Tags

Type your tag names separated by a space and hit enter

The accuracy of a novel sonographic scanning and reporting protocol to survey for soft tissue sarcoma local recurrence.
Skeletal Radiol. 2020 Jun 29 [Online ahead of print]SR

Abstract

OBJECTIVE

This study aims to determine the accuracy of a novel ultrasonography (US) scanning and reporting protocol to detect recurrences. The secondary aim is to compare US and MRI accuracy and agreement.

MATERIALS AND METHODS

In this IRB-approved prospective study, consecutive patients presenting for MRI surveillance after resection were enrolled and underwent same-day US. Blinded to clinical information and the MRI, the US scanner characterized lesions using a proposed novel lexicon. Outcome was defined either by histology or a subsequent MRI scan confirming the presence or absence of recurrence. Fisher's exact test and Kappa test were performed to assess of the significance and agreement between US, MRI, and outcome.

RESULTS

A total of 68 US scans were performed on 55 patients. The overall accuracy to diagnose recurrence was the same for US and MRI (92.6%) while US was less sensitive (75.0% vs. 91.7%) but more specific (97.6% vs. 92.9%) than MRI. The two lesions missed by US but not MRI were an entirely intraosseous metastasis and a subcentimeter skin nodule. There was strong agreement between US and MRI with outcome (k = 0.787 and 0.801, respectively).

CONCLUSIONS

These pilot data suggest the accuracy of this novel US local recurrence surveillance method is comparable to MRI. A multi-institutional prospective trial would increase power and determine reproducibility.

Authors+Show Affiliations

Department of Radiology and Imaging Sciences, Emory University Hospital, 59 Executive Park South, 4th Floor, Suite 4009, Atlanta, GA, 30329, USA. adam.singer@emoryhealthcare.org.Department of Radiology and Imaging Sciences, Emory University Hospital, 59 Executive Park South, 4th Floor, Suite 4009, Atlanta, GA, 30329, USA.Department of Radiology and Imaging Sciences, Emory University Hospital, 59 Executive Park South, 4th Floor, Suite 4009, Atlanta, GA, 30329, USA.Department of Orthopedic Surgery, Emory University Hospital, Atlanta, GA, USA.Department of Radiology and Imaging Sciences, Emory University Hospital, 59 Executive Park South, 4th Floor, Suite 4009, Atlanta, GA, 30329, USA.Department of Radiology and Imaging Sciences, Emory University Hospital, 59 Executive Park South, 4th Floor, Suite 4009, Atlanta, GA, 30329, USA.Department of Surgery, Division of Oncology, Emory University Hospital, Atlanta, GA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32601734

Citation

Singer, Adam Daniel, et al. "The Accuracy of a Novel Sonographic Scanning and Reporting Protocol to Survey for Soft Tissue Sarcoma Local Recurrence." Skeletal Radiology, 2020.
Singer AD, Wong P, Umpierrez M, et al. The accuracy of a novel sonographic scanning and reporting protocol to survey for soft tissue sarcoma local recurrence. Skeletal Radiol. 2020.
Singer, A. D., Wong, P., Umpierrez, M., Reimer, N., Gonzalez, F., Reiter, D., & Cardona, K. (2020). The accuracy of a novel sonographic scanning and reporting protocol to survey for soft tissue sarcoma local recurrence. Skeletal Radiology. https://doi.org/10.1007/s00256-020-03520-x
Singer AD, et al. The Accuracy of a Novel Sonographic Scanning and Reporting Protocol to Survey for Soft Tissue Sarcoma Local Recurrence. Skeletal Radiol. 2020 Jun 29; PubMed PMID: 32601734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The accuracy of a novel sonographic scanning and reporting protocol to survey for soft tissue sarcoma local recurrence. AU - Singer,Adam Daniel, AU - Wong,Phil, AU - Umpierrez,Monica, AU - Reimer,Nickolas, AU - Gonzalez,Felix, AU - Reiter,David, AU - Cardona,Kenneth, Y1 - 2020/06/29/ PY - 2020/05/12/received PY - 2020/06/15/accepted PY - 2020/06/13/revised PY - 2020/7/1/entrez KW - MRI KW - Sarcoma KW - Standardization KW - Surveillance KW - Ultrasound JF - Skeletal radiology JO - Skeletal Radiol. N2 - OBJECTIVE: This study aims to determine the accuracy of a novel ultrasonography (US) scanning and reporting protocol to detect recurrences. The secondary aim is to compare US and MRI accuracy and agreement. MATERIALS AND METHODS: In this IRB-approved prospective study, consecutive patients presenting for MRI surveillance after resection were enrolled and underwent same-day US. Blinded to clinical information and the MRI, the US scanner characterized lesions using a proposed novel lexicon. Outcome was defined either by histology or a subsequent MRI scan confirming the presence or absence of recurrence. Fisher's exact test and Kappa test were performed to assess of the significance and agreement between US, MRI, and outcome. RESULTS: A total of 68 US scans were performed on 55 patients. The overall accuracy to diagnose recurrence was the same for US and MRI (92.6%) while US was less sensitive (75.0% vs. 91.7%) but more specific (97.6% vs. 92.9%) than MRI. The two lesions missed by US but not MRI were an entirely intraosseous metastasis and a subcentimeter skin nodule. There was strong agreement between US and MRI with outcome (k = 0.787 and 0.801, respectively). CONCLUSIONS: These pilot data suggest the accuracy of this novel US local recurrence surveillance method is comparable to MRI. A multi-institutional prospective trial would increase power and determine reproducibility. SN - 1432-2161 UR - https://www.unboundmedicine.com/medline/citation/32601734/The_accuracy_of_a_novel_sonographic_scanning_and_reporting_protocol_to_survey_for_soft_tissue_sarcoma_local_recurrence L2 - https://doi.org/10.1007/s00256-020-03520-x DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.