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COVID-19 meets Cystic Fibrosis: for better or worse?
Genes Immun. 2020 08; 21(4):260-262.GI

Abstract

Cystic fibrosis (CF) is one of the most common autosomal recessive life-limiting conditions affecting Caucasians. The resulting defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) results in defective chloride and bicarbonate secretion, as well as dysregulation of epithelial sodium channels (ENaC). These changes bring about defective mucociliary clearance, reduced airway surface liquid and an exaggerated proinflammatory response driven, in part, by infection. In this short article we explore the overlap in the pathophysiology of CF and COVID-19 infection and discuss how understanding the interaction between both diseases may shed light on future treatments.

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Authors+Show Affiliations

Peckham D
Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. d.g.peckham@leeds.ac.uk.
McDermott MF
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
Savic S
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
Mehta A
Division of Medical Sciences, University of Dundee, Dundee, UK.

MeSH

Angiotensin-Converting Enzyme 2AnimalsCOVID-19Coronavirus InfectionsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorCytokinesHumansPandemicsPeptidyl-Dipeptidase APneumonia, Viral

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32606316

Clinical Trial Links

COVID-19 Antibody Responses In Cystic Fibrosis

Citation

Peckham, Daniel, et al. "COVID-19 Meets Cystic Fibrosis: for Better or Worse?" Genes and Immunity, vol. 21, no. 4, 2020, pp. 260-262.
Peckham D, McDermott MF, Savic S, et al. COVID-19 meets Cystic Fibrosis: for better or worse? Genes Immun. 2020;21(4):260-262.
Peckham, D., McDermott, M. F., Savic, S., & Mehta, A. (2020). COVID-19 meets Cystic Fibrosis: for better or worse? Genes and Immunity, 21(4), 260-262. https://doi.org/10.1038/s41435-020-0103-y
Peckham D, et al. COVID-19 Meets Cystic Fibrosis: for Better or Worse. Genes Immun. 2020;21(4):260-262. PubMed PMID: 32606316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 meets Cystic Fibrosis: for better or worse? AU - Peckham,Daniel, AU - McDermott,Michael F, AU - Savic,Sinisa, AU - Mehta,Anil, Y1 - 2020/07/01/ PY - 2020/06/17/revised PY - 2020/7/2/pubmed PY - 2020/9/12/medline PY - 2020/7/2/entrez SP - 260 EP - 262 JF - Genes and immunity JO - Genes Immun VL - 21 IS - 4 N2 - Cystic fibrosis (CF) is one of the most common autosomal recessive life-limiting conditions affecting Caucasians. The resulting defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) results in defective chloride and bicarbonate secretion, as well as dysregulation of epithelial sodium channels (ENaC). These changes bring about defective mucociliary clearance, reduced airway surface liquid and an exaggerated proinflammatory response driven, in part, by infection. In this short article we explore the overlap in the pathophysiology of CF and COVID-19 infection and discuss how understanding the interaction between both diseases may shed light on future treatments. SN - 1476-5470 UR - https://www.unboundmedicine.com/medline/citation/32606316/COVID_19_meets_Cystic_Fibrosis:_for_better_or_worse L2 - https://doi.org/10.1038/s41435-020-0103-y DB - PRIME DP - Unbound Medicine ER -