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Input dependent modulation of olfactory bulb activity by HDB GABAergic projections.
Sci Rep. 2020 Jul 01; 10(1):10696.SR

Abstract

Basal forebrain modulation of central circuits is associated with active sensation, attention, and learning. While cholinergic modulations have been studied extensively the effect of non-cholinergic basal forebrain subpopulations on sensory processing remains largely unclear. Here, we directly compare optogenetic manipulation effects of two major basal forebrain subpopulations on principal neuron activity in an early sensory processing area, i.e. mitral/tufted cells (MTCs) in the olfactory bulb. In contrast to cholinergic projections, which consistently increased MTC firing, activation of GABAergic fibers from basal forebrain to the olfactory bulb leads to differential modulation effects: while spontaneous MTC activity is mainly inhibited, odor-evoked firing is predominantly enhanced. Moreover, sniff-triggered averages revealed an enhancement of maximal sniff evoked firing amplitude and an inhibition of firing rates outside the maximal sniff phase. These findings demonstrate that GABAergic neuromodulation affects MTC firing in a bimodal, sensory-input dependent way, suggesting that GABAergic basal forebrain modulation could be an important factor in attention mediated filtering of sensory information to the brain.

Authors+Show Affiliations

Department of Chemosensation, AG Neuromodulation, Institute for Biology II, RWTH Aachen University, Aachen, 52074, Germany.Department of Chemosensation, AG Neuromodulation, Institute for Biology II, RWTH Aachen University, Aachen, 52074, Germany.Department of Chemosensation, AG Neuromodulation, Institute for Biology II, RWTH Aachen University, Aachen, 52074, Germany. m.rothermel@sensorik.rwth-aachen.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32612119

Citation

Böhm, Erik, et al. "Input Dependent Modulation of Olfactory Bulb Activity By HDB GABAergic Projections." Scientific Reports, vol. 10, no. 1, 2020, p. 10696.
Böhm E, Brunert D, Rothermel M. Input dependent modulation of olfactory bulb activity by HDB GABAergic projections. Sci Rep. 2020;10(1):10696.
Böhm, E., Brunert, D., & Rothermel, M. (2020). Input dependent modulation of olfactory bulb activity by HDB GABAergic projections. Scientific Reports, 10(1), 10696. https://doi.org/10.1038/s41598-020-67276-z
Böhm E, Brunert D, Rothermel M. Input Dependent Modulation of Olfactory Bulb Activity By HDB GABAergic Projections. Sci Rep. 2020 Jul 1;10(1):10696. PubMed PMID: 32612119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Input dependent modulation of olfactory bulb activity by HDB GABAergic projections. AU - Böhm,Erik, AU - Brunert,Daniela, AU - Rothermel,Markus, Y1 - 2020/07/01/ PY - 2020/01/15/received PY - 2020/05/27/accepted PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline SP - 10696 EP - 10696 JF - Scientific reports JO - Sci Rep VL - 10 IS - 1 N2 - Basal forebrain modulation of central circuits is associated with active sensation, attention, and learning. While cholinergic modulations have been studied extensively the effect of non-cholinergic basal forebrain subpopulations on sensory processing remains largely unclear. Here, we directly compare optogenetic manipulation effects of two major basal forebrain subpopulations on principal neuron activity in an early sensory processing area, i.e. mitral/tufted cells (MTCs) in the olfactory bulb. In contrast to cholinergic projections, which consistently increased MTC firing, activation of GABAergic fibers from basal forebrain to the olfactory bulb leads to differential modulation effects: while spontaneous MTC activity is mainly inhibited, odor-evoked firing is predominantly enhanced. Moreover, sniff-triggered averages revealed an enhancement of maximal sniff evoked firing amplitude and an inhibition of firing rates outside the maximal sniff phase. These findings demonstrate that GABAergic neuromodulation affects MTC firing in a bimodal, sensory-input dependent way, suggesting that GABAergic basal forebrain modulation could be an important factor in attention mediated filtering of sensory information to the brain. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/32612119/Input_dependent_modulation_of_olfactory_bulb_activity_by_HDB_GABAergic_projections L2 - http://dx.doi.org/10.1038/s41598-020-67276-z DB - PRIME DP - Unbound Medicine ER -
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