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Fatal accident involving a welder employed by a shipping container company, associated with the use of tramadol and antidepressant agents.
Int Marit Health. 2020; 71(2):109-113.IM

Abstract

The widespread use of opioids for the treatment of moderate or severe acute and chronic pain has become a public health problem due to the physical and psychological dependence and tolerance they produce. The increasingly higher doses that patients require may reach toxic levels or lead to accidents, including fatalities. We present the case of a welder who, while working for a shipping container company, fell from height without a safety harness and subsequently died as a result of a traumatic brain injury. Post-mortem examination revealed a cardiac blood tramadol concentration of 2.83 mg/L, which is 3-4 times higher than the maximum therapeutic dose. The combined use of synthetic opioids and antidepressants may heighten the adverse neurological and psychiatric effects. A review of the literature, identified studies, including previous reports of fatalities, supported our causal hypothesis of a serotonin syndrome. This syndrome can lead to a loss of cognitive and sensory capacity, interfere with decision-making ability, and produce mental confusion and dizziness, among other symptoms. In order to prevent harm to themselves and others, all persons who are currently taking these kinds of drugs should avoid dangerous tasks at work and must be advised by a physician regarding the type of activities that are safe for them to perform.

Authors+Show Affiliations

Unit of Occupational Medicine and Toxicology, School of Medicine and Health Sciences of Barcelona, University of Barcelona, C/Casanova, 146, 08036 Barcelona, Spain. 17039psg@comb.cat.Unit of Occupational Medicine and Toxicology, School of Medicine and Health Sciences of Barcelona, University of Barcelona, C/Casanova, 146, 08036 Barcelona, Spain.Maritime Health Unit, ISM Tarragona, Spain.Unit of Occupational Medicine and Toxicology, School of Medicine and Health Sciences of Barcelona, University of Barcelona, C/Casanova, 146, 08036 Barcelona, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32604453

Citation

Sanz-Gallen, Pere, et al. "Fatal Accident Involving a Welder Employed By a Shipping Container Company, Associated With the Use of Tramadol and Antidepressant Agents." International Maritime Health, vol. 71, no. 2, 2020, pp. 109-113.
Sanz-Gallen P, Amigó de Bonet N, Canals ML, et al. Fatal accident involving a welder employed by a shipping container company, associated with the use of tramadol and antidepressant agents. Int Marit Health. 2020;71(2):109-113.
Sanz-Gallen, P., Amigó de Bonet, N., Canals, M. L., & Martí-Amengual, G. (2020). Fatal accident involving a welder employed by a shipping container company, associated with the use of tramadol and antidepressant agents. International Maritime Health, 71(2), 109-113. https://doi.org/10.5603/IMH.2020.0020
Sanz-Gallen P, et al. Fatal Accident Involving a Welder Employed By a Shipping Container Company, Associated With the Use of Tramadol and Antidepressant Agents. Int Marit Health. 2020;71(2):109-113. PubMed PMID: 32604453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatal accident involving a welder employed by a shipping container company, associated with the use of tramadol and antidepressant agents. AU - Sanz-Gallen,Pere, AU - Amigó de Bonet,Narciso, AU - Canals,María Luisa, AU - Martí-Amengual,Gabriel, PY - 2020/05/13/received PY - 2020/06/12/accepted PY - 2020/06/11/revised PY - 2020/7/1/entrez PY - 2020/7/1/pubmed PY - 2020/7/1/medline KW - adverse reactions KW - antidepressant agents KW - drug-related side effects KW - fatal outcomes KW - occupational accidents KW - opioid abuse KW - poisoning SP - 109 EP - 113 JF - International maritime health JO - Int Marit Health VL - 71 IS - 2 N2 - The widespread use of opioids for the treatment of moderate or severe acute and chronic pain has become a public health problem due to the physical and psychological dependence and tolerance they produce. The increasingly higher doses that patients require may reach toxic levels or lead to accidents, including fatalities. We present the case of a welder who, while working for a shipping container company, fell from height without a safety harness and subsequently died as a result of a traumatic brain injury. Post-mortem examination revealed a cardiac blood tramadol concentration of 2.83 mg/L, which is 3-4 times higher than the maximum therapeutic dose. The combined use of synthetic opioids and antidepressants may heighten the adverse neurological and psychiatric effects. A review of the literature, identified studies, including previous reports of fatalities, supported our causal hypothesis of a serotonin syndrome. This syndrome can lead to a loss of cognitive and sensory capacity, interfere with decision-making ability, and produce mental confusion and dizziness, among other symptoms. In order to prevent harm to themselves and others, all persons who are currently taking these kinds of drugs should avoid dangerous tasks at work and must be advised by a physician regarding the type of activities that are safe for them to perform. SN - 2081-3252 UR - https://www.unboundmedicine.com/medline/citation/32604453/Fatal_accident_involving_a_welder_employed_by_a_shipping_container_company,_associated_with_the_use_of_tramadol_and_antidepressant_agents L2 - https://journals.viamedica.pl/international_maritime_health/article/view/68965 DB - PRIME DP - Unbound Medicine ER -
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