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Combination of CA19-9 and the Neutrophil-to-Lymphocyte Ratio for the Differential Diagnosis of Gallbladder Carcinoma.
Cancer Manag Res. 2020; 12:4475-4482.CM

Abstract

Purpose

This study aimed to evaluate the efficiency of several parameters, including the neutrophil-to-lymphocyte ratio (NLR) obtained from preoperative routine blood examination, either alone or as an adjunct to the carbohydrate antigen 19-9 (CA19-9), for the diagnosis of gallbladder carcinoma (GBC).

Patients and Methods

Data from 123 patients with gallbladder cholesterol polyps (GCP), 80 with gallbladder adenoma (GA), and 103 with GBC were reviewed retrospectively. Receiver operating characteristic analysis was used to assess the sensitivity, specificity, and clinical value of the NLR, CA19-9, and their combination.

Results

Values of measured indicators were significantly higher in GBC patients than in GCP or GA patients but there were no significant differences between GCP and GA patients. The combination of NLR and CA19-9 had the best diagnostic efficiency for differentiating GBC from benign lesions with 74.8% sensitivity and 89.7% specificity. However, the NLR showed no significant difference between mid-to-advanced stage and early-to-mid stage GBC. The combination of NLR and CA19-9 (53.7% sensitivity and 88.9% specificity) did not reveal any advantages over CA19-9 alone (63.0% sensitivity and 89.0% specificity) in distinguishing different stages of GBC.

Conclusion

NLR and CA19-9, and their combination-parameters that are easily obtained preoperatively-have potential as diagnostic markers for GBC.

Authors+Show Affiliations

Department of General Surgery, Peking University First Hospital, Peking University, Beijing, People's Republic of China.Department of General Surgery, Peking University First Hospital, Peking University, Beijing, People's Republic of China.Department of General Surgery, Peking University First Hospital, Peking University, Beijing, People's Republic of China.Department of General Surgery, Peking University First Hospital, Peking University, Beijing, People's Republic of China.Department of General Surgery, Peking University First Hospital, Peking University, Beijing, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32606941

Citation

Chen, Zeyang, et al. "Combination of CA19-9 and the Neutrophil-to-Lymphocyte Ratio for the Differential Diagnosis of Gallbladder Carcinoma." Cancer Management and Research, vol. 12, 2020, pp. 4475-4482.
Chen Z, Liu Z, Zhang Y, et al. Combination of CA19-9 and the Neutrophil-to-Lymphocyte Ratio for the Differential Diagnosis of Gallbladder Carcinoma. Cancer Manag Res. 2020;12:4475-4482.
Chen, Z., Liu, Z., Zhang, Y., Wang, P., & Gao, H. (2020). Combination of CA19-9 and the Neutrophil-to-Lymphocyte Ratio for the Differential Diagnosis of Gallbladder Carcinoma. Cancer Management and Research, 12, 4475-4482. https://doi.org/10.2147/CMAR.S255480
Chen Z, et al. Combination of CA19-9 and the Neutrophil-to-Lymphocyte Ratio for the Differential Diagnosis of Gallbladder Carcinoma. Cancer Manag Res. 2020;12:4475-4482. PubMed PMID: 32606941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of CA19-9 and the Neutrophil-to-Lymphocyte Ratio for the Differential Diagnosis of Gallbladder Carcinoma. AU - Chen,Zeyang, AU - Liu,Zining, AU - Zhang,Yuyang, AU - Wang,Pengyuan, AU - Gao,Hongqiao, Y1 - 2020/06/12/ PY - 2020/04/02/received PY - 2020/05/26/accepted PY - 2020/7/2/entrez PY - 2020/7/2/pubmed PY - 2020/7/2/medline KW - CA19-9 KW - diagnosis KW - gallbladder cancer KW - neutrophil-to-lymphocyte ratio SP - 4475 EP - 4482 JF - Cancer management and research JO - Cancer Manag Res VL - 12 N2 - Purpose: This study aimed to evaluate the efficiency of several parameters, including the neutrophil-to-lymphocyte ratio (NLR) obtained from preoperative routine blood examination, either alone or as an adjunct to the carbohydrate antigen 19-9 (CA19-9), for the diagnosis of gallbladder carcinoma (GBC). Patients and Methods: Data from 123 patients with gallbladder cholesterol polyps (GCP), 80 with gallbladder adenoma (GA), and 103 with GBC were reviewed retrospectively. Receiver operating characteristic analysis was used to assess the sensitivity, specificity, and clinical value of the NLR, CA19-9, and their combination. Results: Values of measured indicators were significantly higher in GBC patients than in GCP or GA patients but there were no significant differences between GCP and GA patients. The combination of NLR and CA19-9 had the best diagnostic efficiency for differentiating GBC from benign lesions with 74.8% sensitivity and 89.7% specificity. However, the NLR showed no significant difference between mid-to-advanced stage and early-to-mid stage GBC. The combination of NLR and CA19-9 (53.7% sensitivity and 88.9% specificity) did not reveal any advantages over CA19-9 alone (63.0% sensitivity and 89.0% specificity) in distinguishing different stages of GBC. Conclusion: NLR and CA19-9, and their combination-parameters that are easily obtained preoperatively-have potential as diagnostic markers for GBC. SN - 1179-1322 UR - https://www.unboundmedicine.com/medline/citation/32606941/Combination_of_CA19-9_and_the_Neutrophil-to-Lymphocyte_Ratio_for_the_Differential_Diagnosis_of_Gallbladder_Carcinoma L2 - https://dx.doi.org/10.2147/CMAR.S255480 DB - PRIME DP - Unbound Medicine ER -
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