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Effect of laser moxibustion for knee osteoarthritis: a multi-site double-blind randomized controlled trial.
J Rheumatol. 2020 Jul 01 [Online ahead of print]JR

Abstract

OBJECTIVE

To examine the effects of laser moxibustion on pain and function in patients with knee osteoarthritis.

METHODS

A double-blind randomized clinical trial (4-week treatment, 20-week follow-up) was conducted. A total of 392 symptomatic knee osteoarthritis patients with moderate or greater clinically significant knee pain were randomly assigned to laser treatment or sham laser control group (1:1). Twelve sessions of laser moxibustion treatments or sham on the acupuncture points at the affected knee(s) were performed three times a week for 4 weeks. The primary outcome measurement was change in WOMAC pain score from baseline to week 4.

RESULTS

Among the 392 randomized participants, 364 (92.86%) completed the trial. The median WOMAC pain score significantly decreased at week 4 in the active group than in the sham group (2.1; 95% CI, 1.6 to 2.6; P < .01). At week 24, compared to the sham laser, active laser treatment resulted in significant pain reduction and function improvement (3.0; 95% CI, 2.5 to 3.6; P < 0.01, and 14.8; 95% CI, 11.9 to 17.6; P < .01, respectively). The physical component of the quality of life significantly improved in the active group than in the sham control at week 4 (3.2; 95% CI, 1.3 to 5.0; P = 0.001) up to week 24 (5.1; 95% CI, 3.3 to 7.0; P < .001). No serious adverse effects were reported.

CONCLUSION

Laser moxibustion resulted in statistically and clinically significant pain reduction and function improvement following a 4-week treatment in patients with knee osteoarthritis.

Authors+Show Affiliations

From the School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China; School of Shanghai Research Center of Acupuncture & Meridian, China; Department of Orthopedics and Traumatology department Shuguang Hospital, Shanghai, China; Department of Traditional Chinese Medicine, Shanghai Tongren Traditional Chinese Medicine Hospital, Shanghai, China; Department of Biostatistics, Bioinformatics & Biomathematics Georgetown University Medical Center, Washington, USA; Virginia University of Integrative Medicine, Fairfax, USA. Address correspondence to Xueyong Shen, MD, School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China , E-mail: sxy1@shutcm.edu.cn; Lixing Lao, PhD, Virginia University of Integrative Medicine, Fairfax, VA 22031, USA; School of Chinese Medicine, University of Hong Kong, Hong Kong, China ,E-mail: llao@vuim.edu.From the School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China; School of Shanghai Research Center of Acupuncture & Meridian, China; Department of Orthopedics and Traumatology department Shuguang Hospital, Shanghai, China; Department of Traditional Chinese Medicine, Shanghai Tongren Traditional Chinese Medicine Hospital, Shanghai, China; Department of Biostatistics, Bioinformatics & Biomathematics Georgetown University Medical Center, Washington, USA; Virginia University of Integrative Medicine, Fairfax, USA. Address correspondence to Xueyong Shen, MD, School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China , E-mail: sxy1@shutcm.edu.cn; Lixing Lao, PhD, Virginia University of Integrative Medicine, Fairfax, VA 22031, USA; School of Chinese Medicine, University of Hong Kong, Hong Kong, China ,E-mail: llao@vuim.edu.From the School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China; School of Shanghai Research Center of Acupuncture & Meridian, China; Department of Orthopedics and Traumatology department Shuguang Hospital, Shanghai, China; Department of Traditional Chinese Medicine, Shanghai Tongren Traditional Chinese Medicine Hospital, Shanghai, China; Department of Biostatistics, Bioinformatics & Biomathematics Georgetown University Medical Center, Washington, USA; Virginia University of Integrative Medicine, Fairfax, USA. Address correspondence to Xueyong Shen, MD, School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China , E-mail: sxy1@shutcm.edu.cn; Lixing Lao, PhD, Virginia University of Integrative Medicine, Fairfax, VA 22031, USA; School of Chinese Medicine, University of Hong Kong, Hong Kong, China ,E-mail: llao@vuim.edu.From the School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China; School of Shanghai Research Center of Acupuncture & Meridian, China; Department of Orthopedics and Traumatology department Shuguang Hospital, Shanghai, China; Department of Traditional Chinese Medicine, Shanghai Tongren Traditional Chinese Medicine Hospital, Shanghai, China; Department of Biostatistics, Bioinformatics & Biomathematics Georgetown University Medical Center, Washington, USA; Virginia University of Integrative Medicine, Fairfax, USA. Address correspondence to Xueyong Shen, MD, School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China , E-mail: sxy1@shutcm.edu.cn; Lixing Lao, PhD, Virginia University of Integrative Medicine, Fairfax, VA 22031, USA; School of Chinese Medicine, University of Hong Kong, Hong Kong, China ,E-mail: llao@vuim.edu.From the School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China; School of Shanghai Research Center of Acupuncture & Meridian, China; Department of Orthopedics and Traumatology department Shuguang Hospital, Shanghai, China; Department of Traditional Chinese Medicine, Shanghai Tongren Traditional Chinese Medicine Hospital, Shanghai, China; Department of Biostatistics, Bioinformatics & Biomathematics Georgetown University Medical Center, Washington, USA; Virginia University of Integrative Medicine, Fairfax, USA. Address correspondence to Xueyong Shen, MD, School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China , E-mail: sxy1@shutcm.edu.cn; Lixing Lao, PhD, Virginia University of Integrative Medicine, Fairfax, VA 22031, USA; School of Chinese Medicine, University of Hong Kong, Hong Kong, China ,E-mail: llao@vuim.edu.From the School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China; School of Shanghai Research Center of Acupuncture & Meridian, China; Department of Orthopedics and Traumatology department Shuguang Hospital, Shanghai, China; Department of Traditional Chinese Medicine, Shanghai Tongren Traditional Chinese Medicine Hospital, Shanghai, China; Department of Biostatistics, Bioinformatics & Biomathematics Georgetown University Medical Center, Washington, USA; Virginia University of Integrative Medicine, Fairfax, USA. Address correspondence to Xueyong Shen, MD, School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China , E-mail: sxy1@shutcm.edu.cn; Lixing Lao, PhD, Virginia University of Integrative Medicine, Fairfax, VA 22031, USA; School of Chinese Medicine, University of Hong Kong, Hong Kong, China ,E-mail: llao@vuim.edu.From the School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China; School of Shanghai Research Center of Acupuncture & Meridian, China; Department of Orthopedics and Traumatology department Shuguang Hospital, Shanghai, China; Department of Traditional Chinese Medicine, Shanghai Tongren Traditional Chinese Medicine Hospital, Shanghai, China; Department of Biostatistics, Bioinformatics & Biomathematics Georgetown University Medical Center, Washington, USA; Virginia University of Integrative Medicine, Fairfax, USA. Address correspondence to Xueyong Shen, MD, School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China , E-mail: sxy1@shutcm.edu.cn; Lixing Lao, PhD, Virginia University of Integrative Medicine, Fairfax, VA 22031, USA; School of Chinese Medicine, University of Hong Kong, Hong Kong, China ,E-mail: llao@vuim.edu.From the School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China; School of Shanghai Research Center of Acupuncture & Meridian, China; Department of Orthopedics and Traumatology department Shuguang Hospital, Shanghai, China; Department of Traditional Chinese Medicine, Shanghai Tongren Traditional Chinese Medicine Hospital, Shanghai, China; Department of Biostatistics, Bioinformatics & Biomathematics Georgetown University Medical Center, Washington, USA; Virginia University of Integrative Medicine, Fairfax, USA. Address correspondence to Xueyong Shen, MD, School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China , E-mail: sxy1@shutcm.edu.cn; Lixing Lao, PhD, Virginia University of Integrative Medicine, Fairfax, VA 22031, USA; School of Chinese Medicine, University of Hong Kong, Hong Kong, China ,E-mail: llao@vuim.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32611673

Citation

Zhao, Ling, et al. "Effect of Laser Moxibustion for Knee Osteoarthritis: a Multi-site Double-blind Randomized Controlled Trial." The Journal of Rheumatology, 2020.
Zhao L, Cheng K, Wu F, et al. Effect of laser moxibustion for knee osteoarthritis: a multi-site double-blind randomized controlled trial. J Rheumatol. 2020.
Zhao, L., Cheng, K., Wu, F., Du, J., Chen, Y., Tan, M. T., Lao, L., & Shen, X. (2020). Effect of laser moxibustion for knee osteoarthritis: a multi-site double-blind randomized controlled trial. The Journal of Rheumatology. https://doi.org/10.3899/jrheum.200217
Zhao L, et al. Effect of Laser Moxibustion for Knee Osteoarthritis: a Multi-site Double-blind Randomized Controlled Trial. J Rheumatol. 2020 Jul 1; PubMed PMID: 32611673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of laser moxibustion for knee osteoarthritis: a multi-site double-blind randomized controlled trial. AU - Zhao,Ling, AU - Cheng,Ke, AU - Wu,Fan, AU - Du,Jiong, AU - Chen,Yue, AU - Tan,Ming T, AU - Lao,Lixing, AU - Shen,Xueyong, Y1 - 2020/07/01/ PY - 2020/7/3/entrez KW - 10.6μm laser moxibustion KW - knee osteoarthritis KW - pain KW - traditional Chinese medicine phototherapy. JF - The Journal of rheumatology JO - J. Rheumatol. N2 - OBJECTIVE: To examine the effects of laser moxibustion on pain and function in patients with knee osteoarthritis. METHODS: A double-blind randomized clinical trial (4-week treatment, 20-week follow-up) was conducted. A total of 392 symptomatic knee osteoarthritis patients with moderate or greater clinically significant knee pain were randomly assigned to laser treatment or sham laser control group (1:1). Twelve sessions of laser moxibustion treatments or sham on the acupuncture points at the affected knee(s) were performed three times a week for 4 weeks. The primary outcome measurement was change in WOMAC pain score from baseline to week 4. RESULTS: Among the 392 randomized participants, 364 (92.86%) completed the trial. The median WOMAC pain score significantly decreased at week 4 in the active group than in the sham group (2.1; 95% CI, 1.6 to 2.6; P < .01). At week 24, compared to the sham laser, active laser treatment resulted in significant pain reduction and function improvement (3.0; 95% CI, 2.5 to 3.6; P < 0.01, and 14.8; 95% CI, 11.9 to 17.6; P < .01, respectively). The physical component of the quality of life significantly improved in the active group than in the sham control at week 4 (3.2; 95% CI, 1.3 to 5.0; P = 0.001) up to week 24 (5.1; 95% CI, 3.3 to 7.0; P < .001). No serious adverse effects were reported. CONCLUSION: Laser moxibustion resulted in statistically and clinically significant pain reduction and function improvement following a 4-week treatment in patients with knee osteoarthritis. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/32611673/Effect_of_laser_moxibustion_for_knee_osteoarthritis:_a_multi-site_double-blind_randomized_controlled_trial L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=32611673 DB - PRIME DP - Unbound Medicine ER -
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