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A Multicenter Evaluation of a Nongel Mechanical Separator Plasma Blood Collection Tube for Testing of Selected Therapeutic Drugs.
J Appl Lab Med. 2020 Jul 01; 5(4):671-685.JA

Abstract

BACKGROUND

Some therapeutic drugs are unstable during sample storage in gel tubes. BD Vacutainer® Barricor™ Plasma Blood Collection Tube with nongel separator was compared with plasma gel tubes, BD Vacutainer PST™, PST II, and BD Vacutainer Serum Tube for acetaminophen, salicylate, digoxin, carbamazepine, phenytoin, valproic acid, and vancomycin during sample storage for up to 7 days.

METHODS

Seven hospital sites enrolled 705 participants who were taking at least one selected drug. The study tubes were collected and tested at initial time (0 h), after 48 h of storage at room temperature and on day 7 (after additional 5 days of refrigerated storage). The performance of BD Barricor tube was evaluated for each drug by comparing BD Barricor samples with samples from the other tubes at 0 h from the same participant; stability was evaluated by comparing test results from the same tube at 0 h, 48 h, and 7 days.

RESULTS

At 0 h, BD Barricor showed clinically equivalent results for selected therapeutic drugs compared with the other tubes, except phenytoin in BD PST. Phenytoin samples ≥20 µg/mL in BD PST had 10-12% lower values than samples in BD Barricor. During sample storage, all selected drugs remained stable for 7 days in BD Barricor and in serum aliquots. In BD PST, all drugs remained stable except phenytoin and carbamazepine and in BD PST II except for phenytoin.

CONCLUSION

The BD Barricor Tube is effective for the collection and storage of plasma blood samples for therapeutic drug monitoring without sample aliquoting.

Authors+Show Affiliations

BD, Franklin Lakes, NJ.BD, Franklin Lakes, NJ.School of Medicine, University of Maryland, MD, USA.University of California, San Francisco, San Francisco, CA.John T. Mather Memorial Hospital, Port Jefferson, NY.University Hospital, Hradec Krάlόve, Czech Republic.University Hospital Motol, Prague, Czech Republic.General University Hospital, Prague, Czech Republic.School of Medicine, University of Maryland, MD, USA.BD, Franklin Lakes, NJ.BD, Franklin Lakes, NJ.BD, Franklin Lakes, NJ.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32603441

Citation

Morosyuk, Svetlana, et al. "A Multicenter Evaluation of a Nongel Mechanical Separator Plasma Blood Collection Tube for Testing of Selected Therapeutic Drugs." The Journal of Applied Laboratory Medicine, vol. 5, no. 4, 2020, pp. 671-685.
Morosyuk S, Berube J, Christenson R, et al. A Multicenter Evaluation of a Nongel Mechanical Separator Plasma Blood Collection Tube for Testing of Selected Therapeutic Drugs. J Appl Lab Med. 2020;5(4):671-685.
Morosyuk, S., Berube, J., Christenson, R., Wu, A. H. B., Uettwiller-Geiger, D., Palicka, V., Prusa, R., Zima, T., Shaw, K., Plokhoy, E., Ahuja, A. J., & Stankovic, A. K. (2020). A Multicenter Evaluation of a Nongel Mechanical Separator Plasma Blood Collection Tube for Testing of Selected Therapeutic Drugs. The Journal of Applied Laboratory Medicine, 5(4), 671-685. https://doi.org/10.1093/jalm/jfaa033
Morosyuk S, et al. A Multicenter Evaluation of a Nongel Mechanical Separator Plasma Blood Collection Tube for Testing of Selected Therapeutic Drugs. J Appl Lab Med. 2020 Jul 1;5(4):671-685. PubMed PMID: 32603441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Multicenter Evaluation of a Nongel Mechanical Separator Plasma Blood Collection Tube for Testing of Selected Therapeutic Drugs. AU - Morosyuk,Svetlana, AU - Berube,Julie, AU - Christenson,Robert, AU - Wu,Alan H B, AU - Uettwiller-Geiger,Denise, AU - Palicka,Vladimir, AU - Prusa,Richard, AU - Zima,Tomas, AU - Shaw,Kristin, AU - Plokhoy,Elizabeth, AU - Ahuja,Aparna J, AU - Stankovic,Ana K, PY - 2019/08/06/received PY - 2019/12/16/accepted PY - 2020/7/1/entrez PY - 2020/7/1/pubmed PY - 2020/7/1/medline KW - Barricor KW - TDM KW - gel adsorption KW - therapeutic drug monitoring KW - therapeutic drug stability SP - 671 EP - 685 JF - The journal of applied laboratory medicine JO - J Appl Lab Med VL - 5 IS - 4 N2 - BACKGROUND: Some therapeutic drugs are unstable during sample storage in gel tubes. BD Vacutainer® Barricor™ Plasma Blood Collection Tube with nongel separator was compared with plasma gel tubes, BD Vacutainer PST™, PST II, and BD Vacutainer Serum Tube for acetaminophen, salicylate, digoxin, carbamazepine, phenytoin, valproic acid, and vancomycin during sample storage for up to 7 days. METHODS: Seven hospital sites enrolled 705 participants who were taking at least one selected drug. The study tubes were collected and tested at initial time (0 h), after 48 h of storage at room temperature and on day 7 (after additional 5 days of refrigerated storage). The performance of BD Barricor tube was evaluated for each drug by comparing BD Barricor samples with samples from the other tubes at 0 h from the same participant; stability was evaluated by comparing test results from the same tube at 0 h, 48 h, and 7 days. RESULTS: At 0 h, BD Barricor showed clinically equivalent results for selected therapeutic drugs compared with the other tubes, except phenytoin in BD PST. Phenytoin samples ≥20 µg/mL in BD PST had 10-12% lower values than samples in BD Barricor. During sample storage, all selected drugs remained stable for 7 days in BD Barricor and in serum aliquots. In BD PST, all drugs remained stable except phenytoin and carbamazepine and in BD PST II except for phenytoin. CONCLUSION: The BD Barricor Tube is effective for the collection and storage of plasma blood samples for therapeutic drug monitoring without sample aliquoting. SN - 2576-9456 UR - https://www.unboundmedicine.com/medline/citation/32603441/A_Multicenter_Evaluation_of_a_Nongel_Mechanical_Separator_Plasma_Blood_Collection_Tube_for_Testing_of_Selected_Therapeutic_Drugs L2 - http://jalm.aaccjnls.org/cgi/pmidlookup?view=long&pmid=32603441 DB - PRIME DP - Unbound Medicine ER -
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