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Comparison of sTREM-1 and associated periodontal and bacterial factors before/after periodontal therapy, and impact of psychosocial factors.
J Clin Periodontol. 2020 Jun 30 [Online ahead of print]JC

Abstract

AIM

The immune receptor triggering receptor expressed on myeloid cell-1 (TREM-1) is responsible for an amplification of the immuno-inflammatory response in inflammatory diseases. Its role in the aetiopathogenesis of periodontitis is underexplored. The aim of this case-control and before-after study was to determine the evolution of soluble form of TREM-1 (sTREM-1) concentrations after scaling and root planing (SRP), and its prognostic value and evaluate associated microbial, periodontal and psychosocial factors.

METHODS

Gingival crevicular fluid was collected in two pathological sites (periodontal pocket depth (PPD) ≥ 5 mm) and one healthy site (PPD ≤ 3 mm) from thirty periodontitis patients (before/after SRP), and in one healthy site from thirty controls (patients without periodontal disease). Each patient filled-in stress/anxiety self-assessment questionnaires and provided a saliva sample. Diseased patients were followed for a total of 13-15 weeks in initial periodontal treatment. sTREM-1 and salivary cortisol levels were determined by ELISA and periodontopathogens by PCR.

RESULTS

Before SRP, higher crevicular sTREM-1 levels were positively associated with some increased clinical parameters (Plaque Index, tooth mobility, bleeding on probing, p < .05) and inversely with Aggregatibacter actinomycetemcomitans abundance (p = .03). No correlation with psychological factors nor cortisol was found with salivary sTREM-1 concentrations. After SRP, crevicular sTREM-1 levels decreased (p < .001) and were not linked to a PPD decrease but remained higher in pathological than in healthy sites (p < .001). Higher concentrations were also found out in unimproved sites (no change or increase in PPD) compared to improved ones (p = .02). Higher sTREM-1 levels were associated with Porphyromonas gingivalis, Treponema denticola and Campylobacter rectus in pathological sites after SRP (p < .05).

CONCLUSION

Crevicular sTREM-1 level decreased after SRP but did not appear to be a site outcome predictive factor of periodontal healing and remained an inflammatory parameter.

Authors+Show Affiliations

Department of Periodontology, School of Dentistry, Lille University Hospital, Lille, France. Laboratory of Stress Immunity Pathogens, EA 7300, Faculty of Medicine, University of Lorraine, Vandoeuvre-lès-Nancy, France.Laboratory of Stress Immunity Pathogens, EA 7300, Faculty of Medicine, University of Lorraine, Vandoeuvre-lès-Nancy, France.Clinical Research Support Facility PARC, UMDS, Nancy University Hospital, Vandoeuvre-lès-Nancy, France.INOTREM, Vandœuvre-lès-Nancy, France.Laboratory of Stress Immunity Pathogens, EA 7300, Faculty of Medicine, University of Lorraine, Vandoeuvre-lès-Nancy, France. Laboratory of Bacteriology, Nancy University Hospital, University of Lorraine, Vandoeuvre-Lès-Nancy, France.Clinical Research Support Facility PARC, UMDS, Nancy University Hospital, Vandoeuvre-lès-Nancy, France.Medical Intensive Care Unit, Hôpital Central, Nancy University Hospital, Nancy, France. Department de Periodontology, Nancy University Hospital, University of Lorraine, Nancy, France.Laboratory of Stress Immunity Pathogens, EA 7300, Faculty of Medicine, University of Lorraine, Vandoeuvre-lès-Nancy, France. Department of Periodontology, University Hospital and University of Lorraine, Nancy, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32602969

Citation

Dubar, Marie, et al. "Comparison of sTREM-1 and Associated Periodontal and Bacterial Factors Before/after Periodontal Therapy, and Impact of Psychosocial Factors." Journal of Clinical Periodontology, 2020.
Dubar M, Frippiat JP, Remen T, et al. Comparison of sTREM-1 and associated periodontal and bacterial factors before/after periodontal therapy, and impact of psychosocial factors. J Clin Periodontol. 2020.
Dubar, M., Frippiat, J. P., Remen, T., Boufenzer, A., Alauzet, C., Baumann, C., Gibot, S., & Bisson, C. (2020). Comparison of sTREM-1 and associated periodontal and bacterial factors before/after periodontal therapy, and impact of psychosocial factors. Journal of Clinical Periodontology. https://doi.org/10.1111/jcpe.13339
Dubar M, et al. Comparison of sTREM-1 and Associated Periodontal and Bacterial Factors Before/after Periodontal Therapy, and Impact of Psychosocial Factors. J Clin Periodontol. 2020 Jun 30; PubMed PMID: 32602969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of sTREM-1 and associated periodontal and bacterial factors before/after periodontal therapy, and impact of psychosocial factors. AU - Dubar,Marie, AU - Frippiat,Jean-Pol, AU - Remen,Thomas, AU - Boufenzer,Amir, AU - Alauzet,Corentine, AU - Baumann,Cedric, AU - Gibot,Sebastien, AU - Bisson,Catherine, Y1 - 2020/06/30/ PY - 2019/10/05/received PY - 2020/05/11/revised PY - 2020/06/18/accepted PY - 2020/7/1/pubmed PY - 2020/7/1/medline PY - 2020/7/1/entrez KW - cortisol KW - periodontal bacteria KW - periodontal therapy KW - periodontitis KW - psychosocial parameters KW - sTREM-1 JF - Journal of clinical periodontology JO - J. Clin. Periodontol. N2 - AIM: The immune receptor triggering receptor expressed on myeloid cell-1 (TREM-1) is responsible for an amplification of the immuno-inflammatory response in inflammatory diseases. Its role in the aetiopathogenesis of periodontitis is underexplored. The aim of this case-control and before-after study was to determine the evolution of soluble form of TREM-1 (sTREM-1) concentrations after scaling and root planing (SRP), and its prognostic value and evaluate associated microbial, periodontal and psychosocial factors. METHODS: Gingival crevicular fluid was collected in two pathological sites (periodontal pocket depth (PPD) ≥ 5 mm) and one healthy site (PPD ≤ 3 mm) from thirty periodontitis patients (before/after SRP), and in one healthy site from thirty controls (patients without periodontal disease). Each patient filled-in stress/anxiety self-assessment questionnaires and provided a saliva sample. Diseased patients were followed for a total of 13-15 weeks in initial periodontal treatment. sTREM-1 and salivary cortisol levels were determined by ELISA and periodontopathogens by PCR. RESULTS: Before SRP, higher crevicular sTREM-1 levels were positively associated with some increased clinical parameters (Plaque Index, tooth mobility, bleeding on probing, p < .05) and inversely with Aggregatibacter actinomycetemcomitans abundance (p = .03). No correlation with psychological factors nor cortisol was found with salivary sTREM-1 concentrations. After SRP, crevicular sTREM-1 levels decreased (p < .001) and were not linked to a PPD decrease but remained higher in pathological than in healthy sites (p < .001). Higher concentrations were also found out in unimproved sites (no change or increase in PPD) compared to improved ones (p = .02). Higher sTREM-1 levels were associated with Porphyromonas gingivalis, Treponema denticola and Campylobacter rectus in pathological sites after SRP (p < .05). CONCLUSION: Crevicular sTREM-1 level decreased after SRP but did not appear to be a site outcome predictive factor of periodontal healing and remained an inflammatory parameter. SN - 1600-051X UR - https://www.unboundmedicine.com/medline/citation/32602969/Comparison_of_sTREM-1_and_associated_periodontal_and_bacterial_factors_before/after_periodontal_therapy,_and_impact_of_psychosocial_factors L2 - https://doi.org/10.1111/jcpe.13339 DB - PRIME DP - Unbound Medicine ER -
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