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European Association of Urology Guidelines on Primary Urethral Carcinoma-2020 Update.
Eur Urol Oncol. 2020 Jun 27 [Online ahead of print]EU

Abstract

CONTEXT

Primary urethral carcinoma (PUC) is a rare cancer accounting for <1% of all genitourinary malignancies.

OBJECTIVE

To provide updated practical recommendations for the diagnosis and management of PUC.

EVIDENCE ACQUISITION

A systematic search interrogating Ovid (Medline), EMBASE, and the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews was performed.

EVIDENCE SYNTHESIS

Urothelial carcinoma of the urethra is the predominant histological type of PUC (54-65%), followed by squamous cell carcinoma (16-22%) and adenocarcinoma (10-16%). Diagnosis of PUC depends on urethrocystoscopy with biopsy and urinary cytology. Pathological staging and grading are based on the tumour, node, metastasis (TNM) classification and the 2016 World Health Organization grading systems. Local tumour extent and regional lymph nodes are assessed by magnetic resonance imaging, and the presence of distant metastases is assessed by computed tomography of the thorax/abdomen and pelvis. For all patients with localised distal tumours (≤T2N0M0), partial urethrectomy or urethra-sparing surgery is a valid treatment option, provided that negative intraoperative surgical margins can be achieved. Prostatic Ta-Tis-T1 PUC can be treated with repeat transurethral resection of the prostate and bacillus Calmette-Guérin. In prostatic or proximal ≥ T2N0 disease, neoadjuvant cisplatin-based chemotherapy should be considered prior to radical surgery. All patients with locally advanced disease (≥T3N0-2M0) should be discussed within a multidisciplinary team. In men with locally advanced squamous cell carcinoma, curative radiotherapy combined with radiosensitising chemotherapy can be offered for definitive treatment and genital preservation. In patients with local urethral recurrence, salvage surgery or radiotherapy can be offered. For patients with distant metastatic disease, systemic therapy based on tumour characteristics can be evaluated.

CONCLUSIONS

These updated European Association of Urology guidelines provide up-to-date guidance for the contemporary diagnosis and management of patients with suspected PUC.

PATIENT SUMMARY

Primary urethral carcinoma (PUC) is a very rare, but aggressive disease. These updated European Association of Urology guidelines provide evidence-based guidance for clinicians treating patients with PUC.

Authors+Show Affiliations

Department of Urology and Pediatric Urology, University of Würzburg, Würzburg, Germany. Electronic address: georgios.gakis@gmail.com.Department of Urology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, The Netherlands.Department of Medical Oncology, Kantonsspital Graubünden, Chur, Switzerland.Department of Pathology, Sorbonne University, Assistance Publique-Hôpitaux de Paris, Hopital Tenon, Paris, France.Department of Radiology, The Queen Alexandra Hospital, Portsmouth, UK.Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.Department of Urology, Hospital Universitario Fundación Alcorcón, Madrid, Spain.Department of Urology, Hospital Universitario La Paz, Madrid, Spain.Department of Medical Oncology and Hematology, University Hospital Zürich, Zürich, Switzerland.Gustave Roussy Cancer Campus, Villejuif, France; Hopital Foch, Suresnes, France.Uro-Oncology Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain.Gustave Roussy Cancer Campus, Villejuif, France; Hopital Foch, Suresnes, France.Department of Urology, Inselspital, University Hospital Bern, Bern, Switzerland.Department of Urology, Tampere University Hospital, Tampere, Finland.Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32605889

Citation

Gakis, Georgios, et al. "European Association of Urology Guidelines On Primary Urethral Carcinoma-2020 Update." European Urology Oncology, 2020.
Gakis G, Bruins HM, Cathomas R, et al. European Association of Urology Guidelines on Primary Urethral Carcinoma-2020 Update. Eur Urol Oncol. 2020.
Gakis, G., Bruins, H. M., Cathomas, R., Compérat, E. M., Cowan, N. C., van der Heijden, A. G., Hernández, V., Linares Espinós, E. E., Lorch, A., Neuzillet, Y., Ribal, M. J., Rouanne, M., Thalmann, G. N., Veskimäe, E., & Witjes, A. J. (2020). European Association of Urology Guidelines on Primary Urethral Carcinoma-2020 Update. European Urology Oncology. https://doi.org/10.1016/j.euo.2020.06.003
Gakis G, et al. European Association of Urology Guidelines On Primary Urethral Carcinoma-2020 Update. Eur Urol Oncol. 2020 Jun 27; PubMed PMID: 32605889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - European Association of Urology Guidelines on Primary Urethral Carcinoma-2020 Update. AU - Gakis,Georgios, AU - Bruins,Harman M, AU - Cathomas,Richard, AU - Compérat,Eva M, AU - Cowan,Nigel C, AU - van der Heijden,Antoine G, AU - Hernández,Virginia, AU - Linares Espinós,Estefania E, AU - Lorch,Anja, AU - Neuzillet,Yann, AU - Ribal,Maria J, AU - Rouanne,Mathieu, AU - Thalmann,George N, AU - Veskimäe,Erik, AU - Witjes,Alfred J, Y1 - 2020/06/27/ PY - 2020/04/18/received PY - 2020/05/30/revised PY - 2020/06/10/accepted PY - 2020/7/2/entrez KW - Chemotherapy KW - Diagnosis KW - European Association of Urology guidelines KW - Follow-up KW - Management KW - Primary KW - Radiotherapy KW - Recurrence KW - Surgery KW - Systemic therapy KW - Urethral carcinoma JF - European urology oncology JO - Eur Urol Oncol N2 - CONTEXT: Primary urethral carcinoma (PUC) is a rare cancer accounting for <1% of all genitourinary malignancies. OBJECTIVE: To provide updated practical recommendations for the diagnosis and management of PUC. EVIDENCE ACQUISITION: A systematic search interrogating Ovid (Medline), EMBASE, and the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews was performed. EVIDENCE SYNTHESIS: Urothelial carcinoma of the urethra is the predominant histological type of PUC (54-65%), followed by squamous cell carcinoma (16-22%) and adenocarcinoma (10-16%). Diagnosis of PUC depends on urethrocystoscopy with biopsy and urinary cytology. Pathological staging and grading are based on the tumour, node, metastasis (TNM) classification and the 2016 World Health Organization grading systems. Local tumour extent and regional lymph nodes are assessed by magnetic resonance imaging, and the presence of distant metastases is assessed by computed tomography of the thorax/abdomen and pelvis. For all patients with localised distal tumours (≤T2N0M0), partial urethrectomy or urethra-sparing surgery is a valid treatment option, provided that negative intraoperative surgical margins can be achieved. Prostatic Ta-Tis-T1 PUC can be treated with repeat transurethral resection of the prostate and bacillus Calmette-Guérin. In prostatic or proximal ≥ T2N0 disease, neoadjuvant cisplatin-based chemotherapy should be considered prior to radical surgery. All patients with locally advanced disease (≥T3N0-2M0) should be discussed within a multidisciplinary team. In men with locally advanced squamous cell carcinoma, curative radiotherapy combined with radiosensitising chemotherapy can be offered for definitive treatment and genital preservation. In patients with local urethral recurrence, salvage surgery or radiotherapy can be offered. For patients with distant metastatic disease, systemic therapy based on tumour characteristics can be evaluated. CONCLUSIONS: These updated European Association of Urology guidelines provide up-to-date guidance for the contemporary diagnosis and management of patients with suspected PUC. PATIENT SUMMARY: Primary urethral carcinoma (PUC) is a very rare, but aggressive disease. These updated European Association of Urology guidelines provide evidence-based guidance for clinicians treating patients with PUC. SN - 2588-9311 UR - https://www.unboundmedicine.com/medline/citation/32605889/European_Association_of_Urology_Guidelines_on_Primary_Urethral_Carcinoma-2020_Update L2 - https://linkinghub.elsevier.com/retrieve/pii/S2588-9311(20)30081-X DB - PRIME DP - Unbound Medicine ER -
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