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Age-dependent Differences in T Cell Responses to Influenza A Virus.
Am J Respir Cell Mol Biol. 2020 Jul 01 [Online ahead of print]AJ

Abstract

Respiratory infections from influenza A virus cause substantial morbidity and mortality in children relative to adults. T cells play a critical role in the host response to influenza A virus by supporting the innate and humoral responses, mediating cytotoxic activity, and promoting recovery. There are age-dependent differences in the number, subsets, and localization of T cells, which impact the host response to pathogens. In this article, we first review how T cells recognize influenza A virus and examine differences in the resting T cell populations between juveniles and adults. Next, we describe how the juvenile CD4+, CD8+, and regulatory T cell responses compare to those in adults and discuss the potential physiologic and clinical consequences of the differences. Finally, we explore the roles of two unconventional T cell types in the juvenile response to influenza, natural killer T cells and gamma-delta T cells. A clear understanding of age-dependent differences in the T cell response is essential to developing therapies to prevent or reverse the deleterious effects of influenza A virus in children.

Authors+Show Affiliations

Ann and Robert H Lurie Children's Hospital of Chicago, 2429, Chicago, Illinois, United States. Northwestern University Feinberg School of Medicine, 12244, Division of Critical Care Medicine, Department of Pediatrics, Chicago, Illinois, United States; aprigge@luriechildrens.org.Northwestern University Feinberg School of Medicine, 12244, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Chicago, Illinois, United States.Northwestern University Feinberg School of Medicine, 12244, Division of Critical Care Medicine, Department of Pediatrics, Chicago, Illinois, United States. Ann and Robert H Lurie Children's Hospital of Chicago, 2429, Chicago, Illinois, United States.Northwestern University Feinberg School of Medicine, 12244, Medicine and Biochemistry & Molecular Genetics, Chicago, Illinois, United States. Northwestern University Feinberg School of Medicine, 12244, Simpson Querrey Center for Epigenetics, Chicago, Illinois, United States.Northwestern University Feinberg School of Medicine, 12244, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Chicago, Illinois, United States. Northwestern University Feinberg School of Medicine, 12244, Simpson Querrey Center for Epigenetics, Chicago, Illinois, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32609537

Citation

Prigge, Andrew D., et al. "Age-dependent Differences in T Cell Responses to Influenza a Virus." American Journal of Respiratory Cell and Molecular Biology, 2020.
Prigge AD, Ma R, Coates BM, et al. Age-dependent Differences in T Cell Responses to Influenza A Virus. Am J Respir Cell Mol Biol. 2020.
Prigge, A. D., Ma, R., Coates, B. M., Singer, B. D., & Ridge, K. M. (2020). Age-dependent Differences in T Cell Responses to Influenza A Virus. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/rcmb.2020-0169TR
Prigge AD, et al. Age-dependent Differences in T Cell Responses to Influenza a Virus. Am J Respir Cell Mol Biol. 2020 Jul 1; PubMed PMID: 32609537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-dependent Differences in T Cell Responses to Influenza A Virus. AU - Prigge,Andrew D, AU - Ma,Ruihua, AU - Coates,Bria M, AU - Singer,Benjamin D, AU - Ridge,Karen M, Y1 - 2020/07/01/ PY - 2020/7/2/entrez PY - 2020/7/2/pubmed PY - 2020/7/2/medline KW - Age-dependent KW - Influenza KW - Juvenile KW - T Cell KW - Viral pneumonia JF - American journal of respiratory cell and molecular biology JO - Am. J. Respir. Cell Mol. Biol. N2 - Respiratory infections from influenza A virus cause substantial morbidity and mortality in children relative to adults. T cells play a critical role in the host response to influenza A virus by supporting the innate and humoral responses, mediating cytotoxic activity, and promoting recovery. There are age-dependent differences in the number, subsets, and localization of T cells, which impact the host response to pathogens. In this article, we first review how T cells recognize influenza A virus and examine differences in the resting T cell populations between juveniles and adults. Next, we describe how the juvenile CD4+, CD8+, and regulatory T cell responses compare to those in adults and discuss the potential physiologic and clinical consequences of the differences. Finally, we explore the roles of two unconventional T cell types in the juvenile response to influenza, natural killer T cells and gamma-delta T cells. A clear understanding of age-dependent differences in the T cell response is essential to developing therapies to prevent or reverse the deleterious effects of influenza A virus in children. SN - 1535-4989 UR - https://www.unboundmedicine.com/medline/citation/32609537/Age-dependent_Differences_in_T_Cell_Responses_to_Influenza_A_Virus L2 - https://www.atsjournals.org/doi/10.1165/rcmb.2020-0169TR?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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