Tags

Type your tag names separated by a space and hit enter

Comparison of non-schistosomal colorectal cancer and schistosomal colorectal cancer.
World J Surg Oncol. 2020 Jul 01; 18(1):149.WJ

Abstract

AIM

The purpose of this study was to compare clinicopathological features of patients with non-schistosomal and schistosomal colorectal cancer to explore the effect of schistosomiasis on colorectal cancer (CRC) patients' clinical outcomes.

METHODS

Three hundred fifty-one cases of CRC were retrospectively analyzed in this study. Survival curves were constructed by using the Kaplan-Meier (K-M) method. Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables.

RESULTS

Colorectal cancer patients with schistosomiasis (CRC-S) were significantly older (P < 0.001) than the patients without schistosomiasis (CRC-NS). However, there were no significant differences between CRC-S and CRC-NS patients in other clinicopathological features. Schistosomiasis was associated with adverse overall survival (OS) upon K-M analysis (P = 0.0277). By univariate and multivariate analysis, gender (P = 0.003), TNM stage (P < 0.001), schistosomiasis (P = 0.025), lymphovascular invasion (P = 0.030), and lymph nodes positive for CRC (P < 0.001) were all independent predictors in the whole cohort. When patients were stratified according to clinical stage and lymph node metastasis state, schistosomiasis was also an independent predictor in patients with stage III-IV tumors and in patients with lymph node metastasis, but not in patients with stage I-II tumors and in patients without lymph node metastasis.

CONCLUSION

Schistosomiasis was significantly correlated with OS, and it was an independent prognostic factor for OS in the whole cohort. When patients were stratified according to clinical stage and lymph node metastasis state, schistosomiasis was still an independently unfavorable prognosis factor for OS in patients with stage III-IV tumors or patients with lymph node metastasis.

Authors+Show Affiliations

Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China.Department of Pathology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital, No.1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, People's Republic of China. judy1108@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32611359

Citation

Wang, Weixia, et al. "Comparison of Non-schistosomal Colorectal Cancer and Schistosomal Colorectal Cancer." World Journal of Surgical Oncology, vol. 18, no. 1, 2020, p. 149.
Wang W, Lu K, Wang L, et al. Comparison of non-schistosomal colorectal cancer and schistosomal colorectal cancer. World J Surg Oncol. 2020;18(1):149.
Wang, W., Lu, K., Wang, L., Jing, H., Pan, W., Huang, S., Xu, Y., Bu, D., Cheng, M., Liu, J., Liu, J., Shen, W., Zhang, Y., Yao, J., & Zhu, T. (2020). Comparison of non-schistosomal colorectal cancer and schistosomal colorectal cancer. World Journal of Surgical Oncology, 18(1), 149. https://doi.org/10.1186/s12957-020-01925-5
Wang W, et al. Comparison of Non-schistosomal Colorectal Cancer and Schistosomal Colorectal Cancer. World J Surg Oncol. 2020 Jul 1;18(1):149. PubMed PMID: 32611359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of non-schistosomal colorectal cancer and schistosomal colorectal cancer. AU - Wang,Weixia, AU - Lu,Kui, AU - Wang,Limei, AU - Jing,Hongyan, AU - Pan,Weiyu, AU - Huang,Sinian, AU - Xu,Yanchao, AU - Bu,Dacheng, AU - Cheng,Meihong, AU - Liu,Jing, AU - Liu,Jican, AU - Shen,Weidong, AU - Zhang,Yingyi, AU - Yao,Junxia, AU - Zhu,Ting, Y1 - 2020/07/01/ PY - 2020/02/26/received PY - 2020/06/18/accepted PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline KW - Colorectal cancer KW - Overall survival KW - Prognosis KW - Schistosomiasis SP - 149 EP - 149 JF - World journal of surgical oncology JO - World J Surg Oncol VL - 18 IS - 1 N2 - AIM: The purpose of this study was to compare clinicopathological features of patients with non-schistosomal and schistosomal colorectal cancer to explore the effect of schistosomiasis on colorectal cancer (CRC) patients' clinical outcomes. METHODS: Three hundred fifty-one cases of CRC were retrospectively analyzed in this study. Survival curves were constructed by using the Kaplan-Meier (K-M) method. Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables. RESULTS: Colorectal cancer patients with schistosomiasis (CRC-S) were significantly older (P < 0.001) than the patients without schistosomiasis (CRC-NS). However, there were no significant differences between CRC-S and CRC-NS patients in other clinicopathological features. Schistosomiasis was associated with adverse overall survival (OS) upon K-M analysis (P = 0.0277). By univariate and multivariate analysis, gender (P = 0.003), TNM stage (P < 0.001), schistosomiasis (P = 0.025), lymphovascular invasion (P = 0.030), and lymph nodes positive for CRC (P < 0.001) were all independent predictors in the whole cohort. When patients were stratified according to clinical stage and lymph node metastasis state, schistosomiasis was also an independent predictor in patients with stage III-IV tumors and in patients with lymph node metastasis, but not in patients with stage I-II tumors and in patients without lymph node metastasis. CONCLUSION: Schistosomiasis was significantly correlated with OS, and it was an independent prognostic factor for OS in the whole cohort. When patients were stratified according to clinical stage and lymph node metastasis state, schistosomiasis was still an independently unfavorable prognosis factor for OS in patients with stage III-IV tumors or patients with lymph node metastasis. SN - 1477-7819 UR - https://www.unboundmedicine.com/medline/citation/32611359/Comparison_of_non-schistosomal_colorectal_cancer_and_schistosomal_colorectal_cancer L2 - https://wjso.biomedcentral.com/articles/10.1186/s12957-020-01925-5 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.