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Radiological characteristics of neuromyelitis optica spectrum disorder in Kuwait.
Clin Neurol Neurosurg. 2020 Jun 24; 196:106047.CN

Abstract

BACKGROUND

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disorder of the central nervous system that predominantly targets optic nerves and spinal cord. Studies of NMOSD are scarce in the Middle East.

OBJECTIVE

To evaluate the MRI characteristics of NMOSD patients in Kuwait.

PATIENT AND METHODS

This is an observational, retrospective study on NMOSD patients who attended the MS clinic. Patients who fulfilled the 2015 diagnostic criteria of NMOSD were included. Patients` clinical, radiological and serological data were extracted from the medical records. The radiological variables were compared according to gender and AQP4 serostatus.

RESULTS

Forty-two patients fulfilling the NMOSD diagnostic criteria. The mean age and mean age of onset were 32.6 ± 11.4 and 28.9 ± 9.8 years respectively. Females represented 83.3 % of the cohort with female-to-male ratio of 5:1. Thirty-one patients (73.8 %) tested positive for AQP4 antibody. Nineteen patients (45.2 %) had bilateral optic nerve involvement, while chiasmal involvement was seen in 8 (19.0 %) patients. Spinal cord was involved in 36 (85.7 %) patients; of whom 27 (64.3 %) had LETM. The most common spinal segment involved was the cervical (72.2 %) followed by the dorsal (25.0 %) regions. The brain was involved in 39 (92.8 %) patients and the periventricular region around fourth and lateral ventricles was the most commonly involved site (n = 35; 83.3 %), along with periaqueductal (n = 25; 61.9 %) and corpus callosal (n = 24; 57.1 %) regions. Isolated area postrema involvement was observed in 9 (21.4 %) patients.

CONCLUSION

This is the first study describing the radiological characteristics of NMOSD in Kuwait. Although our data is comparable with the previous international studies, a higher percentage of bilateral optic nerve, brain, and callosal involvement was observed. Further multicenter studies with a larger cohort are needed to confirm our results.

Authors+Show Affiliations

Department of Neurology, Ibn Sina Hospital, Kuwait. Electronic address: dr.ismail.ibrahim2012@gmail.com.Department of Neurology, Ibn Sina Hospital, Kuwait; Department of Neurology and Psychiatry, Minia University, Egypt. Electronic address: samerelshayb@hotmail.com.Department of Neurology, Ibn Sina Hospital, Kuwait; Health Sciences Centre, Kuwait University, Department of Medicine, Kuwait. Electronic address: jasemkumsa@hotmail.com.Department of Radiology, Ibn Sina Hospital, Kuwait. Electronic address: afandena@gmail.com.Division of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwait. Electronic address: alroughani@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32604036

Citation

Ismail, Ismail Ibrahim, et al. "Radiological Characteristics of Neuromyelitis Optica Spectrum Disorder in Kuwait." Clinical Neurology and Neurosurgery, vol. 196, 2020, p. 106047.
Ismail II, Ahmed SF, Al-Hashel JY, et al. Radiological characteristics of neuromyelitis optica spectrum disorder in Kuwait. Clin Neurol Neurosurg. 2020;196:106047.
Ismail, I. I., Ahmed, S. F., Al-Hashel, J. Y., Abdelnabi, E. A., & Alroughani, R. (2020). Radiological characteristics of neuromyelitis optica spectrum disorder in Kuwait. Clinical Neurology and Neurosurgery, 196, 106047. https://doi.org/10.1016/j.clineuro.2020.106047
Ismail II, et al. Radiological Characteristics of Neuromyelitis Optica Spectrum Disorder in Kuwait. Clin Neurol Neurosurg. 2020 Jun 24;196:106047. PubMed PMID: 32604036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radiological characteristics of neuromyelitis optica spectrum disorder in Kuwait. AU - Ismail,Ismail Ibrahim, AU - Ahmed,Samar Farouk, AU - Al-Hashel,Jasem Y, AU - Abdelnabi,Ehab A, AU - Alroughani,Raed, Y1 - 2020/06/24/ PY - 2020/01/24/received PY - 2020/06/22/revised PY - 2020/06/23/accepted PY - 2020/7/1/pubmed PY - 2020/7/1/medline PY - 2020/7/1/entrez KW - Kuwait KW - Magnetic resonance imaging KW - Neuromyelitis optica KW - Neuromyelitis optica spectrum disorder KW - Optic neuritis KW - Transverse myelitis SP - 106047 EP - 106047 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 196 N2 - BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disorder of the central nervous system that predominantly targets optic nerves and spinal cord. Studies of NMOSD are scarce in the Middle East. OBJECTIVE: To evaluate the MRI characteristics of NMOSD patients in Kuwait. PATIENT AND METHODS: This is an observational, retrospective study on NMOSD patients who attended the MS clinic. Patients who fulfilled the 2015 diagnostic criteria of NMOSD were included. Patients` clinical, radiological and serological data were extracted from the medical records. The radiological variables were compared according to gender and AQP4 serostatus. RESULTS: Forty-two patients fulfilling the NMOSD diagnostic criteria. The mean age and mean age of onset were 32.6 ± 11.4 and 28.9 ± 9.8 years respectively. Females represented 83.3 % of the cohort with female-to-male ratio of 5:1. Thirty-one patients (73.8 %) tested positive for AQP4 antibody. Nineteen patients (45.2 %) had bilateral optic nerve involvement, while chiasmal involvement was seen in 8 (19.0 %) patients. Spinal cord was involved in 36 (85.7 %) patients; of whom 27 (64.3 %) had LETM. The most common spinal segment involved was the cervical (72.2 %) followed by the dorsal (25.0 %) regions. The brain was involved in 39 (92.8 %) patients and the periventricular region around fourth and lateral ventricles was the most commonly involved site (n = 35; 83.3 %), along with periaqueductal (n = 25; 61.9 %) and corpus callosal (n = 24; 57.1 %) regions. Isolated area postrema involvement was observed in 9 (21.4 %) patients. CONCLUSION: This is the first study describing the radiological characteristics of NMOSD in Kuwait. Although our data is comparable with the previous international studies, a higher percentage of bilateral optic nerve, brain, and callosal involvement was observed. Further multicenter studies with a larger cohort are needed to confirm our results. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/32604036/Radiological_characteristics_of_neuromyelitis_optica_spectrum_disorder_in_Kuwait L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(20)30390-5 DB - PRIME DP - Unbound Medicine ER -
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