Tags

Type your tag names separated by a space and hit enter

Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation.
Biomolecules. 2020 Jun 26; 10(6)B

Abstract

During embryonic development and adulthood, Reelin exerts several important functions in the brain including the regulation of neuronal migration, dendritic growth and branching, dendritic spine formation, synaptogenesis and synaptic plasticity. As a consequence, the Reelin signaling pathway has been associated with several human brain disorders such as lissencephaly, autism, schizophrenia, bipolar disorder, depression, mental retardation, Alzheimer's disease and epilepsy. Several elements of the signaling pathway are known. Core components, such as the Reelin receptors very low-density lipoprotein receptor (VLDLR) and Apolipoprotein E receptor 2 (ApoER2), Src family kinases Src and Fyn, and the intracellular adaptor Disabled-1 (Dab1), are common to most but not all Reelin functions. Other downstream effectors are, on the other hand, more specific to defined tasks. Reelin is a large extracellular protein, and some aspects of the signal are regulated by its processing into smaller fragments. Rather than being inhibitory, the processing at two major sites seems to be fulfilling important physiological functions. In this review, I describe the various cellular events regulated by Reelin and attempt to explain the current knowledge on the mechanisms of action. After discussing the shared and distinct elements of the Reelin signaling pathway involved in neuronal migration, dendritic growth, spine development and synaptic plasticity, I briefly outline the data revealing the importance of Reelin in human brain disorders.

Authors+Show Affiliations

Laboratory of Mammalian Development & Cell Biology, Institute of Neuroscience, Université Catholique de Louvain, 1200 Brussels, Belgium.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32604886

Citation

Jossin, Yves. "Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation." Biomolecules, vol. 10, no. 6, 2020.
Jossin Y. Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation. Biomolecules. 2020;10(6).
Jossin, Y. (2020). Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation. Biomolecules, 10(6). https://doi.org/10.3390/biom10060964
Jossin Y. Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation. Biomolecules. 2020 Jun 26;10(6) PubMed PMID: 32604886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation. A1 - Jossin,Yves, Y1 - 2020/06/26/ PY - 2020/06/09/received PY - 2020/06/24/revised PY - 2020/06/24/accepted PY - 2020/7/2/entrez PY - 2020/7/2/pubmed PY - 2020/7/2/medline KW - Reelin KW - cellular pathways KW - cerebral cortex KW - dendrites KW - embryonic development KW - migration KW - neurodevelopmental disorders KW - neuron KW - postnatal maturation KW - proteolytic processing KW - signal transduction KW - synapse JF - Biomolecules JO - Biomolecules VL - 10 IS - 6 N2 - During embryonic development and adulthood, Reelin exerts several important functions in the brain including the regulation of neuronal migration, dendritic growth and branching, dendritic spine formation, synaptogenesis and synaptic plasticity. As a consequence, the Reelin signaling pathway has been associated with several human brain disorders such as lissencephaly, autism, schizophrenia, bipolar disorder, depression, mental retardation, Alzheimer's disease and epilepsy. Several elements of the signaling pathway are known. Core components, such as the Reelin receptors very low-density lipoprotein receptor (VLDLR) and Apolipoprotein E receptor 2 (ApoER2), Src family kinases Src and Fyn, and the intracellular adaptor Disabled-1 (Dab1), are common to most but not all Reelin functions. Other downstream effectors are, on the other hand, more specific to defined tasks. Reelin is a large extracellular protein, and some aspects of the signal are regulated by its processing into smaller fragments. Rather than being inhibitory, the processing at two major sites seems to be fulfilling important physiological functions. In this review, I describe the various cellular events regulated by Reelin and attempt to explain the current knowledge on the mechanisms of action. After discussing the shared and distinct elements of the Reelin signaling pathway involved in neuronal migration, dendritic growth, spine development and synaptic plasticity, I briefly outline the data revealing the importance of Reelin in human brain disorders. SN - 2218-273X UR - https://www.unboundmedicine.com/medline/citation/32604886/Reelin_Functions,_Mechanisms_of_Action_and_Signaling_Pathways_During_Brain_Development_and_Maturation L2 - https://www.mdpi.com/resolver?pii=biom10060964 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.