eicosanoid concentrations and pulmonary function was assessed. Exhaled breath condensate (EBC) was collected, and pulmonary function tests were performed during the JCP and non-JCP seasons. The cysteinyl leukotriene (CysLT), thromboxane B2 (TXB2), prostaglandin D2-methoxime (PGD2-MOX), and leukotriene B4 (LTB4) levels in the collected EBC were measured via enzyme-linked immunosorbent immunoassays.

RESULTS

The log CysLT levels significantly increased in the BA-SAR-JCP group during the JCP season compared with the non-JCP season (1.78 ± 0.55, 1.39 ± 0.63 pg/mL, mean ± standard deviation, respectively, p = 0.01) and those in the BA-AR-non-JCP group during the JCP season (1.39 ± 0.38 pg/mL, p = 0.04). Moreover, the log TXB2 levels seemed to increase. However, the log LTB4 and log PGD2-MOX levels did not increase. The changes in the log CysLT levels during the two seasons were negatively correlated to forced expiratory volume in one second (FEV1) in the BA-SAR-JCP group (r = -0.52, p < 0.01).

CONCLUSIONS

In the BA-SAR-JCP group, seasonal increases in eicosanoid levels in the airway likely promoted deterioration in pulmonary function despite optimal maintenance treatment.

Authors+Show Affiliations

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University, Saitama, Japan. Electronic address: tsoma@saitama-med.ac.jp.Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University, Saitama, Japan.Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University, Saitama, Japan.Allergy Center, Saitama Medical University, Saitama, Japan; Hoshi Clinic, Saitama, Japan.Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University, Saitama, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32600924

Citation

Soma, Tomoyuki, et al. "Eicosanoids Seasonally Impact Pulmonary Function in Asthmatic Patients With Japanese Cedar Pollinosis." Allergology International : Official Journal of the Japanese Society of Allergology, vol. 69, no. 4, 2020, pp. 594-600.
Soma T, Uchida Y, Nakagome K, et al. Eicosanoids seasonally impact pulmonary function in asthmatic patients with Japanese cedar pollinosis. Allergol Int. 2020;69(4):594-600.
Soma, T., Uchida, Y., Nakagome, K., Hoshi, R., & Nagata, M. (2020). Eicosanoids seasonally impact pulmonary function in asthmatic patients with Japanese cedar pollinosis. Allergology International : Official Journal of the Japanese Society of Allergology, 69(4), 594-600. https://doi.org/10.1016/j.alit.2020.04.014
Soma T, et al. Eicosanoids Seasonally Impact Pulmonary Function in Asthmatic Patients With Japanese Cedar Pollinosis. Allergol Int. 2020;69(4):594-600. PubMed PMID: 32600924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eicosanoids seasonally impact pulmonary function in asthmatic patients with Japanese cedar pollinosis. AU - Soma,Tomoyuki, AU - Uchida,Yoshitaka, AU - Nakagome,Kazuyuki, AU - Hoshi,Rie, AU - Nagata,Makoto, Y1 - 2020/06/26/ PY - 2019/08/29/received PY - 2020/03/21/revised PY - 2020/04/04/accepted PY - 2020/7/1/pubmed PY - 2020/7/1/medline PY - 2020/7/1/entrez KW - %FEV1 KW - Allergic asthma KW - Cysteinyl leukotrienes KW - Exhaled breath condensate KW - Japanese cedar pollen SP - 594 EP - 600 JF - Allergology international : official journal of the Japanese Society of Allergology JO - Allergol Int VL - 69 IS - 4 N2 - BACKGROUND: Condition of asthma in patients with asthma and concomitant seasonal allergic rhinitis (SAR) deteriorates during the Japanese cedar pollen (JCP) season. However, the underlying mechanisms remain unclear. METHODS: We analyzed seasonal variations in eicosanoid levels in the airways of patients with asthma and concomitant SAR sensitized to JCP (N = 29, BA-SAR-JCP group) and those not sensitized (N = 13, BA-AR-non-JCP group) during the JCP season. The association between changes in eicosanoid concentrations and pulmonary function was assessed. Exhaled breath condensate (EBC) was collected, and pulmonary function tests were performed during the JCP and non-JCP seasons. The cysteinyl leukotriene (CysLT), thromboxane B2 (TXB2), prostaglandin D2-methoxime (PGD2-MOX), and leukotriene B4 (LTB4) levels in the collected EBC were measured via enzyme-linked immunosorbent immunoassays. RESULTS: The log CysLT levels significantly increased in the BA-SAR-JCP group during the JCP season compared with the non-JCP season (1.78 ± 0.55, 1.39 ± 0.63 pg/mL, mean ± standard deviation, respectively, p = 0.01) and those in the BA-AR-non-JCP group during the JCP season (1.39 ± 0.38 pg/mL, p = 0.04). Moreover, the log TXB2 levels seemed to increase. However, the log LTB4 and log PGD2-MOX levels did not increase. The changes in the log CysLT levels during the two seasons were negatively correlated to forced expiratory volume in one second (FEV1) in the BA-SAR-JCP group (r = -0.52, p < 0.01). CONCLUSIONS: In the BA-SAR-JCP group, seasonal increases in eicosanoid levels in the airway likely promoted deterioration in pulmonary function despite optimal maintenance treatment. SN - 1440-1592 UR - https://www.unboundmedicine.com/medline/citation/32600924/Eicosanoids_seasonally_impact_pulmonary_function_in_asthmatic_patients_with_Japanese_cedar_pollinosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1323-8930(20)30071-X DB - PRIME DP - Unbound Medicine ER -
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