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Neurological Consequences of 2019-nCoV Infection: A Comprehensive Literature Review.
Cureus. 2020 Jun 24; 12(6):e8790.C

Abstract

First identified in November 2019 in Hubei Province, the coronavirus disease of 2019 (COVID-19) caused by SARS-CoV-2 soon spread worldwide to become a global health pandemic. The COVID-19 preferentially damages the respiratory system that produces symptoms such as fever, cough, and shortness of breath. However, the infection often tends to disseminate to involve various organ systems. Recent evidence indicates that SARS-CoV-2 can cause significant neurological damage and resultant neurological symptoms and complications. Here, we provide a comprehensive and thorough review of original articles, case reports, and case series to delineate the possible mechanisms of nervous system invasion and damage by SARS-CoV-2 and subsequent consequences. We divided the neurological manifestations into three categories: (1) Central Nervous System involvement, (2) Peripheral Nervous System manifestations, and (3) Skeletal Muscle Injury. Headache and dizziness were found to be the most prevalent symptoms followed by impaired consciousness. Among the symptoms indicating peripheral nervous system invasion, anosmia and dysgeusia were commonly reported. Skeletal muscle injury predominantly presents as myalgia. In addition, encephalitis, myelitis, cerebrovascular disease, Guillain-Barre syndrome, and Miller Fischer syndrome were among the commonly noted complications. We also emphasized the association of pre-existing comorbidities with neurological manifestations. The aim of this review is to provide a deeper understanding of the potential neurological implications to help neurologists have a high index of clinical suspicion allowing them to manage the patient appropriately.

Authors+Show Affiliations

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.Internal Medicine, Dow University of Health Sciences, Karachi, PAK.Internal Medicine, Dow Medical College and Dr. Ruth K. M. Pfau Civil Hospital, Karachi, PAK.Healthcare Administration, Franklin University, Columbus, USA. Medicine, Xavier University School of Medicine, Oranjestad, ABW.Medicine, Windsor University School of Medicine, Cayon, KNA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32601577

Citation

Azim, Dua, et al. "Neurological Consequences of 2019-nCoV Infection: a Comprehensive Literature Review." Cureus, vol. 12, no. 6, 2020, pp. e8790.
Azim D, Nasim S, Kumar S, et al. Neurological Consequences of 2019-nCoV Infection: A Comprehensive Literature Review. Cureus. 2020;12(6):e8790.
Azim, D., Nasim, S., Kumar, S., Hussain, A., & Patel, S. (2020). Neurological Consequences of 2019-nCoV Infection: A Comprehensive Literature Review. Cureus, 12(6), e8790. https://doi.org/10.7759/cureus.8790
Azim D, et al. Neurological Consequences of 2019-nCoV Infection: a Comprehensive Literature Review. Cureus. 2020 Jun 24;12(6):e8790. PubMed PMID: 32601577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurological Consequences of 2019-nCoV Infection: A Comprehensive Literature Review. AU - Azim,Dua, AU - Nasim,Sundus, AU - Kumar,Sohail, AU - Hussain,Azhar, AU - Patel,Sundip, Y1 - 2020/06/24/ PY - 2020/7/1/entrez PY - 2020/7/1/pubmed PY - 2020/7/1/medline KW - cerebrovascular injury KW - covid-19 KW - hypoxic injury KW - immune-mediated injury KW - sars-cov-2 SP - e8790 EP - e8790 JF - Cureus JO - Cureus VL - 12 IS - 6 N2 - First identified in November 2019 in Hubei Province, the coronavirus disease of 2019 (COVID-19) caused by SARS-CoV-2 soon spread worldwide to become a global health pandemic. The COVID-19 preferentially damages the respiratory system that produces symptoms such as fever, cough, and shortness of breath. However, the infection often tends to disseminate to involve various organ systems. Recent evidence indicates that SARS-CoV-2 can cause significant neurological damage and resultant neurological symptoms and complications. Here, we provide a comprehensive and thorough review of original articles, case reports, and case series to delineate the possible mechanisms of nervous system invasion and damage by SARS-CoV-2 and subsequent consequences. We divided the neurological manifestations into three categories: (1) Central Nervous System involvement, (2) Peripheral Nervous System manifestations, and (3) Skeletal Muscle Injury. Headache and dizziness were found to be the most prevalent symptoms followed by impaired consciousness. Among the symptoms indicating peripheral nervous system invasion, anosmia and dysgeusia were commonly reported. Skeletal muscle injury predominantly presents as myalgia. In addition, encephalitis, myelitis, cerebrovascular disease, Guillain-Barre syndrome, and Miller Fischer syndrome were among the commonly noted complications. We also emphasized the association of pre-existing comorbidities with neurological manifestations. The aim of this review is to provide a deeper understanding of the potential neurological implications to help neurologists have a high index of clinical suspicion allowing them to manage the patient appropriately. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/32601577/Neurological_Consequences_of_2019-nCoV_Infection:_A_Comprehensive_Literature_Review L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32601577/ DB - PRIME DP - Unbound Medicine ER -
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