Tags

Type your tag names separated by a space and hit enter

TOP mRNPs: Molecular Mechanisms and Principles of Regulation.
Biomolecules. 2020 Jun 27; 10(7)B

Abstract

The cellular response to changes in the surrounding environment and to stress requires the coregulation of gene networks aiming to conserve energy and resources. This is often achieved by downregulating protein synthesis. The 5' Terminal OligoPyrimidine (5' TOP) motif-containing mRNAs, which encode proteins that are essential for protein synthesis, are the primary targets of translational control under stress. The TOP motif is a cis-regulatory RNA element that begins directly after the m7G cap structure and contains the hallmark invariant 5'-cytidine followed by an uninterrupted tract of 4-15 pyrimidines. Regulation of translation via the TOP motif coordinates global protein synthesis with simultaneous co-expression of the protein components required for ribosome biogenesis. In this review, we discuss architecture of TOP mRNA-containing ribonucleoprotein complexes, the principles of their assembly, and the modes of regulation of TOP mRNA translation.

Authors+Show Affiliations

Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.Brigham and Women's Hospital, Harvard Medical School, Harvard Initiative for RNA Medicine, Boston, MA 02115, USA.Brigham and Women's Hospital, Harvard Medical School, Harvard Initiative for RNA Medicine, Boston, MA 02115, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32605040

Citation

Cockman, Eric, et al. "TOP mRNPs: Molecular Mechanisms and Principles of Regulation." Biomolecules, vol. 10, no. 7, 2020.
Cockman E, Anderson P, Ivanov P. TOP mRNPs: Molecular Mechanisms and Principles of Regulation. Biomolecules. 2020;10(7).
Cockman, E., Anderson, P., & Ivanov, P. (2020). TOP mRNPs: Molecular Mechanisms and Principles of Regulation. Biomolecules, 10(7). https://doi.org/10.3390/biom10070969
Cockman E, Anderson P, Ivanov P. TOP mRNPs: Molecular Mechanisms and Principles of Regulation. Biomolecules. 2020 Jun 27;10(7) PubMed PMID: 32605040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TOP mRNPs: Molecular Mechanisms and Principles of Regulation. AU - Cockman,Eric, AU - Anderson,Paul, AU - Ivanov,Pavel, Y1 - 2020/06/27/ PY - 2020/05/21/received PY - 2020/06/20/revised PY - 2020/06/23/accepted PY - 2020/7/2/entrez KW - 5’ Terminal Oligopyrimidine KW - LARP1 KW - RNA KW - RNA binding proteins KW - translation regulation JF - Biomolecules JO - Biomolecules VL - 10 IS - 7 N2 - The cellular response to changes in the surrounding environment and to stress requires the coregulation of gene networks aiming to conserve energy and resources. This is often achieved by downregulating protein synthesis. The 5' Terminal OligoPyrimidine (5' TOP) motif-containing mRNAs, which encode proteins that are essential for protein synthesis, are the primary targets of translational control under stress. The TOP motif is a cis-regulatory RNA element that begins directly after the m7G cap structure and contains the hallmark invariant 5'-cytidine followed by an uninterrupted tract of 4-15 pyrimidines. Regulation of translation via the TOP motif coordinates global protein synthesis with simultaneous co-expression of the protein components required for ribosome biogenesis. In this review, we discuss architecture of TOP mRNA-containing ribonucleoprotein complexes, the principles of their assembly, and the modes of regulation of TOP mRNA translation. SN - 2218-273X UR - https://www.unboundmedicine.com/medline/citation/32605040/TOP_mRNPs:_Molecular_Mechanisms_and_Principles_of_Regulation L2 - https://www.mdpi.com/resolver?pii=biom10070969 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.