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Hypervitaminosis A is associated with immunological non-response in HIV-1-infected adults: a case-control study.
Eur J Clin Microbiol Infect Dis. 2020 Jun 30 [Online ahead of print]EJ

Abstract

For people living with HIV, determinants of immunological non-response (INR) to combined antiretroviral therapy (cART) have not been fully elucidated. In a case-control study, we evaluated the influence of the nutritional and antioxidant status in HIV-1 adults whose cART was initiated between January 2001 and December 2013. Cases had persistent CD4 counts < 350/μL vs. > 350/μL for controls, after at least 2 years of cART with persistent viral loads (VL) < 50 copies/mL. Twelve cases and twenty-eight control subjects with the same CD4 count at cART initiation were compared for their nutritional and antioxidant status after age adjustment at dosage assessment. Patients were predominantly male (70%), Caucasian (82%) and at AIDS stage (62%). The median age was 53, and the median CD4 count was 245/mm3 for cases and 630/mm3 for controls after a median time of 7 years on cART. Despite higher energy intakes in cases, anthropometric data was comparable between groups who had similar vitamins B9/B12/C/D/E, zinc, citrulline and glutamine levels. Nine cases (75%) and 8 controls (29%) had hypervitaminosis A (> 2.70 μmol/L) (p = 0.030). Cases had lower erythrocyte resistance when exposed to a controlled free radical attack (p = 0.014). Most cases had hypervitaminosis A and altered antioxidant capacities that could affect immunological response. Wide-scale studies are required, but in the meantime, screening of their vitamin A status must be encouraged in these patients.

Authors+Show Affiliations

Hôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France. hugues.melliez@outlook.fr. Hôpital de la région de Saint-Omer, Service de médecine interne, Helfaut, France. hugues.melliez@outlook.fr.Laboratoire LARA SPIRAL, Couternon, France.CHU Lille, ULR 2694 - METRICS: Évaluation des technologies de santé et des pratiques médicales, University Lille, F-59000, Lille, France.Service de Biochimie, Hôpital Cochin, APHP et Service de Nutrition, Faculté de Pharmacie, Université de Paris, Paris, France.Biochimie hormonologie, Hôpital Universitaire Robert Debré APHP, Paris, France. Lip (Sys)2, Université Paris-Sud, Chatenay Malabry, France.Centre de Pathologies-Biologie, CHRU de Lille, Lille, France.Hôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France.Hôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France.Laboratoire d'Analyses Médicales, CH Dron, Tourcoing, France.Hôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France.Hôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France.Service de Biochimie, Hôpital Cochin, APHP et Service de Nutrition, Faculté de Pharmacie, Université de Paris, Paris, France.Hôpital Gustave Dron, Service universitaire des maladies infectieuses et du voyageur, Tourcoing, France.U1286 - Infinite - Institute for Translational Research in Inflammation, University Lille, F-59000, Lille, France. Inserm, U1286, F-59000, Lille, France. CHU Lille, Endocrinologie, Diabétologie, Maladies Métabolique et Nutrition, F-59000, Lille, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32607910

Citation

Melliez, Hugues, et al. "Hypervitaminosis a Is Associated With Immunological Non-response in HIV-1-infected Adults: a Case-control Study." European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, 2020.
Melliez H, Prost M, Behal H, et al. Hypervitaminosis A is associated with immunological non-response in HIV-1-infected adults: a case-control study. Eur J Clin Microbiol Infect Dis. 2020.
Melliez, H., Prost, M., Behal, H., Neveux, N., Benoist, J. F., Kim, I., Mazzella, S., Derdour, V., Sauser, E., Robineau, O., Senneville, E., Cynober, L., Biekre, R., & Seguy, D. (2020). Hypervitaminosis A is associated with immunological non-response in HIV-1-infected adults: a case-control study. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology. https://doi.org/10.1007/s10096-020-03954-0
Melliez H, et al. Hypervitaminosis a Is Associated With Immunological Non-response in HIV-1-infected Adults: a Case-control Study. Eur J Clin Microbiol Infect Dis. 2020 Jun 30; PubMed PMID: 32607910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypervitaminosis A is associated with immunological non-response in HIV-1-infected adults: a case-control study. AU - Melliez,Hugues, AU - Prost,Michel, AU - Behal,Hélène, AU - Neveux,Nathalie, AU - Benoist,Jean-François, AU - Kim,Isabelle, AU - Mazzella,Sylvie, AU - Derdour,Vincent, AU - Sauser,Evelyne, AU - Robineau,Olivier, AU - Senneville,Eric, AU - Cynober,Luc, AU - Biekre,Raphaël, AU - Seguy,David, Y1 - 2020/06/30/ PY - 2020/03/01/received PY - 2020/06/15/accepted PY - 2020/7/2/entrez KW - Antioxidant status KW - HIV KW - Hypervitaminosis A KW - Immunological non-response KW - Nutrition JF - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology JO - Eur. J. Clin. Microbiol. Infect. Dis. N2 - For people living with HIV, determinants of immunological non-response (INR) to combined antiretroviral therapy (cART) have not been fully elucidated. In a case-control study, we evaluated the influence of the nutritional and antioxidant status in HIV-1 adults whose cART was initiated between January 2001 and December 2013. Cases had persistent CD4 counts < 350/μL vs. > 350/μL for controls, after at least 2 years of cART with persistent viral loads (VL) < 50 copies/mL. Twelve cases and twenty-eight control subjects with the same CD4 count at cART initiation were compared for their nutritional and antioxidant status after age adjustment at dosage assessment. Patients were predominantly male (70%), Caucasian (82%) and at AIDS stage (62%). The median age was 53, and the median CD4 count was 245/mm3 for cases and 630/mm3 for controls after a median time of 7 years on cART. Despite higher energy intakes in cases, anthropometric data was comparable between groups who had similar vitamins B9/B12/C/D/E, zinc, citrulline and glutamine levels. Nine cases (75%) and 8 controls (29%) had hypervitaminosis A (> 2.70 μmol/L) (p = 0.030). Cases had lower erythrocyte resistance when exposed to a controlled free radical attack (p = 0.014). Most cases had hypervitaminosis A and altered antioxidant capacities that could affect immunological response. Wide-scale studies are required, but in the meantime, screening of their vitamin A status must be encouraged in these patients. SN - 1435-4373 UR - https://www.unboundmedicine.com/medline/citation/32607910/Hypervitaminosis_A_is_associated_with_immunological_non-response_in_HIV-1-infected_adults:_a_case-control_study L2 - https://dx.doi.org/10.1007/s10096-020-03954-0 DB - PRIME DP - Unbound Medicine ER -
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