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Prognostic importance of RUNX1 expression for head and neck adenoid cystic carcinoma.
Oral Dis. 2020 Jul 01 [Online ahead of print]OD

Abstract

OBJECTIVE

In the present study, we aimed to investigate the prognostic value of RUNX1 expression in 76 patients with adenoid cystic carcinoma (ACC).

MATERIALS AND METHODS

All cases were arranged in tissue microarray blocks and submitted to immunohistochemistry against RUNX1. These results were statistically correlated with clinicopathologic features, including age, gender, tumour site, tumour size, lymph node status, AJCC clinical stage, distant metastasis, treatment, recurrences, follow-up, histologic pattern, vascular and neural invasion, all of which obtained from patient's medical records.

RESULTS

RUNX1 was expressed in the nuclei of tumour cells, with a mean of 18.1% of positivity. Nuclear RUNX1 expression was significantly associated with AJCC clinical stage (p < .0001), solid histologic pattern (p < .0001), vascular invasion (p < .0001) and presence of local recurrence (p < .0001). Using univariate and multivariate analyses, RUNX1 nuclear expression was significantly associated with a lower disease-free survival (p < .0001 and p = .028, respectively) and disease-specific survival (p < .0001 and p = .018, respectively) rates.

CONCLUSION

In summary, RUNX1 nuclear expression may represent an indicator of unfavourable outcome for patients affected by head and neck ACC.

Authors+Show Affiliations

Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. Private Pathology Service, Natal, Rio Grande do Norte, Brazil.Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.Private Pathology Service, Natal, Rio Grande do Norte, Brazil.Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32609408

Citation

Soares, Ciro Dantas, et al. "Prognostic Importance of RUNX1 Expression for Head and Neck Adenoid Cystic Carcinoma." Oral Diseases, 2020.
Soares CD, de Cáceres CVBL, Rodrigues-Fernandes CI, et al. Prognostic importance of RUNX1 expression for head and neck adenoid cystic carcinoma. Oral Dis. 2020.
Soares, C. D., de Cáceres, C. V. B. L., Rodrigues-Fernandes, C. I., de Lima Morais, T. M., de Almeida, O. P., de Carvalho, M. G. F., & Fonseca, F. P. (2020). Prognostic importance of RUNX1 expression for head and neck adenoid cystic carcinoma. Oral Diseases. https://doi.org/10.1111/odi.13522
Soares CD, et al. Prognostic Importance of RUNX1 Expression for Head and Neck Adenoid Cystic Carcinoma. Oral Dis. 2020 Jul 1; PubMed PMID: 32609408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic importance of RUNX1 expression for head and neck adenoid cystic carcinoma. AU - Soares,Ciro Dantas, AU - de Cáceres,Cinthia Veronica Bardález López, AU - Rodrigues-Fernandes,Carla Isabelly, AU - de Lima Morais,Thayná Melo, AU - de Almeida,Oslei Paes, AU - de Carvalho,Maria Goretti Freire, AU - Fonseca,Felipe Paiva, Y1 - 2020/07/01/ PY - 2020/02/28/received PY - 2020/06/12/revised PY - 2020/06/18/accepted PY - 2020/7/2/pubmed PY - 2020/7/2/medline PY - 2020/7/2/entrez KW - RUNX1 KW - adenoid cystic carcinoma KW - prognosis KW - salivary gland JF - Oral diseases JO - Oral Dis N2 - OBJECTIVE: In the present study, we aimed to investigate the prognostic value of RUNX1 expression in 76 patients with adenoid cystic carcinoma (ACC). MATERIALS AND METHODS: All cases were arranged in tissue microarray blocks and submitted to immunohistochemistry against RUNX1. These results were statistically correlated with clinicopathologic features, including age, gender, tumour site, tumour size, lymph node status, AJCC clinical stage, distant metastasis, treatment, recurrences, follow-up, histologic pattern, vascular and neural invasion, all of which obtained from patient's medical records. RESULTS: RUNX1 was expressed in the nuclei of tumour cells, with a mean of 18.1% of positivity. Nuclear RUNX1 expression was significantly associated with AJCC clinical stage (p < .0001), solid histologic pattern (p < .0001), vascular invasion (p < .0001) and presence of local recurrence (p < .0001). Using univariate and multivariate analyses, RUNX1 nuclear expression was significantly associated with a lower disease-free survival (p < .0001 and p = .028, respectively) and disease-specific survival (p < .0001 and p = .018, respectively) rates. CONCLUSION: In summary, RUNX1 nuclear expression may represent an indicator of unfavourable outcome for patients affected by head and neck ACC. SN - 1601-0825 UR - https://www.unboundmedicine.com/medline/citation/32609408/Prognostic_importance_of_RUNX1_expression_for_head_and_neck_adenoid_cystic_carcinoma L2 - https://doi.org/10.1111/odi.13522 DB - PRIME DP - Unbound Medicine ER -
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