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A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd: YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians.
Dermatol Surg. 2020 Jun 25 [Online ahead of print]DS

Abstract

BACKGROUND

Whether picosecond lasers outperform Q-switched lasers in treating pigmented lesions has not been clearly evaluated.

OBJECTIVE

To compare the efficacy and safety of picosecond and Q-switched lasers in treating epidermal and dermal pigmented lesions in Asians.

METHODS

Eight subjects with lentigines and 6 subjects with acquired bilateral nevus of Ota-like macules were enrolled. Subjects was randomly treated with a picosecond laser on one side of the face and a Q-switched laser on the other side. Subjective assessments on pigment clearance, and adverse effect were obtained at Weeks 0, 4, 12, and 24 after the final treatment.

RESULTS

Clinical improvement differed between the 2 laser systems at Week 4 (p = .034), Week 12 (p = .039), and Week 24 (p = .027), with 85.7% of picosecond and 57.2% of Q-switched laser sites showing >50% improvement at 6 months. There was no significant difference in the incidence of side effect and healing time, but picosecond laser was significantly associated with a lower treatment discomfort (p = .05).

CONCLUSION

The picosecond laser seems to be more effective and better tolerated than Q-switched laser for the treatment of pigmented lesions in Asians.

Authors+Show Affiliations

*All authors are affiliated with the Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableAll authors are affiliated with the Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32604235

Citation

Ungaksornpairote, Chanida, et al. "A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd: YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians." Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.], 2020.
Ungaksornpairote C, Manuskiatti W, Junsuwan N, et al. A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd: YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians. Dermatol Surg. 2020.
Ungaksornpairote, C., Manuskiatti, W., Junsuwan, N., & Wanitphakdeedecha, R. (2020). A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd: YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians. Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]. https://doi.org/10.1097/DSS.0000000000002486
Ungaksornpairote C, et al. A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd: YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians. Dermatol Surg. 2020 Jun 25; PubMed PMID: 32604235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd: YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians. AU - Ungaksornpairote,Chanida, AU - Manuskiatti,Woraphong, AU - Junsuwan,Natchaya, AU - Wanitphakdeedecha,Rungsima, Y1 - 2020/06/25/ PY - 2020/7/1/entrez PY - 2020/7/1/pubmed PY - 2020/7/1/medline JF - Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] JO - Dermatol Surg N2 - BACKGROUND: Whether picosecond lasers outperform Q-switched lasers in treating pigmented lesions has not been clearly evaluated. OBJECTIVE: To compare the efficacy and safety of picosecond and Q-switched lasers in treating epidermal and dermal pigmented lesions in Asians. METHODS: Eight subjects with lentigines and 6 subjects with acquired bilateral nevus of Ota-like macules were enrolled. Subjects was randomly treated with a picosecond laser on one side of the face and a Q-switched laser on the other side. Subjective assessments on pigment clearance, and adverse effect were obtained at Weeks 0, 4, 12, and 24 after the final treatment. RESULTS: Clinical improvement differed between the 2 laser systems at Week 4 (p = .034), Week 12 (p = .039), and Week 24 (p = .027), with 85.7% of picosecond and 57.2% of Q-switched laser sites showing >50% improvement at 6 months. There was no significant difference in the incidence of side effect and healing time, but picosecond laser was significantly associated with a lower treatment discomfort (p = .05). CONCLUSION: The picosecond laser seems to be more effective and better tolerated than Q-switched laser for the treatment of pigmented lesions in Asians. SN - 1524-4725 UR - https://www.unboundmedicine.com/medline/citation/32604235/A_Prospective,_Split-Face,_Randomized_Study_Comparing_Picosecond_to_Q-Switched_Nd:_YAG_Laser_for_Treatment_of_Epidermal_and_Dermal_Pigmented_Lesions_in_Asians L2 - https://doi.org/10.1097/DSS.0000000000002486 DB - PRIME DP - Unbound Medicine ER -
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