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Combating the Coronavirus Pandemic: Early Detection, Medical Treatment, and a Concerted Effort by the Global Community.
Research (Wash D C). 2020; 2020:6925296.R

Abstract

The World Health Organization (WHO) has declared the outbreak of 2019 novel coronavirus, known as 2019-nCoV, a pandemic, as the coronavirus has now infected over 2.6 million people globally and caused more than 185,000 fatalities as of April 23, 2020. Coronavirus disease 2019 (COVID-19) causes a respiratory illness with symptoms such as dry cough, fever, sudden loss of smell, and, in more severe cases, difficulty breathing. To date, there is no specific vaccine or treatment proven effective against this viral disease. Early and accurate diagnosis of COVID-19 is thus critical to curbing its spread and improving health outcomes. Reverse transcription-polymerase chain reaction (RT-PCR) is commonly used to detect the presence of COVID-19. Other techniques, such as recombinase polymerase amplification (RPA), loop-mediated isothermal amplification (LAMP), clustered regularly interspaced short palindromic repeats (CRISPR), and microfluidics, have allowed better disease diagnosis. Here, as part of the effort to expand screening capacity, we review advances and challenges in the rapid detection of COVID-19 by targeting nucleic acids, antigens, or antibodies. We also summarize potential treatments and vaccines against COVID-19 and discuss ongoing clinical trials of interventions to reduce viral progression.

Authors+Show Affiliations

Department of Chemistry, National University of Singapore, Singapore 117543, Singapore.Department of Chemistry, National University of Singapore, Singapore 117543, Singapore. NUS Graduate School for Integrative Sciences and Engineering, Singapore 117456, Singapore.Frontiers Science Center for Flexible Electronics & Shaanxi Institute of Flexible Electronics, Northwestern Polytechnical University, Xi'an 710072, China.Department of Chemistry, National University of Singapore, Singapore 117543, Singapore.Department of Chemistry, National University of Singapore, Singapore 117543, Singapore. NUS Graduate School for Integrative Sciences and Engineering, Singapore 117456, Singapore.Department of Chemistry, National University of Singapore, Singapore 117543, Singapore.Sports Medical Centre, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China.State Key Laboratory of Rare Earth Resource Utilization, Chang Chun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.Department of Oncology, The Fourth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100048, China.State Key Laboratory of Rare Earth Resource Utilization, Chang Chun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Department of Chemistry, Tsinghua University, Beijing 100084, China.Frontiers Science Center for Flexible Electronics & Shaanxi Institute of Flexible Electronics, Northwestern Polytechnical University, Xi'an 710072, China. Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University, Nanjing 211816, China.Department of Chemistry, National University of Singapore, Singapore 117543, Singapore. The N.1 Institute for Health, National University of Singapore, Singapore. Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Fuzhou 350807, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32607499

Citation

Luo, Zichao, et al. "Combating the Coronavirus Pandemic: Early Detection, Medical Treatment, and a Concerted Effort By the Global Community." Research (Washington, D.C.), vol. 2020, 2020, p. 6925296.
Luo Z, Ang MJY, Chan SY, et al. Combating the Coronavirus Pandemic: Early Detection, Medical Treatment, and a Concerted Effort by the Global Community. Research (Wash D C). 2020;2020:6925296.
Luo, Z., Ang, M. J. Y., Chan, S. Y., Yi, Z., Goh, Y. Y., Yan, S., Tao, J., Liu, K., Li, X., Zhang, H., Huang, W., & Liu, X. (2020). Combating the Coronavirus Pandemic: Early Detection, Medical Treatment, and a Concerted Effort by the Global Community. Research (Washington, D.C.), 2020, 6925296. https://doi.org/10.34133/2020/6925296
Luo Z, et al. Combating the Coronavirus Pandemic: Early Detection, Medical Treatment, and a Concerted Effort By the Global Community. Research (Wash D C). 2020;2020:6925296. PubMed PMID: 32607499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combating the Coronavirus Pandemic: Early Detection, Medical Treatment, and a Concerted Effort by the Global Community. AU - Luo,Zichao, AU - Ang,Melgious Jin Yan, AU - Chan,Siew Yin, AU - Yi,Zhigao, AU - Goh,Yi Yiing, AU - Yan,Shuangqian, AU - Tao,Jun, AU - Liu,Kai, AU - Li,Xiaosong, AU - Zhang,Hongjie, AU - Huang,Wei, AU - Liu,Xiaogang, Y1 - 2020/06/16/ PY - 2020/04/19/received PY - 2020/04/20/accepted PY - 2020/7/2/entrez PY - 2020/7/2/pubmed PY - 2020/7/2/medline SP - 6925296 EP - 6925296 JF - Research (Washington, D.C.) JO - Research (Wash D C) VL - 2020 N2 - The World Health Organization (WHO) has declared the outbreak of 2019 novel coronavirus, known as 2019-nCoV, a pandemic, as the coronavirus has now infected over 2.6 million people globally and caused more than 185,000 fatalities as of April 23, 2020. Coronavirus disease 2019 (COVID-19) causes a respiratory illness with symptoms such as dry cough, fever, sudden loss of smell, and, in more severe cases, difficulty breathing. To date, there is no specific vaccine or treatment proven effective against this viral disease. Early and accurate diagnosis of COVID-19 is thus critical to curbing its spread and improving health outcomes. Reverse transcription-polymerase chain reaction (RT-PCR) is commonly used to detect the presence of COVID-19. Other techniques, such as recombinase polymerase amplification (RPA), loop-mediated isothermal amplification (LAMP), clustered regularly interspaced short palindromic repeats (CRISPR), and microfluidics, have allowed better disease diagnosis. Here, as part of the effort to expand screening capacity, we review advances and challenges in the rapid detection of COVID-19 by targeting nucleic acids, antigens, or antibodies. We also summarize potential treatments and vaccines against COVID-19 and discuss ongoing clinical trials of interventions to reduce viral progression. SN - 2639-5274 UR - https://www.unboundmedicine.com/medline/citation/32607499/Combating_the_Coronavirus_Pandemic:_Early_Detection,_Medical_Treatment,_and_a_Concerted_Effort_by_the_Global_Community L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32607499/ DB - PRIME DP - Unbound Medicine ER -
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