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NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy.
Cells. 2020 Jun 28; 9(7)C

Abstract

Muscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities. We previously found that a new neuroprotective drug called NeuroHeal reduced muscle atrophy produced by transient denervation. Aiming to decipher whether NeuroHeal has a direct role in muscle biology, we used herein different models of muscle atrophy: one caused by chronic denervation, another caused by hindlimb immobilization, and lastly, an in vitro model of myotube atrophy with Tumor Necrosis Factor-α (TNFα). In all these models, we observed that NeuroHeal reduced muscle atrophy and that SIRT1 activation seems to be required for that. The treatment downregulated some critical markers of protein degradation: Muscle Ring Finger 1 (MuRF1), K48 poly-Ub chains, and p62/SQSTM1. Moreover, it seems to restore the autophagy flux associated with denervation. Hence, we envisage a prospective use of NeuroHeal at clinics for different myopathies.

Authors+Show Affiliations

Institut de Neurociències (INc) and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona (UAB), Bellaterra, 08193 Barcelona, Spain.Institut de Neurociències (INc) and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona (UAB), Bellaterra, 08193 Barcelona, Spain.Pulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, IMIM-Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona Biomedical Research Park (PRBB), 08003 Barcelona, Spain.Pulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, IMIM-Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona Biomedical Research Park (PRBB), 08003 Barcelona, Spain. Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 08003 Barcelona, Spain.Institut de Neurociències (INc) and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona (UAB), Bellaterra, 08193 Barcelona, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32605216

Citation

Marmolejo-Martínez-Artesero, Sara, et al. "NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy." Cells, vol. 9, no. 7, 2020.
Marmolejo-Martínez-Artesero S, Romeo-Guitart D, Mañas-García L, et al. NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy. Cells. 2020;9(7).
Marmolejo-Martínez-Artesero, S., Romeo-Guitart, D., Mañas-García, L., Barreiro, E., & Casas, C. (2020). NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy. Cells, 9(7). https://doi.org/10.3390/cells9071575
Marmolejo-Martínez-Artesero S, et al. NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy. Cells. 2020 Jun 28;9(7) PubMed PMID: 32605216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy. AU - Marmolejo-Martínez-Artesero,Sara, AU - Romeo-Guitart,David, AU - Mañas-García,Laura, AU - Barreiro,Esther, AU - Casas,Caty, Y1 - 2020/06/28/ PY - 2020/05/15/received PY - 2020/06/23/revised PY - 2020/06/24/accepted PY - 2020/7/2/entrez KW - NeuroHeal KW - autophagy KW - proteasome KW - sirtuin 1 KW - skeletal muscle atrophy JF - Cells JO - Cells VL - 9 IS - 7 N2 - Muscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities. We previously found that a new neuroprotective drug called NeuroHeal reduced muscle atrophy produced by transient denervation. Aiming to decipher whether NeuroHeal has a direct role in muscle biology, we used herein different models of muscle atrophy: one caused by chronic denervation, another caused by hindlimb immobilization, and lastly, an in vitro model of myotube atrophy with Tumor Necrosis Factor-α (TNFα). In all these models, we observed that NeuroHeal reduced muscle atrophy and that SIRT1 activation seems to be required for that. The treatment downregulated some critical markers of protein degradation: Muscle Ring Finger 1 (MuRF1), K48 poly-Ub chains, and p62/SQSTM1. Moreover, it seems to restore the autophagy flux associated with denervation. Hence, we envisage a prospective use of NeuroHeal at clinics for different myopathies. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/32605216/NeuroHeal_Reduces_Muscle_Atrophy_and_Modulates_Associated_Autophagy L2 - https://www.mdpi.com/resolver?pii=cells9071575 DB - PRIME DP - Unbound Medicine ER -
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