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Ribosome Display Technology: Applications in Disease Diagnosis and Control.
Antibodies (Basel). 2020 Jun 27; 9(3)A

Abstract

Antibody ribosome display remains one of the most successful in vitro selection technologies for antibodies fifteen years after it was developed. The unique possibility of direct generation of whole proteins, particularly single-chain antibody fragments (scFvs), has facilitated the establishment of this technology as one of the foremost antibody production methods. Ribosome display has become a vital tool for efficient and low-cost production of antibodies for diagnostics due to its advantageous ability to screen large libraries and generate binders of high affinity. The remarkable flexibility of this method enables its applicability to various platforms. This review focuses on the applications of ribosome display technology in biomedical and agricultural fields in the generation of recombinant scFvs for disease diagnostics and control.

Authors+Show Affiliations

Department of Medicine, Loyola University Medical Center, Chicago, IL 60153, USA.Department of Animal and Environmental Biology, Federal University Oye-Ekiti, Ekiti State 371010, Nigeria.Center for Global Health, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.Department of Medicine, Loyola University Medical Center, Chicago, IL 60153, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32605027

Citation

Kunamneni, Adinarayana, et al. "Ribosome Display Technology: Applications in Disease Diagnosis and Control." Antibodies (Basel, Switzerland), vol. 9, no. 3, 2020.
Kunamneni A, Ogaugwu C, Bradfute S, et al. Ribosome Display Technology: Applications in Disease Diagnosis and Control. Antibodies (Basel). 2020;9(3).
Kunamneni, A., Ogaugwu, C., Bradfute, S., & Durvasula, R. (2020). Ribosome Display Technology: Applications in Disease Diagnosis and Control. Antibodies (Basel, Switzerland), 9(3). https://doi.org/10.3390/antib9030028
Kunamneni A, et al. Ribosome Display Technology: Applications in Disease Diagnosis and Control. Antibodies (Basel). 2020 Jun 27;9(3) PubMed PMID: 32605027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ribosome Display Technology: Applications in Disease Diagnosis and Control. AU - Kunamneni,Adinarayana, AU - Ogaugwu,Christian, AU - Bradfute,Steven, AU - Durvasula,Ravi, Y1 - 2020/06/27/ PY - 2020/04/15/received PY - 2020/06/06/revised PY - 2020/06/08/accepted PY - 2020/7/2/entrez PY - 2020/7/2/pubmed PY - 2020/7/2/medline KW - antibodies KW - diagnostics KW - disease control KW - ribosome display JF - Antibodies (Basel, Switzerland) JO - Antibodies (Basel) VL - 9 IS - 3 N2 - Antibody ribosome display remains one of the most successful in vitro selection technologies for antibodies fifteen years after it was developed. The unique possibility of direct generation of whole proteins, particularly single-chain antibody fragments (scFvs), has facilitated the establishment of this technology as one of the foremost antibody production methods. Ribosome display has become a vital tool for efficient and low-cost production of antibodies for diagnostics due to its advantageous ability to screen large libraries and generate binders of high affinity. The remarkable flexibility of this method enables its applicability to various platforms. This review focuses on the applications of ribosome display technology in biomedical and agricultural fields in the generation of recombinant scFvs for disease diagnostics and control. SN - 2073-4468 UR - https://www.unboundmedicine.com/medline/citation/32605027/Ribosome_Display_Technology:_Applications_in_Disease_Diagnosis_and_Control L2 - https://www.mdpi.com/resolver?pii=antib9030028 DB - PRIME DP - Unbound Medicine ER -
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