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Betacoronavirus Genomes: How Genomic Information has been Used to Deal with Past Outbreaks and the COVID-19 Pandemic.
Int J Mol Sci. 2020 Jun 26; 21(12)IJ

Abstract

In the 21st century, three highly pathogenic betacoronaviruses have emerged, with an alarming rate of human morbidity and case fatality. Genomic information has been widely used to understand the pathogenesis, animal origin and mode of transmission of coronaviruses in the aftermath of the 2002-2003 severe acute respiratory syndrome (SARS) and 2012 Middle East respiratory syndrome (MERS) outbreaks. Furthermore, genome sequencing and bioinformatic analysis have had an unprecedented relevance in the battle against the 2019-2020 coronavirus disease 2019 (COVID-19) pandemic, the newest and most devastating outbreak caused by a coronavirus in the history of mankind. Here, we review how genomic information has been used to tackle outbreaks caused by emerging, highly pathogenic, betacoronavirus strains, emphasizing on SARS-CoV, MERS-CoV and SARS-CoV-2. We focus on shared genomic features of the betacoronaviruses and the application of genomic information to phylogenetic analysis, molecular epidemiology and the design of diagnostic systems, potential drugs and vaccine candidates.

Authors+Show Affiliations

Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama City 0801, Panama.Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama City 0801, Panama.Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama City 0801, Panama.College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama City 0801, Panama.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32604724

Citation

Llanes, Alejandro, et al. "Betacoronavirus Genomes: How Genomic Information Has Been Used to Deal With Past Outbreaks and the COVID-19 Pandemic." International Journal of Molecular Sciences, vol. 21, no. 12, 2020.
Llanes A, Restrepo CM, Caballero Z, et al. Betacoronavirus Genomes: How Genomic Information has been Used to Deal with Past Outbreaks and the COVID-19 Pandemic. Int J Mol Sci. 2020;21(12).
Llanes, A., Restrepo, C. M., Caballero, Z., Rajeev, S., Kennedy, M. A., & Lleonart, R. (2020). Betacoronavirus Genomes: How Genomic Information has been Used to Deal with Past Outbreaks and the COVID-19 Pandemic. International Journal of Molecular Sciences, 21(12). https://doi.org/10.3390/ijms21124546
Llanes A, et al. Betacoronavirus Genomes: How Genomic Information Has Been Used to Deal With Past Outbreaks and the COVID-19 Pandemic. Int J Mol Sci. 2020 Jun 26;21(12) PubMed PMID: 32604724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Betacoronavirus Genomes: How Genomic Information has been Used to Deal with Past Outbreaks and the COVID-19 Pandemic. AU - Llanes,Alejandro, AU - Restrepo,Carlos M, AU - Caballero,Zuleima, AU - Rajeev,Sreekumari, AU - Kennedy,Melissa A, AU - Lleonart,Ricardo, Y1 - 2020/06/26/ PY - 2020/05/29/received PY - 2020/06/22/revised PY - 2020/06/23/accepted PY - 2020/7/2/entrez PY - 2020/7/2/pubmed PY - 2020/7/8/medline KW - COVID-19 KW - MERS-CoV KW - SARS-CoV KW - SARS-CoV-2 KW - betacoronaviruses KW - genomics JF - International journal of molecular sciences JO - Int J Mol Sci VL - 21 IS - 12 N2 - In the 21st century, three highly pathogenic betacoronaviruses have emerged, with an alarming rate of human morbidity and case fatality. Genomic information has been widely used to understand the pathogenesis, animal origin and mode of transmission of coronaviruses in the aftermath of the 2002-2003 severe acute respiratory syndrome (SARS) and 2012 Middle East respiratory syndrome (MERS) outbreaks. Furthermore, genome sequencing and bioinformatic analysis have had an unprecedented relevance in the battle against the 2019-2020 coronavirus disease 2019 (COVID-19) pandemic, the newest and most devastating outbreak caused by a coronavirus in the history of mankind. Here, we review how genomic information has been used to tackle outbreaks caused by emerging, highly pathogenic, betacoronavirus strains, emphasizing on SARS-CoV, MERS-CoV and SARS-CoV-2. We focus on shared genomic features of the betacoronaviruses and the application of genomic information to phylogenetic analysis, molecular epidemiology and the design of diagnostic systems, potential drugs and vaccine candidates. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/32604724/Betacoronavirus_Genomes:_How_Genomic_Information_has_been_Used_to_Deal_with_Past_Outbreaks_and_the_COVID_19_Pandemic_ L2 - https://www.mdpi.com/resolver?pii=ijms21124546 DB - PRIME DP - Unbound Medicine ER -