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Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection.
Rev Med Virol. 2020 Sep; 30(5):e2122.RM

Abstract

Coronavirus (CoV) disease 2019 (COVID-19) is an ongoing pandemic caused by severe acute respiratory syndrome CoV 2 (SARS-CoV-2). The highly contagious SARS-CoV-2 belongs to the genus Betacoronavirus, and it is phylogenetically closely related to SARS-CoV, a human CoV that caused an outbreak back in 2002 to 2003. Both SARS-CoV-2 and SARS-CoV enter human cells via the interactions between viral crown-like spike protein and human angiotensin-converting enzyme 2 (ACE2) receptor. Here, we aim to review the involvement of ACE2 in human CoV infections by discussing the roles of ACE2 in CoV evolution, cross-species transmissibility, and COVID-19 susceptibility. We also provide our perspectives on COVID-19 treatment and prevention.

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Authors+Show Affiliations

Tan HW
Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, People's Republic of China.
Xu YM
Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, People's Republic of China.
Lau ATY
Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, People's Republic of China.

MeSH

Angiotensin-Converting Enzyme 2AnimalsBetacoronavirusBiological EvolutionCOVID-19ChiropteraCoronavirus InfectionsEutheriaGene Expression RegulationHumansPandemicsPeptidyl-Dipeptidase APhylogenyPneumonia, ViralProtein BindingReceptors, VirusSevere acute respiratory syndrome-related coronavirusSARS-CoV-2Severe Acute Respiratory SyndromeSpike Glycoprotein, CoronavirusVirus Internalization

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32602627

Citation

Tan, Heng Wee, et al. "Angiotensin-converting Enzyme 2: the Old Door for New Severe Acute Respiratory Syndrome Coronavirus 2 Infection." Reviews in Medical Virology, vol. 30, no. 5, 2020, pp. e2122.
Tan HW, Xu YM, Lau ATY. Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection. Rev Med Virol. 2020;30(5):e2122.
Tan, H. W., Xu, Y. M., & Lau, A. T. Y. (2020). Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection. Reviews in Medical Virology, 30(5), e2122. https://doi.org/10.1002/rmv.2122
Tan HW, Xu YM, Lau ATY. Angiotensin-converting Enzyme 2: the Old Door for New Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Rev Med Virol. 2020;30(5):e2122. PubMed PMID: 32602627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection. AU - Tan,Heng Wee, AU - Xu,Yan-Ming, AU - Lau,Andy T Y, Y1 - 2020/06/30/ PY - 2020/3/20/received PY - 2020/4/30/revised PY - 2020/5/4/accepted PY - 2020/7/1/pubmed PY - 2020/10/2/medline PY - 2020/7/1/entrez KW - ACE2 KW - COVID-19 KW - SARS-CoV-2 SP - e2122 EP - e2122 JF - Reviews in medical virology JO - Rev Med Virol VL - 30 IS - 5 N2 - Coronavirus (CoV) disease 2019 (COVID-19) is an ongoing pandemic caused by severe acute respiratory syndrome CoV 2 (SARS-CoV-2). The highly contagious SARS-CoV-2 belongs to the genus Betacoronavirus, and it is phylogenetically closely related to SARS-CoV, a human CoV that caused an outbreak back in 2002 to 2003. Both SARS-CoV-2 and SARS-CoV enter human cells via the interactions between viral crown-like spike protein and human angiotensin-converting enzyme 2 (ACE2) receptor. Here, we aim to review the involvement of ACE2 in human CoV infections by discussing the roles of ACE2 in CoV evolution, cross-species transmissibility, and COVID-19 susceptibility. We also provide our perspectives on COVID-19 treatment and prevention. SN - 1099-1654 UR - https://www.unboundmedicine.com/medline/citation/32602627/Angiotensin_converting_enzyme_2:_The_old_door_for_new_severe_acute_respiratory_syndrome_coronavirus_2_infection_ DB - PRIME DP - Unbound Medicine ER -