Tags

Type your tag names separated by a space and hit enter

Biomechanical properties of common carotid arteries assessed by circumferential two-dimensional strain and beta stiffness index in patients with ankylosing spondylitis.
J Rheumatol. 2020 Jul 01 [Online ahead of print]JR

Abstract

OBJECTIVE

Ankylosing spondylitis (AS) is associated with an elevated risk of cardiovascular disease (CVD) related to atherosclerosis, preceded by arterial stiffness. We aimed to examine common carotid artery (CCA) biomechanical properties using ultrasound to calculate β stiffness index (indicating arterial stiffness) and, a more recently developed technique, two-dimensional (2D) speckle tracking strain (indicating arterial motion and deformation, strain) to 1) compare with age- and sex-matched controls and to 2) analyze relationships between strain and stiffness with disease characteristics and traditional risk factors for CVD in AS patients.

METHODS

In this cross-sectional study, a cohort of 149 patients with AS, mean age 55.3±11.2 years, 102(68.5%) men, 146 (98%) HLA-B27 positive, were examined. Bilateral CCAs were examined for circumferential 2D strain and β stiffness index. A subgroup of 46 patients were compared with 46 age- and sex-matched controls, both groups without hypertensive disease, diabetes, myocardial infarction or stroke.

RESULTS

Mean bilateral circumferential 2D strain was lower in AS patients compared with controls, 7.9±2.6% vs 10.3±1.9%, p<0.001 whereas mean bilateral β stiffness index was higher, 13.1±1.6mmHg/mm vs 12.3±1.3mmHg/mm, p=0.018. In multivariable linear regression analyses strain was associated with age, erythrocyte sedimentation rate, history of anterior uveitis and treatment with csDMARD and/or bDMARD (R2 0.33), while stiffness was associated with age (R2 0.19).

CONCLUSION

Both CCA circumferential 2D strain and β stiffness index differed between AS patients and controls. Strain was associated with AS-related factors and age while stiffness with age, suggesting that the obtained results reflect different pathogenic vascular processes.

Authors+Show Affiliations

From the Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital,Department of Rheumatology, Gothenburg, Sweden, Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden and Faculty of Medicine, Lund University, Lund, Sweden, Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. This study was supported by grants from The Swedish Research Council, Västerbotten's Association Against Rheumatism, The Swedish Association Against Rheumatism, the County of Västerbotten (agreement concerning research and education of doctors), King Gustaf Vth 80-year Foundation, The Norrland's Heart Foundation, and Mats Kleberg's Foundation. Address correspondence to Helena Forsblad-d'Elia, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, SE-901 87 Umeå, Sweden E-mail: helena.forsblad.delia@umu.se.From the Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital,Department of Rheumatology, Gothenburg, Sweden, Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden and Faculty of Medicine, Lund University, Lund, Sweden, Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. This study was supported by grants from The Swedish Research Council, Västerbotten's Association Against Rheumatism, The Swedish Association Against Rheumatism, the County of Västerbotten (agreement concerning research and education of doctors), King Gustaf Vth 80-year Foundation, The Norrland's Heart Foundation, and Mats Kleberg's Foundation. Address correspondence to Helena Forsblad-d'Elia, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, SE-901 87 Umeå, Sweden E-mail: helena.forsblad.delia@umu.se.From the Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital,Department of Rheumatology, Gothenburg, Sweden, Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden and Faculty of Medicine, Lund University, Lund, Sweden, Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. This study was supported by grants from The Swedish Research Council, Västerbotten's Association Against Rheumatism, The Swedish Association Against Rheumatism, the County of Västerbotten (agreement concerning research and education of doctors), King Gustaf Vth 80-year Foundation, The Norrland's Heart Foundation, and Mats Kleberg's Foundation. Address correspondence to Helena Forsblad-d'Elia, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, SE-901 87 Umeå, Sweden E-mail: helena.forsblad.delia@umu.se.From the Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital,Department of Rheumatology, Gothenburg, Sweden, Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden and Faculty of Medicine, Lund University, Lund, Sweden, Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. This study was supported by grants from The Swedish Research Council, Västerbotten's Association Against Rheumatism, The Swedish Association Against Rheumatism, the County of Västerbotten (agreement concerning research and education of doctors), King Gustaf Vth 80-year Foundation, The Norrland's Heart Foundation, and Mats Kleberg's Foundation. Address correspondence to Helena Forsblad-d'Elia, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, SE-901 87 Umeå, Sweden E-mail: helena.forsblad.delia@umu.se.From the Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital,Department of Rheumatology, Gothenburg, Sweden, Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden and Faculty of Medicine, Lund University, Lund, Sweden, Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. This study was supported by grants from The Swedish Research Council, Västerbotten's Association Against Rheumatism, The Swedish Association Against Rheumatism, the County of Västerbotten (agreement concerning research and education of doctors), King Gustaf Vth 80-year Foundation, The Norrland's Heart Foundation, and Mats Kleberg's Foundation. Address correspondence to Helena Forsblad-d'Elia, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, SE-901 87 Umeå, Sweden E-mail: helena.forsblad.delia@umu.se.From the Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital,Department of Rheumatology, Gothenburg, Sweden, Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden and Faculty of Medicine, Lund University, Lund, Sweden, Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. This study was supported by grants from The Swedish Research Council, Västerbotten's Association Against Rheumatism, The Swedish Association Against Rheumatism, the County of Västerbotten (agreement concerning research and education of doctors), King Gustaf Vth 80-year Foundation, The Norrland's Heart Foundation, and Mats Kleberg's Foundation. Address correspondence to Helena Forsblad-d'Elia, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, SE-901 87 Umeå, Sweden E-mail: helena.forsblad.delia@umu.se.From the Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital,Department of Rheumatology, Gothenburg, Sweden, Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden and Faculty of Medicine, Lund University, Lund, Sweden, Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. This study was supported by grants from The Swedish Research Council, Västerbotten's Association Against Rheumatism, The Swedish Association Against Rheumatism, the County of Västerbotten (agreement concerning research and education of doctors), King Gustaf Vth 80-year Foundation, The Norrland's Heart Foundation, and Mats Kleberg's Foundation. Address correspondence to Helena Forsblad-d'Elia, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, SE-901 87 Umeå, Sweden E-mail: helena.forsblad.delia@umu.se.From the Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital,Department of Rheumatology, Gothenburg, Sweden, Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden and Faculty of Medicine, Lund University, Lund, Sweden, Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. This study was supported by grants from The Swedish Research Council, Västerbotten's Association Against Rheumatism, The Swedish Association Against Rheumatism, the County of Västerbotten (agreement concerning research and education of doctors), King Gustaf Vth 80-year Foundation, The Norrland's Heart Foundation, and Mats Kleberg's Foundation. Address correspondence to Helena Forsblad-d'Elia, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, SE-901 87 Umeå, Sweden E-mail: helena.forsblad.delia@umu.se.From the Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital,Department of Rheumatology, Gothenburg, Sweden, Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden and Faculty of Medicine, Lund University, Lund, Sweden, Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. This study was supported by grants from The Swedish Research Council, Västerbotten's Association Against Rheumatism, The Swedish Association Against Rheumatism, the County of Västerbotten (agreement concerning research and education of doctors), King Gustaf Vth 80-year Foundation, The Norrland's Heart Foundation, and Mats Kleberg's Foundation. Address correspondence to Helena Forsblad-d'Elia, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, SE-901 87 Umeå, Sweden E-mail: helena.forsblad.delia@umu.se.From the Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital,Department of Rheumatology, Gothenburg, Sweden, Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå University, Umeå, Sweden, Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden and Faculty of Medicine, Lund University, Lund, Sweden, Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. This study was supported by grants from The Swedish Research Council, Västerbotten's Association Against Rheumatism, The Swedish Association Against Rheumatism, the County of Västerbotten (agreement concerning research and education of doctors), King Gustaf Vth 80-year Foundation, The Norrland's Heart Foundation, and Mats Kleberg's Foundation. Address correspondence to Helena Forsblad-d'Elia, Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, SE-901 87 Umeå, Sweden E-mail: helena.forsblad.delia@umu.se.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32611672

Citation

Forsblad-d'Elia, Helena, et al. "Biomechanical Properties of Common Carotid Arteries Assessed By Circumferential Two-dimensional Strain and Beta Stiffness Index in Patients With Ankylosing Spondylitis." The Journal of Rheumatology, 2020.
Forsblad-d'Elia H, Law L, Bengtsson K, et al. Biomechanical properties of common carotid arteries assessed by circumferential two-dimensional strain and beta stiffness index in patients with ankylosing spondylitis. J Rheumatol. 2020.
Forsblad-d'Elia, H., Law, L., Bengtsson, K., Smeds, J., Ketonen, M., Sundström, B., Ljung, L., Geijer, M., Söderberg, S., & Lindqvist, P. (2020). Biomechanical properties of common carotid arteries assessed by circumferential two-dimensional strain and beta stiffness index in patients with ankylosing spondylitis. The Journal of Rheumatology. https://doi.org/10.3899/jrheum.200146
Forsblad-d'Elia H, et al. Biomechanical Properties of Common Carotid Arteries Assessed By Circumferential Two-dimensional Strain and Beta Stiffness Index in Patients With Ankylosing Spondylitis. J Rheumatol. 2020 Jul 1; PubMed PMID: 32611672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomechanical properties of common carotid arteries assessed by circumferential two-dimensional strain and beta stiffness index in patients with ankylosing spondylitis. AU - Forsblad-d'Elia,Helena, AU - Law,Lucy, AU - Bengtsson,Karin, AU - Smeds,Johan, AU - Ketonen,Maria, AU - Sundström,Björn, AU - Ljung,Lotta, AU - Geijer,Mats, AU - Söderberg,Stefan, AU - Lindqvist,Per, Y1 - 2020/07/01/ PY - 2020/7/3/entrez JF - The Journal of rheumatology JO - J. Rheumatol. N2 - OBJECTIVE: Ankylosing spondylitis (AS) is associated with an elevated risk of cardiovascular disease (CVD) related to atherosclerosis, preceded by arterial stiffness. We aimed to examine common carotid artery (CCA) biomechanical properties using ultrasound to calculate β stiffness index (indicating arterial stiffness) and, a more recently developed technique, two-dimensional (2D) speckle tracking strain (indicating arterial motion and deformation, strain) to 1) compare with age- and sex-matched controls and to 2) analyze relationships between strain and stiffness with disease characteristics and traditional risk factors for CVD in AS patients. METHODS: In this cross-sectional study, a cohort of 149 patients with AS, mean age 55.3±11.2 years, 102(68.5%) men, 146 (98%) HLA-B27 positive, were examined. Bilateral CCAs were examined for circumferential 2D strain and β stiffness index. A subgroup of 46 patients were compared with 46 age- and sex-matched controls, both groups without hypertensive disease, diabetes, myocardial infarction or stroke. RESULTS: Mean bilateral circumferential 2D strain was lower in AS patients compared with controls, 7.9±2.6% vs 10.3±1.9%, p<0.001 whereas mean bilateral β stiffness index was higher, 13.1±1.6mmHg/mm vs 12.3±1.3mmHg/mm, p=0.018. In multivariable linear regression analyses strain was associated with age, erythrocyte sedimentation rate, history of anterior uveitis and treatment with csDMARD and/or bDMARD (R2 0.33), while stiffness was associated with age (R2 0.19). CONCLUSION: Both CCA circumferential 2D strain and β stiffness index differed between AS patients and controls. Strain was associated with AS-related factors and age while stiffness with age, suggesting that the obtained results reflect different pathogenic vascular processes. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/32611672/Biomechanical_properties_of_common_carotid_arteries_assessed_by_circumferential_two-dimensional_strain_and_beta_stiffness_index_in_patients_with_ankylosing_spondylitis L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=32611672 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.