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Visual Experience Influences Dendritic Orientation but Is Not Required for Asymmetric Wiring of the Retinal Direction Selective Circuit.
Cell Rep. 2020 Jun 30; 31(13):107844.CR

Abstract

Changes in dendritic morphology in response to activity have long been thought to be a critical component of how neural circuits develop to properly encode sensory information. Ventral-preferring direction-selective ganglion cells (vDSGCs) have asymmetric dendrites oriented along their preferred direction, and this has been hypothesized to play a critical role in their tuning. Here we report the surprising result that visual experience is critical for the alignment of vDSGC dendrites to their preferred direction. Interestingly, vDSGCs in dark-reared mice lose their inhibition-independent dendritic contribution to direction-selective tuning while maintaining asymmetric inhibitory input. These data indicate that different mechanisms of a cell's computational abilities can be constructed over development through divergent mechanisms.

Authors+Show Affiliations

Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: mfeller@berkeley.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32610144

Citation

El-Quessny, Malak, et al. "Visual Experience Influences Dendritic Orientation but Is Not Required for Asymmetric Wiring of the Retinal Direction Selective Circuit." Cell Reports, vol. 31, no. 13, 2020, p. 107844.
El-Quessny M, Maanum K, Feller MB. Visual Experience Influences Dendritic Orientation but Is Not Required for Asymmetric Wiring of the Retinal Direction Selective Circuit. Cell Rep. 2020;31(13):107844.
El-Quessny, M., Maanum, K., & Feller, M. B. (2020). Visual Experience Influences Dendritic Orientation but Is Not Required for Asymmetric Wiring of the Retinal Direction Selective Circuit. Cell Reports, 31(13), 107844. https://doi.org/10.1016/j.celrep.2020.107844
El-Quessny M, Maanum K, Feller MB. Visual Experience Influences Dendritic Orientation but Is Not Required for Asymmetric Wiring of the Retinal Direction Selective Circuit. Cell Rep. 2020 Jun 30;31(13):107844. PubMed PMID: 32610144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visual Experience Influences Dendritic Orientation but Is Not Required for Asymmetric Wiring of the Retinal Direction Selective Circuit. AU - El-Quessny,Malak, AU - Maanum,Kayla, AU - Feller,Marla B, PY - 2019/12/03/received PY - 2020/05/22/revised PY - 2020/06/10/accepted PY - 2020/7/2/entrez PY - 2020/7/2/pubmed PY - 2020/7/2/medline KW - retina, asymmetric, dendrite, development, morphology, visual experience, direction selective, circuit computation, asymmetric inhibition SP - 107844 EP - 107844 JF - Cell reports JO - Cell Rep VL - 31 IS - 13 N2 - Changes in dendritic morphology in response to activity have long been thought to be a critical component of how neural circuits develop to properly encode sensory information. Ventral-preferring direction-selective ganglion cells (vDSGCs) have asymmetric dendrites oriented along their preferred direction, and this has been hypothesized to play a critical role in their tuning. Here we report the surprising result that visual experience is critical for the alignment of vDSGC dendrites to their preferred direction. Interestingly, vDSGCs in dark-reared mice lose their inhibition-independent dendritic contribution to direction-selective tuning while maintaining asymmetric inhibitory input. These data indicate that different mechanisms of a cell's computational abilities can be constructed over development through divergent mechanisms. SN - 2211-1247 UR - https://www.unboundmedicine.com/medline/citation/32610144/Visual_Experience_Influences_Dendritic_Orientation_but_Is_Not_Required_for_Asymmetric_Wiring_of_the_Retinal_Direction_Selective_Circuit L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(20)30825-1 DB - PRIME DP - Unbound Medicine ER -
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