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Newer Concepts in the Classification of Pituitary Adenomas.
Neurol India. 2020 May-Jun; 68(Supplement):S7-S12.NI

Abstract

The classification of tumors of the pituitary gland has seen several changes in recent years. The 4th edition of the World Health Organization Classification of Tumours of Endocrine Organs, published in 2017, saw the introduction of a classification based on cell lineage using immunohistochemistry for both pituitary specific hormones as well as pituitary specific transcription factors. The term "hormone-producing" was thus replaced by "-troph." The other major change was that the entity of "atypical adenoma," which was introduced in the 2004 classification, to identify tumors with a poor prognosis, was removed as it failed to identify aggressive tumors. Instead, assessment of markers of proliferation, clinical parameters, such as invasive status and histological subtypes were recommended to identify tumors with aggressive potential. The diagnostic criteria for pituitary carcinoma, however, remained unchanged and continued to be defined as a tumor of adenohypophyseal cells that metastasize craniospinally or systemically. Null cell adenomas were more clearly defined as tumors that did not show any cell-type differentiation, lacking immunoexpression of hormones as well as transcription factors. Since 2017, the classification has continued to evolve with the identification of aggressive histological variants. There is more recently a proposal to change the terminology from pituitary adenoma to pituitary neuroendocrine tumor (PitNET). This review summarizes the recent advances in the classification of pituitary adenomas.

Authors+Show Affiliations

Department of Neuropathology, Christian Medical College, Vellore, Tamil Nadu, India.Department of General Pathology, Christian Medical College, Vellore, Tamil Nadu, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32611886

Citation

Sathyakumar, Rima, and Geeta Chacko. "Newer Concepts in the Classification of Pituitary Adenomas." Neurology India, vol. 68, no. Supplement, 2020, pp. S7-S12.
Sathyakumar R, Chacko G. Newer Concepts in the Classification of Pituitary Adenomas. Neurol India. 2020;68(Supplement):S7-S12.
Sathyakumar, R., & Chacko, G. (2020). Newer Concepts in the Classification of Pituitary Adenomas. Neurology India, 68(Supplement), S7-S12. https://doi.org/10.4103/0028-3886.287667
Sathyakumar R, Chacko G. Newer Concepts in the Classification of Pituitary Adenomas. Neurol India. 2020 May-Jun;68(Supplement):S7-S12. PubMed PMID: 32611886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Newer Concepts in the Classification of Pituitary Adenomas. AU - Sathyakumar,Rima, AU - Chacko,Geeta, PY - 2020/7/3/entrez KW - PitNET KW - Pituitary adenoma KW - Transcription factors SP - S7 EP - S12 JF - Neurology India JO - Neurol India VL - 68 IS - Supplement N2 - The classification of tumors of the pituitary gland has seen several changes in recent years. The 4th edition of the World Health Organization Classification of Tumours of Endocrine Organs, published in 2017, saw the introduction of a classification based on cell lineage using immunohistochemistry for both pituitary specific hormones as well as pituitary specific transcription factors. The term "hormone-producing" was thus replaced by "-troph." The other major change was that the entity of "atypical adenoma," which was introduced in the 2004 classification, to identify tumors with a poor prognosis, was removed as it failed to identify aggressive tumors. Instead, assessment of markers of proliferation, clinical parameters, such as invasive status and histological subtypes were recommended to identify tumors with aggressive potential. The diagnostic criteria for pituitary carcinoma, however, remained unchanged and continued to be defined as a tumor of adenohypophyseal cells that metastasize craniospinally or systemically. Null cell adenomas were more clearly defined as tumors that did not show any cell-type differentiation, lacking immunoexpression of hormones as well as transcription factors. Since 2017, the classification has continued to evolve with the identification of aggressive histological variants. There is more recently a proposal to change the terminology from pituitary adenoma to pituitary neuroendocrine tumor (PitNET). This review summarizes the recent advances in the classification of pituitary adenomas. SN - 1998-4022 UR - https://www.unboundmedicine.com/medline/citation/32611886/Newer_Concepts_in_the_Classification_of_Pituitary_Adenomas L2 - http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2020;volume=68;issue=7;spage=7;epage=12;aulast=Sathyakumar DB - PRIME DP - Unbound Medicine ER -
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