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Antibiotics Modulate Chemotherapy Efficacy in Patients with Esophageal Cancer.
Cancer Manag Res. 2020; 12:4991-4997.CM

Abstract

Purpose

Accumulating evidence suggests that microbiota dysbiosis induced by antibiotic administration plays a crucial role in regulating the efficacy and toxicity of cancer therapy. We explored the influence of antibiotic administration on the efficacy of chemotherapy in patients with esophageal cancer (EC).

Patients and Methods

EC patients were stratified into two groups: antibiotic-treated group and control group. The antibiotic-treated group included patients who received antibiotics within 60 days before or after chemotherapy initiation, and the control group included patients who did not receive antibiotics within 60 days before or after chemotherapy initiation. Progression-free survival (PFS) and overall survival (OS) curves were constructed using the Kaplan-Meier method. The Cox proportional hazards model was used for univariate and multivariate analyses.

Results

The rate of primary progressive disease in the antibiotic-treated group was significantly higher than that in the control group (36.58% vs 10.45%, p = 0.002) as calculated using the chi-square test. Further, antibiotic administration was associated with shorter PFS (6.7 vs 14.6 months, hazard ratio (HR): 2.545, 95% confidence interval (CI): 1.554-4.168, p < 0.001) and reduced OS (15.0 vs 21.0 months, HR: 2.007, 95% CI: 1.213-3.319, p = 0.007) in univariate analysis. Subsequent multivariate analysis indicated that antibiotic administration was a significant independent prognostic factor for PFS (HR: 2.350, 95% CI: 1.423-3.882, p = 0.001) and OS (HR: 1.900, 95% CI: 1.140-3.167, p = 0.014).

Conclusion

Antibiotic administration was associated with reduced chemotherapy efficacy and poor prognosis in patients with EC.

Authors+Show Affiliations

Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China. Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, People's Republic of China.Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32612386

Citation

Wu, Chensi, et al. "Antibiotics Modulate Chemotherapy Efficacy in Patients With Esophageal Cancer." Cancer Management and Research, vol. 12, 2020, pp. 4991-4997.
Wu C, Lai R, Li J, et al. Antibiotics Modulate Chemotherapy Efficacy in Patients with Esophageal Cancer. Cancer Manag Res. 2020;12:4991-4997.
Wu, C., Lai, R., Li, J., Zhang, J., Zhao, Y., Zhang, X., Zhao, Y., & Guo, Z. (2020). Antibiotics Modulate Chemotherapy Efficacy in Patients with Esophageal Cancer. Cancer Management and Research, 12, 4991-4997. https://doi.org/10.2147/CMAR.S248130
Wu C, et al. Antibiotics Modulate Chemotherapy Efficacy in Patients With Esophageal Cancer. Cancer Manag Res. 2020;12:4991-4997. PubMed PMID: 32612386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotics Modulate Chemotherapy Efficacy in Patients with Esophageal Cancer. AU - Wu,Chensi, AU - Lai,Ruixue, AU - Li,Jing, AU - Zhang,Jingjing, AU - Zhao,Yufei, AU - Zhang,Xiaoyun, AU - Zhao,Yue, AU - Guo,Zhanjun, Y1 - 2020/06/25/ PY - 2020/02/03/received PY - 2020/06/12/accepted PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline KW - OS KW - PFS KW - antibiotics KW - esophageal cancer SP - 4991 EP - 4997 JF - Cancer management and research JO - Cancer Manag Res VL - 12 N2 - Purpose: Accumulating evidence suggests that microbiota dysbiosis induced by antibiotic administration plays a crucial role in regulating the efficacy and toxicity of cancer therapy. We explored the influence of antibiotic administration on the efficacy of chemotherapy in patients with esophageal cancer (EC). Patients and Methods: EC patients were stratified into two groups: antibiotic-treated group and control group. The antibiotic-treated group included patients who received antibiotics within 60 days before or after chemotherapy initiation, and the control group included patients who did not receive antibiotics within 60 days before or after chemotherapy initiation. Progression-free survival (PFS) and overall survival (OS) curves were constructed using the Kaplan-Meier method. The Cox proportional hazards model was used for univariate and multivariate analyses. Results: The rate of primary progressive disease in the antibiotic-treated group was significantly higher than that in the control group (36.58% vs 10.45%, p = 0.002) as calculated using the chi-square test. Further, antibiotic administration was associated with shorter PFS (6.7 vs 14.6 months, hazard ratio (HR): 2.545, 95% confidence interval (CI): 1.554-4.168, p < 0.001) and reduced OS (15.0 vs 21.0 months, HR: 2.007, 95% CI: 1.213-3.319, p = 0.007) in univariate analysis. Subsequent multivariate analysis indicated that antibiotic administration was a significant independent prognostic factor for PFS (HR: 2.350, 95% CI: 1.423-3.882, p = 0.001) and OS (HR: 1.900, 95% CI: 1.140-3.167, p = 0.014). Conclusion: Antibiotic administration was associated with reduced chemotherapy efficacy and poor prognosis in patients with EC. SN - 1179-1322 UR - https://www.unboundmedicine.com/medline/citation/32612386/Antibiotics_Modulate_Chemotherapy_Efficacy_in_Patients_with_Esophageal_Cancer L2 - https://dx.doi.org/10.2147/CMAR.S248130 DB - PRIME DP - Unbound Medicine ER -
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