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Clinical Profile of Tic Disorders in Children and Adolescents from a Tertiary Care Center in India.
Indian J Psychol Med. 2020 May-Jun; 42(3):262-267.IJ

Abstract

Background

Tic disorders (TDs) are common neurodevelopmental disorders in children and adolescents. To date, there is very scant literature on TDs in children and adolescents in the Indian setting.

Aim

The objectives of this study were to characterize the clinical profile, including comorbidities and pattern of medication use in the treatment of TDs, in children and adolescents.

Materials and Methods

The present study is a retrospective chart review of children and adolescents up to age 18 years diagnosed with TD in a tertiary care center in India. Data were derived from case records of patients with a diagnosis of TD, coded as F 95 according to ICD 10, from 1st January 2014 to 31st December 2017.

Results

We recruited 85 subjects. The majority (95.29%, n = 81) of them were male, and the mean age of onset was 8.4 years. Chronic tic disorder was the most common subtype, followed by Tourette syndrome and provisional or transient tic disorder. Eighty patients (94%) had a comorbid disorder, with attention deficit hyperactivity disorder being the most common, followed by obsessive compulsive disorder. Eighty-two percent of patients received pharmacotherapy. Risperidone was the most frequently used medication, followed by clonidine, haloperidol, and aripiprazole. Moderate to significant improvement with medications was seen in 88% of the patients.

Conclusion

The present study of children and adolescents with TDs highlights very high rate of comorbidity and a favorable short-term course with medication use.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32612331

Citation

Karki, Utkarsh, et al. "Clinical Profile of Tic Disorders in Children and Adolescents From a Tertiary Care Center in India." Indian Journal of Psychological Medicine, vol. 42, no. 3, 2020, pp. 262-267.
Karki U, Sravanti L, Jacob P, et al. Clinical Profile of Tic Disorders in Children and Adolescents from a Tertiary Care Center in India. Indian J Psychol Med. 2020;42(3):262-267.
Karki, U., Sravanti, L., Jacob, P., Sharma, E., Kommu, J. V. S., & Seshadri, S. P. (2020). Clinical Profile of Tic Disorders in Children and Adolescents from a Tertiary Care Center in India. Indian Journal of Psychological Medicine, 42(3), 262-267. https://doi.org/10.4103/IJPSYM.IJPSYM_324_19
Karki U, et al. Clinical Profile of Tic Disorders in Children and Adolescents From a Tertiary Care Center in India. Indian J Psychol Med. 2020 May-Jun;42(3):262-267. PubMed PMID: 32612331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Profile of Tic Disorders in Children and Adolescents from a Tertiary Care Center in India. AU - Karki,Utkarsh, AU - Sravanti,Lakshmi, AU - Jacob,Preeti, AU - Sharma,Eesha, AU - Kommu,John Vijay Sagar, AU - Seshadri,Shekhar P, Y1 - 2020/04/25/ PY - 2019/08/08/received PY - 2019/12/26/accepted PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline KW - Adolescent KW - India KW - child KW - comorbidity KW - tic disorders KW - •Favorable short-term outcome is seen with medication use. KW - •Ninety-four percent of children with tic disorders had comorbidities. KW - •Risperidone was the most frequently used medication, followed by clonidine, haloperidol, and aripiprazole. SP - 262 EP - 267 JF - Indian journal of psychological medicine JO - Indian J Psychol Med VL - 42 IS - 3 N2 - Background: Tic disorders (TDs) are common neurodevelopmental disorders in children and adolescents. To date, there is very scant literature on TDs in children and adolescents in the Indian setting. Aim: The objectives of this study were to characterize the clinical profile, including comorbidities and pattern of medication use in the treatment of TDs, in children and adolescents. Materials and Methods: The present study is a retrospective chart review of children and adolescents up to age 18 years diagnosed with TD in a tertiary care center in India. Data were derived from case records of patients with a diagnosis of TD, coded as F 95 according to ICD 10, from 1st January 2014 to 31st December 2017. Results: We recruited 85 subjects. The majority (95.29%, n = 81) of them were male, and the mean age of onset was 8.4 years. Chronic tic disorder was the most common subtype, followed by Tourette syndrome and provisional or transient tic disorder. Eighty patients (94%) had a comorbid disorder, with attention deficit hyperactivity disorder being the most common, followed by obsessive compulsive disorder. Eighty-two percent of patients received pharmacotherapy. Risperidone was the most frequently used medication, followed by clonidine, haloperidol, and aripiprazole. Moderate to significant improvement with medications was seen in 88% of the patients. Conclusion: The present study of children and adolescents with TDs highlights very high rate of comorbidity and a favorable short-term course with medication use. SN - 0253-7176 UR - https://www.unboundmedicine.com/medline/citation/32612331/Clinical_Profile_of_Tic_Disorders_in_Children_and_Adolescents_from_a_Tertiary_Care_Center_in_India L2 - https://journals.sagepub.com/doi/10.4103/IJPSYM.IJPSYM_324_19?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=www.ncbi.nlm.nih.gov DB - PRIME DP - Unbound Medicine ER -
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