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Cytokine Storms: Understanding COVID-19.
Immunity. 2020 07 14; 53(1):19-25.I

Abstract

The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in "ideal" responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes.

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Publisher Full Text
ncbi.nlm.nih.gov
linkinghub.elsevier.com
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Aggregator Full Text

Authors+Show Affiliations

Mangalmurti N
Perelman School of Medicine, University of Pennsylvania, Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA 19104, USA.
Hunter CA
School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA. Electronic address: chunter@vet.upenn.edu.

MeSH

BetacoronavirusCOVID-19Coronavirus InfectionsCytokine Release SyndromeCytokinesHumansInflammationPandemicsPneumonia, ViralSARS-CoV-2

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32610079

Clinical Trial Links

Lung Injury (Pulmonary Edema) in COVID-19: Treatment With Furosemide and Negative Fluid Balance (NEGBAL)

Citation

Mangalmurti, Nilam, and Christopher A. Hunter. "Cytokine Storms: Understanding COVID-19." Immunity, vol. 53, no. 1, 2020, pp. 19-25.
Mangalmurti N, Hunter CA. Cytokine Storms: Understanding COVID-19. Immunity. 2020;53(1):19-25.
Mangalmurti, N., & Hunter, C. A. (2020). Cytokine Storms: Understanding COVID-19. Immunity, 53(1), 19-25. https://doi.org/10.1016/j.immuni.2020.06.017
Mangalmurti N, Hunter CA. Cytokine Storms: Understanding COVID-19. Immunity. 2020 07 14;53(1):19-25. PubMed PMID: 32610079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytokine Storms: Understanding COVID-19. AU - Mangalmurti,Nilam, AU - Hunter,Christopher A, Y1 - 2020/06/28/ PY - 2020/7/2/pubmed PY - 2020/7/24/medline PY - 2020/7/2/entrez SP - 19 EP - 25 JF - Immunity JO - Immunity VL - 53 IS - 1 N2 - The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in "ideal" responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes. SN - 1097-4180 UR - https://www.unboundmedicine.com/medline/citation/32610079/Cytokine_Storms:_Understanding_COVID_19_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7613(20)30272-7 DB - PRIME DP - Unbound Medicine ER -