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Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum.
Int J Nanomedicine. 2020; 15:4351-4362.IJ

Abstract

Purpose

The present study synthesized silver nanoparticles (AgNPs) using the aqueous extract of a traditional medicinal product consisting of an oleoresin (a combination of macromolecules of carbohydrates and proteins) exuded from the rhizome of the plant Ferula foetida (asafoetida gum) and evaluated its biological properties.

Materials and Methods

The silver nanoparticles synthesized using asafoetida gum (As-AgNPs) were characterized using UV/Vis spectroscopy, fourier infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and transmission electron microscopy (TEM) and EADX. The cytotoxicity and antimicrobial activity As-AgNPs were evaluated against MCF-7 cell lines and selected microbial pathogens, respectively.

Results

The synthesized silver nanoparticles were crystalline in nature with a spherical shape. The average particle size was 5.6-8.6 nm. The cytotoxicity of the synthesized As-AgNPs was evaluated against MCF-7 cell lines, and the As-AgNPs were found to be effective in inhibiting the multiplication of cancer cells. The As-AgNPs exhibited significant antimicrobial activity towards E. coli, K. pneumoniae and C. albicans. The MIC of the synthesized As-AgNPs was 7.80 μg/mL for E. coli ATCC 25922, Salmonella sp. WS50- and S. typhi; 15.60 μg/mL for S. typhimurium and S. aureus WS10, and 31.20 μg/mL for K. pneumoniae and S. aureus ATCC 43300-MRSA. In addition, MIC values of 15.60 μg/mL for C. albicans ATCC8436 and 31.20 μg/mL for C. krusei ATCC6258 were obtained.

Conclusion

As asafoetida is a good traditional medicine, its involvement in the synthesis of AgNPs led the silver nanoparticles to exhibit good cytotoxic and antimicrobial effects.

Authors+Show Affiliations

Research Chair in Laser Diagnosis of Cancer, Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia. Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia.Department of Botany and Microbiology, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.Research Chair in Laser Diagnosis of Cancer, Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia. Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia.Department of Botany and Microbiology, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32606682

Citation

Devanesan, Sandhanasamy, et al. "Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum." International Journal of Nanomedicine, vol. 15, 2020, pp. 4351-4362.
Devanesan S, Ponmurugan K, AlSalhi MS, et al. Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum. Int J Nanomedicine. 2020;15:4351-4362.
Devanesan, S., Ponmurugan, K., AlSalhi, M. S., & Al-Dhabi, N. A. (2020). Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum. International Journal of Nanomedicine, 15, 4351-4362. https://doi.org/10.2147/IJN.S258319
Devanesan S, et al. Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum. Int J Nanomedicine. 2020;15:4351-4362. PubMed PMID: 32606682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum. AU - Devanesan,Sandhanasamy, AU - Ponmurugan,Karuppiah, AU - AlSalhi,Mohamad S, AU - Al-Dhabi,Naif Abdullah, Y1 - 2020/06/19/ PY - 2020/04/28/received PY - 2020/06/09/accepted PY - 2020/7/2/entrez PY - 2020/7/2/pubmed PY - 2020/8/15/medline KW - AgNPs KW - antimicrobial KW - asafoetida gum KW - biomedical agent KW - cytotoxicity SP - 4351 EP - 4362 JF - International journal of nanomedicine JO - Int J Nanomedicine VL - 15 N2 - Purpose: The present study synthesized silver nanoparticles (AgNPs) using the aqueous extract of a traditional medicinal product consisting of an oleoresin (a combination of macromolecules of carbohydrates and proteins) exuded from the rhizome of the plant Ferula foetida (asafoetida gum) and evaluated its biological properties. Materials and Methods: The silver nanoparticles synthesized using asafoetida gum (As-AgNPs) were characterized using UV/Vis spectroscopy, fourier infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and transmission electron microscopy (TEM) and EADX. The cytotoxicity and antimicrobial activity As-AgNPs were evaluated against MCF-7 cell lines and selected microbial pathogens, respectively. Results: The synthesized silver nanoparticles were crystalline in nature with a spherical shape. The average particle size was 5.6-8.6 nm. The cytotoxicity of the synthesized As-AgNPs was evaluated against MCF-7 cell lines, and the As-AgNPs were found to be effective in inhibiting the multiplication of cancer cells. The As-AgNPs exhibited significant antimicrobial activity towards E. coli, K. pneumoniae and C. albicans. The MIC of the synthesized As-AgNPs was 7.80 μg/mL for E. coli ATCC 25922, Salmonella sp. WS50- and S. typhi; 15.60 μg/mL for S. typhimurium and S. aureus WS10, and 31.20 μg/mL for K. pneumoniae and S. aureus ATCC 43300-MRSA. In addition, MIC values of 15.60 μg/mL for C. albicans ATCC8436 and 31.20 μg/mL for C. krusei ATCC6258 were obtained. Conclusion: As asafoetida is a good traditional medicine, its involvement in the synthesis of AgNPs led the silver nanoparticles to exhibit good cytotoxic and antimicrobial effects. SN - 1178-2013 UR - https://www.unboundmedicine.com/medline/citation/32606682/Cytotoxic_and_Antimicrobial_Efficacy_of_Silver_Nanoparticles_Synthesized_Using_a_Traditional_Phytoproduct_Asafoetida_Gum_ DB - PRIME DP - Unbound Medicine ER -