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Tumour budding and its clinical implications in gastrointestinal cancers.
Br J Cancer. 2020 Jun 30 [Online ahead of print]BJ

Abstract

Tumour budding in colorectal cancer has become an important prognostic factor. Represented by single cells or small tumour cell clusters at the invasion front of the tumour mass, these tumour buds seem to reflect cells in a 'hybrid' state of epithelial-mesenchymal transition, and evidence indicates that the presence of these entities is associated with lymph node metastasis, local recurrence and distant metastatic disease. The International Tumour Budding Consensus Conference (ITBCC) has highlighted a scoring system for the reporting of tumour budding in colorectal cancer, as well as different clinical scenarios that could affect patient management. Other organs are not spared: tumour budding has been described in numerous gastrointestinal and non-gastrointestinal cancers. Here, we give an update on ITBCC validation studies in the context of colorectal cancer and the clinical implications of tumour budding throughout the upper gastrointestinal and pancreatico-biliary tract.

Authors+Show Affiliations

Institute of Pathology, University of Bern, Bern, Switzerland. inti.zlobec@pathology.unibe.ch.Department of Medical Oncology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.Institute of Pathology, University of Bern, Bern, Switzerland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32601463

Citation

Zlobec, Inti, et al. "Tumour Budding and Its Clinical Implications in Gastrointestinal Cancers." British Journal of Cancer, 2020.
Zlobec I, Berger MD, Lugli A. Tumour budding and its clinical implications in gastrointestinal cancers. Br J Cancer. 2020.
Zlobec, I., Berger, M. D., & Lugli, A. (2020). Tumour budding and its clinical implications in gastrointestinal cancers. British Journal of Cancer. https://doi.org/10.1038/s41416-020-0954-z
Zlobec I, Berger MD, Lugli A. Tumour Budding and Its Clinical Implications in Gastrointestinal Cancers. Br J Cancer. 2020 Jun 30; PubMed PMID: 32601463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tumour budding and its clinical implications in gastrointestinal cancers. AU - Zlobec,Inti, AU - Berger,Martin D, AU - Lugli,Alessandro, Y1 - 2020/06/30/ PY - 2019/12/30/received PY - 2020/06/02/accepted PY - 2020/04/17/revised PY - 2020/7/1/entrez JF - British journal of cancer JO - Br. J. Cancer N2 - Tumour budding in colorectal cancer has become an important prognostic factor. Represented by single cells or small tumour cell clusters at the invasion front of the tumour mass, these tumour buds seem to reflect cells in a 'hybrid' state of epithelial-mesenchymal transition, and evidence indicates that the presence of these entities is associated with lymph node metastasis, local recurrence and distant metastatic disease. The International Tumour Budding Consensus Conference (ITBCC) has highlighted a scoring system for the reporting of tumour budding in colorectal cancer, as well as different clinical scenarios that could affect patient management. Other organs are not spared: tumour budding has been described in numerous gastrointestinal and non-gastrointestinal cancers. Here, we give an update on ITBCC validation studies in the context of colorectal cancer and the clinical implications of tumour budding throughout the upper gastrointestinal and pancreatico-biliary tract. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/32601463/Tumour_budding_and_its_clinical_implications_in_gastrointestinal_cancers L2 - http://dx.doi.org/10.1038/s41416-020-0954-z DB - PRIME DP - Unbound Medicine ER -
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