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Inhibitory Activities of Polyphenolic Extracts of Bangladeshi Vegetables against α-Amylase, α-Glucosidase, Pancreatic Lipase, Renin, and Angiotensin-Converting Enzyme.
Foods. 2020 Jun 29; 9(7)F

Abstract

The aim of the study was to determine the in vitro enzyme inhibition activities of aqueous polyphenolic extracts of nine popular Bangladeshi vegetables, namely ash gourd, bitter gourd, brinjal, Indian spinach, kangkong, okra, ridge gourd, snake gourd, and stem amaranth. Polyphenolic glycosides were the major compounds present in the extracts. Inhibition of α-amylase (up to 100% at 1 mg/mL) was stronger than α-glucosidase inhibition (up to 70.78% at 10 mg/mL). The Indian spinach extract was the strongest inhibitor of pancreatic lipase activity (IC50 = 276.77 µg/mL), which was significantly better than that of orlistat (381.16 µg/mL), a drug. Ash gourd (76.51%), brinjal (72.48%), and snake gourd (66.82%) extracts were the most effective inhibitors of angiotensin-converting enzyme (ACE), an enzyme whose excessive activities have been associated with hypertension. Brinjal also had a significantly higher renin-inhibitory activity than the other vegetable extracts. We conclude that the vegetable extracts may have the ability to reduce enzyme activities that have been associated with hyperglycemia, hyperlipidemia, and hypertension.

Authors+Show Affiliations

Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.Institute of Nutrition and Food Sciences, University of Dhaka, Nilkhet Rd, Dhaka 1000, Bangladesh.Natural Resources Management Division, Bangladesh Agricultural Research Council, Dhaka 1215, Bangladesh.Natural Resources Institute, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada. The Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32610462

Citation

Sultana, Razia, et al. "Inhibitory Activities of Polyphenolic Extracts of Bangladeshi Vegetables Against α-Amylase, α-Glucosidase, Pancreatic Lipase, Renin, and Angiotensin-Converting Enzyme." Foods (Basel, Switzerland), vol. 9, no. 7, 2020.
Sultana R, Alashi AM, Islam K, et al. Inhibitory Activities of Polyphenolic Extracts of Bangladeshi Vegetables against α-Amylase, α-Glucosidase, Pancreatic Lipase, Renin, and Angiotensin-Converting Enzyme. Foods. 2020;9(7).
Sultana, R., Alashi, A. M., Islam, K., Saifullah, M., Haque, C. E., & Aluko, R. E. (2020). Inhibitory Activities of Polyphenolic Extracts of Bangladeshi Vegetables against α-Amylase, α-Glucosidase, Pancreatic Lipase, Renin, and Angiotensin-Converting Enzyme. Foods (Basel, Switzerland), 9(7). https://doi.org/10.3390/foods9070844
Sultana R, et al. Inhibitory Activities of Polyphenolic Extracts of Bangladeshi Vegetables Against α-Amylase, α-Glucosidase, Pancreatic Lipase, Renin, and Angiotensin-Converting Enzyme. Foods. 2020 Jun 29;9(7) PubMed PMID: 32610462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory Activities of Polyphenolic Extracts of Bangladeshi Vegetables against α-Amylase, α-Glucosidase, Pancreatic Lipase, Renin, and Angiotensin-Converting Enzyme. AU - Sultana,Razia, AU - Alashi,Adeola M, AU - Islam,Khaleda, AU - Saifullah,Md, AU - Haque,C Emdad, AU - Aluko,Rotimi E, Y1 - 2020/06/29/ PY - 2020/05/19/received PY - 2020/06/06/revised PY - 2020/06/10/accepted PY - 2020/7/3/entrez KW - Bangladesh KW - amylase KW - angiotensin-converting enzyme KW - glucosidase KW - lipase KW - mass spectrometry KW - polyphenols KW - renin KW - vegetables JF - Foods (Basel, Switzerland) JO - Foods VL - 9 IS - 7 N2 - The aim of the study was to determine the in vitro enzyme inhibition activities of aqueous polyphenolic extracts of nine popular Bangladeshi vegetables, namely ash gourd, bitter gourd, brinjal, Indian spinach, kangkong, okra, ridge gourd, snake gourd, and stem amaranth. Polyphenolic glycosides were the major compounds present in the extracts. Inhibition of α-amylase (up to 100% at 1 mg/mL) was stronger than α-glucosidase inhibition (up to 70.78% at 10 mg/mL). The Indian spinach extract was the strongest inhibitor of pancreatic lipase activity (IC50 = 276.77 µg/mL), which was significantly better than that of orlistat (381.16 µg/mL), a drug. Ash gourd (76.51%), brinjal (72.48%), and snake gourd (66.82%) extracts were the most effective inhibitors of angiotensin-converting enzyme (ACE), an enzyme whose excessive activities have been associated with hypertension. Brinjal also had a significantly higher renin-inhibitory activity than the other vegetable extracts. We conclude that the vegetable extracts may have the ability to reduce enzyme activities that have been associated with hyperglycemia, hyperlipidemia, and hypertension. SN - 2304-8158 UR - https://www.unboundmedicine.com/medline/citation/32610462/Inhibitory_Activities_of_Polyphenolic_Extracts_of_Bangladeshi_Vegetables_against_α-Amylase,_α-Glucosidase,_Pancreatic_Lipase,_Renin,_and_Angiotensin-Converting_Enzyme DB - PRIME DP - Unbound Medicine ER -
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