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The protective effects of different compatibility proportions of the couplet medicines for Astragali Radix and Angelica sinensis Radix on myocardial infarction injury.
Pharm Biol. 2020 Dec; 58(1):165-175.PB

Abstract

Context:

Astragali Radix (AR) and Angelica sinensis Radix (ASR) combinations are used to treat cardiovascular disorders.

Objectives:

This study investigates the protective effects of different compatibility proportions of AR and ASR on cardiac dysfunction in a C57BL/6 mouse model of myocardial infarction (MI).Materials and methods: MI mice were induced by ligation of the left coronary artery and divided into six groups: sham, vehicle, 10 mg/kg/d simvastatin and combinations of AR and ASR at different ratios, including 1:1 (AR 2.5 g/kg + ASR 2.5 g/kg), 3:1 (AR 3.75 g/kg + ASR 1.25 g/kg) and 5:1 (AR 4.17 g/kg + ASR 0.83 g/kg). Both AR-ASR combinations and simvastatin were dissolved in saline solution and given daily by gavage. The left ventricle function, infarct size, heart tissue injury, apoptosis of cardiomyocytes, leukocyte infiltrates, capillary density and expression of cleaved caspase-3, cleaved caspase-9, Bcl-2, Bax, Bad, IL-1β, IL-6, VEGF, p-Akt and p-eNOS were analysed.

Results:

Different combinations of AR and ASR improve cardiac function and reduce infarct size (61.15% vs. 39.3%, 42.65% and 45.5%) and tissue injury through different mechanisms. When AR was combined with ASR at ratio of 1:1, the inflammation and cardiomyocyte apoptosis were suppressed (p < 0.05, p < 0.01). The combination ratio of 3:1 exerted effect in promoting angiogensis (p < 0.05). In the combination of AR and ASR at 5:1 ratio, angiogenesis was significantly improved (p < 0.01) and the apoptosis was inhibited (p < 0.05).

Conclusions:

Our results reflect the regulation of multiple targets and links in herb pairs and provide an important basis for the use of AR and ASR combinations in the treatment of MI.

Authors+Show Affiliations

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Shandong Danhong Pharmaceutical Co., Ltd., Heze, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, China.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, China. School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32608342

Citation

Chen, Lu, et al. "The Protective Effects of Different Compatibility Proportions of the Couplet Medicines for Astragali Radix and Angelica Sinensis Radix On Myocardial Infarction Injury." Pharmaceutical Biology, vol. 58, no. 1, 2020, pp. 165-175.
Chen L, Song M, Zhang L, et al. The protective effects of different compatibility proportions of the couplet medicines for Astragali Radix and Angelica sinensis Radix on myocardial infarction injury. Pharm Biol. 2020;58(1):165-175.
Chen, L., Song, M., Zhang, L., Li, C., Fang, Z., Coffie, J. W., Zhang, L., Ma, L., Fang, L., Wang, Q., Yang, W., Li, F., Gao, X., & Wang, H. (2020). The protective effects of different compatibility proportions of the couplet medicines for Astragali Radix and Angelica sinensis Radix on myocardial infarction injury. Pharmaceutical Biology, 58(1), 165-175. https://doi.org/10.1080/13880209.2020.1725581
Chen L, et al. The Protective Effects of Different Compatibility Proportions of the Couplet Medicines for Astragali Radix and Angelica Sinensis Radix On Myocardial Infarction Injury. Pharm Biol. 2020;58(1):165-175. PubMed PMID: 32608342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The protective effects of different compatibility proportions of the couplet medicines for Astragali Radix and Angelica sinensis Radix on myocardial infarction injury. AU - Chen,Lu, AU - Song,Min, AU - Zhang,Lusha, AU - Li,Chunxiao, AU - Fang,Zhirui, AU - Coffie,Joel Wake, AU - Zhang,Liyuan, AU - Ma,Lulu, AU - Fang,Leyu, AU - Wang,Qianyi, AU - Yang,Wenjie, AU - Li,Fanggang, AU - Gao,Xiumei, AU - Wang,Hong, PY - 2020/7/2/entrez PY - 2020/7/2/pubmed PY - 2020/7/2/medline KW - Apoptosis KW - angiogenesis KW - inflammation SP - 165 EP - 175 JF - Pharmaceutical biology JO - Pharm Biol VL - 58 IS - 1 N2 - Context: Astragali Radix (AR) and Angelica sinensis Radix (ASR) combinations are used to treat cardiovascular disorders.Objectives: This study investigates the protective effects of different compatibility proportions of AR and ASR on cardiac dysfunction in a C57BL/6 mouse model of myocardial infarction (MI).Materials and methods: MI mice were induced by ligation of the left coronary artery and divided into six groups: sham, vehicle, 10 mg/kg/d simvastatin and combinations of AR and ASR at different ratios, including 1:1 (AR 2.5 g/kg + ASR 2.5 g/kg), 3:1 (AR 3.75 g/kg + ASR 1.25 g/kg) and 5:1 (AR 4.17 g/kg + ASR 0.83 g/kg). Both AR-ASR combinations and simvastatin were dissolved in saline solution and given daily by gavage. The left ventricle function, infarct size, heart tissue injury, apoptosis of cardiomyocytes, leukocyte infiltrates, capillary density and expression of cleaved caspase-3, cleaved caspase-9, Bcl-2, Bax, Bad, IL-1β, IL-6, VEGF, p-Akt and p-eNOS were analysed.Results: Different combinations of AR and ASR improve cardiac function and reduce infarct size (61.15% vs. 39.3%, 42.65% and 45.5%) and tissue injury through different mechanisms. When AR was combined with ASR at ratio of 1:1, the inflammation and cardiomyocyte apoptosis were suppressed (p < 0.05, p < 0.01). The combination ratio of 3:1 exerted effect in promoting angiogensis (p < 0.05). In the combination of AR and ASR at 5:1 ratio, angiogenesis was significantly improved (p < 0.01) and the apoptosis was inhibited (p < 0.05).Conclusions: Our results reflect the regulation of multiple targets and links in herb pairs and provide an important basis for the use of AR and ASR combinations in the treatment of MI. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/32608342/The_protective_effects_of_different_compatibility_proportions_of_the_couplet_medicines_for_Astragali_Radix_and_Angelica_sinensis_Radix_on_myocardial_infarction_injury. L2 - https://www.tandfonline.com/doi/full/10.1080/13880209.2020.1725581 DB - PRIME DP - Unbound Medicine ER -