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Nanogels with selective intracellular reactivity for intracellular tracking and delivery.
Chemistry. 2020 Jul 01 [Online ahead of print]C

Abstract

A multimodal approach for hydrogel-based nanoparticles was developed to selectively allow molecular conjugated species to either be released inside the cell or remain connected to the polymer network. Using the intrinsic difference in reactivity between esters and amides, nanogels with an amide-conjugated dye could be tracked intracellularly localizing next to the nucleus, while ester-conjugation allowed for liberation of the molecular species from the hydrogel network inside the cell, enabling delivery throughout the cytoplasm. The release was a result of particle exposure to the intracellular environment. The conjugation approach and polymer network building rely on the same chemistry and provide a diverse range of possibilities to be used in nanomedicine and theranostic approaches.

Authors+Show Affiliations

Universitair Medisch Centrum Groningen, Biomedical Engineering, NETHERLANDS.Universitair Medisch Centrum Groningen, Biomedical Engineering, NETHERLANDS.Universitair Medisch Centrum Groningen, Biomedical Engineering, NETHERLANDS.Universitair Medisch Centrum Groningen, Biomedical Engineering, NETHERLANDS.Universitair Medisch Centrum Groningen, Biomedical Engineering, NETHERLANDS.University of Groningen, University Medical Center Groningen, Depart. of Biomed. Eng., W.J. Kolff Institute for Biomed. Eng. and Materials Sci, A. Deusinglaan 1, 9713 AV, Groningen, NETHERLANDS.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32608127

Citation

Zu, Guangyue, et al. "Nanogels With Selective Intracellular Reactivity for Intracellular Tracking and Delivery." Chemistry (Weinheim an Der Bergstrasse, Germany), 2020.
Zu G, Mergel O, Ribovski L, et al. Nanogels with selective intracellular reactivity for intracellular tracking and delivery. Chemistry. 2020.
Zu, G., Mergel, O., Ribovski, L., Bron, R., Zuhorn, I., & van Rijn, P. (2020). Nanogels with selective intracellular reactivity for intracellular tracking and delivery. Chemistry (Weinheim an Der Bergstrasse, Germany). https://doi.org/10.1002/chem.202001802
Zu G, et al. Nanogels With Selective Intracellular Reactivity for Intracellular Tracking and Delivery. Chemistry. 2020 Jul 1; PubMed PMID: 32608127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nanogels with selective intracellular reactivity for intracellular tracking and delivery. AU - Zu,Guangyue, AU - Mergel,Olga, AU - Ribovski,Lais, AU - Bron,Reinier, AU - Zuhorn,Inge, AU - van Rijn,Patrick, Y1 - 2020/07/01/ PY - 2020/04/14/received PY - 2020/06/30/accepted PY - 2020/06/25/revised PY - 2020/7/2/entrez KW - Hydrolysis KW - controlled release KW - delivery KW - multimodal KW - nanogel JF - Chemistry (Weinheim an der Bergstrasse, Germany) JO - Chemistry N2 - A multimodal approach for hydrogel-based nanoparticles was developed to selectively allow molecular conjugated species to either be released inside the cell or remain connected to the polymer network. Using the intrinsic difference in reactivity between esters and amides, nanogels with an amide-conjugated dye could be tracked intracellularly localizing next to the nucleus, while ester-conjugation allowed for liberation of the molecular species from the hydrogel network inside the cell, enabling delivery throughout the cytoplasm. The release was a result of particle exposure to the intracellular environment. The conjugation approach and polymer network building rely on the same chemistry and provide a diverse range of possibilities to be used in nanomedicine and theranostic approaches. SN - 1521-3765 UR - https://www.unboundmedicine.com/medline/citation/32608127/Nanogels_with_selective_intracellular_reactivity_for_intracellular_tracking_and_delivery L2 - https://doi.org/10.1002/chem.202001802 DB - PRIME DP - Unbound Medicine ER -
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