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Salvage Photon or Proton Radiotherapy for Oligo-recurrence in Regional Lymph Nodes After Surgery for Non-small Cell Lung Cancer.
In Vivo. 2020 Jul-Aug; 34(4):1883-1892.V

Abstract

BACKGROUND/AIM

To evaluate the outcome of definitive salvage radiotherapy (RT) in non-small cell lung cancer (NSCLC) patients with oligo-recurrence in regional lymph nodes after surgery.

PATIENTS AND METHODS

Between January 2003 and December 2016, 33 patients with NSCLC were reviewed from radiotherapy database at our hospital. All patients received photon or proton salvage RT for metastases in the regional lymph nodes.

RESULTS

The median follow-up from salvage RT was 35.2 (range=5.9-89.6) months. Recurrences occurred in 18 (55%) patients, and the 3-year overall and progression-free survival rates were 63.8% and 45.1%, respectively. Regional and local control improved patients' survival and these control rates were increased by use of concurrent chemotherapy (p=0.039) and proton RT (p=0.084). No grade 4 acute or late non-hematologic toxicities were observed.

CONCLUSION

Salvage RT is an effective treatment for NSCLC patients with oligo-recurrence at regional lymph nodes.

Authors+Show Affiliations

Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan ohnishi@pmrc.tsukuba.ac.jp.Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Medical Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Thoracic Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32606159

Citation

Nakamura, Masatoshi, et al. "Salvage Photon or Proton Radiotherapy for Oligo-recurrence in Regional Lymph Nodes After Surgery for Non-small Cell Lung Cancer." In Vivo (Athens, Greece), vol. 34, no. 4, 2020, pp. 1883-1892.
Nakamura M, Ohnishi K, Ishikawa H, et al. Salvage Photon or Proton Radiotherapy for Oligo-recurrence in Regional Lymph Nodes After Surgery for Non-small Cell Lung Cancer. In Vivo. 2020;34(4):1883-1892.
Nakamura, M., Ohnishi, K., Ishikawa, H., Nakazawa, K., Shiozawa, T., Okumura, T., Sekine, I., Sato, Y., Hizawa, N., & Sakurai, H. (2020). Salvage Photon or Proton Radiotherapy for Oligo-recurrence in Regional Lymph Nodes After Surgery for Non-small Cell Lung Cancer. In Vivo (Athens, Greece), 34(4), 1883-1892. https://doi.org/10.21873/invivo.11984
Nakamura M, et al. Salvage Photon or Proton Radiotherapy for Oligo-recurrence in Regional Lymph Nodes After Surgery for Non-small Cell Lung Cancer. In Vivo. 2020 Jul-Aug;34(4):1883-1892. PubMed PMID: 32606159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salvage Photon or Proton Radiotherapy for Oligo-recurrence in Regional Lymph Nodes After Surgery for Non-small Cell Lung Cancer. AU - Nakamura,Masatoshi, AU - Ohnishi,Kayoko, AU - Ishikawa,Hitoshi, AU - Nakazawa,Kensuke, AU - Shiozawa,Toshihiro, AU - Okumura,Toshiyuki, AU - Sekine,Ikuo, AU - Sato,Yukio, AU - Hizawa,Nobuyuki, AU - Sakurai,Hideyuki, PY - 2020/03/08/received PY - 2020/04/03/revised PY - 2020/04/06/accepted PY - 2020/7/2/entrez KW - Radiotherapy KW - lymph node metastasis KW - non-small cell lung cancer KW - oligo-recurrence SP - 1883 EP - 1892 JF - In vivo (Athens, Greece) JO - In Vivo VL - 34 IS - 4 N2 - BACKGROUND/AIM: To evaluate the outcome of definitive salvage radiotherapy (RT) in non-small cell lung cancer (NSCLC) patients with oligo-recurrence in regional lymph nodes after surgery. PATIENTS AND METHODS: Between January 2003 and December 2016, 33 patients with NSCLC were reviewed from radiotherapy database at our hospital. All patients received photon or proton salvage RT for metastases in the regional lymph nodes. RESULTS: The median follow-up from salvage RT was 35.2 (range=5.9-89.6) months. Recurrences occurred in 18 (55%) patients, and the 3-year overall and progression-free survival rates were 63.8% and 45.1%, respectively. Regional and local control improved patients' survival and these control rates were increased by use of concurrent chemotherapy (p=0.039) and proton RT (p=0.084). No grade 4 acute or late non-hematologic toxicities were observed. CONCLUSION: Salvage RT is an effective treatment for NSCLC patients with oligo-recurrence at regional lymph nodes. SN - 1791-7549 UR - https://www.unboundmedicine.com/medline/citation/32606159/Salvage_Photon_or_Proton_Radiotherapy_for_Oligo-recurrence_in_Regional_Lymph_Nodes_After_Surgery_for_Non-small_Cell_Lung_Cancer L2 - http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=32606159 DB - PRIME DP - Unbound Medicine ER -
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