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The COVID-19 Cytokine Storm; What We Know So Far.
Front Immunol. 2020; 11:1446.FI

Abstract

COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory distress syndrome (ARDS) in about 15 % of the cases. Mortality in COVID-19 patients has been linked to the presence of the so-called "cytokine storm" induced by the virus. Excessive production of proinflammatory cytokines leads to ARDS aggravation and widespread tissue damage resulting in multi-organ failure and death. Targeting cytokines during the management of COVID-19 patients could improve survival rates and reduce mortality.

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Authors+Show Affiliations

Ragab D
Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Salah Eldin H
Department of Chest Diseases, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Taeimah M
Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Khattab R
Department of Radiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Salem R
Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

MeSH

Antibodies, Monoclonal, HumanizedBetacoronavirusCOVID-19Coronavirus InfectionsCytokine Release SyndromeCytokinesHumansInterleukin-6PandemicsPneumonia, ViralReceptors, Interleukin-6Respiratory Distress SyndromeSARS-CoV-2COVID-19 Drug Treatment

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32612617

Clinical Trial Links

Clinical, Functional, Immunological and Genetic Factors on the Severity of the Course of Coronavirus Infection
Study Design of the Diacerein in Patients With Covid-19
(CBDRA60) to Prevent or Reduce Symptoms of COVID-19 and Prevention of Post-Acute Sequelae of SARS-CoV-2 Infection PASC

Citation

Ragab, Dina, et al. "The COVID-19 Cytokine Storm; what We Know so Far." Frontiers in Immunology, vol. 11, 2020, p. 1446.
Ragab D, Salah Eldin H, Taeimah M, et al. The COVID-19 Cytokine Storm; What We Know So Far. Front Immunol. 2020;11:1446.
Ragab, D., Salah Eldin, H., Taeimah, M., Khattab, R., & Salem, R. (2020). The COVID-19 Cytokine Storm; What We Know So Far. Frontiers in Immunology, 11, 1446. https://doi.org/10.3389/fimmu.2020.01446
Ragab D, et al. The COVID-19 Cytokine Storm; what We Know so Far. Front Immunol. 2020;11:1446. PubMed PMID: 32612617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The COVID-19 Cytokine Storm; What We Know So Far. AU - Ragab,Dina, AU - Salah Eldin,Haitham, AU - Taeimah,Mohamed, AU - Khattab,Rasha, AU - Salem,Ramy, Y1 - 2020/06/16/ PY - 2020/4/14/received PY - 2020/6/4/accepted PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/14/medline KW - ARDS KW - COVID-19 KW - IL-6 KW - cytokine KW - storm SP - 1446 EP - 1446 JF - Frontiers in immunology JO - Front Immunol VL - 11 N2 - COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory distress syndrome (ARDS) in about 15 % of the cases. Mortality in COVID-19 patients has been linked to the presence of the so-called "cytokine storm" induced by the virus. Excessive production of proinflammatory cytokines leads to ARDS aggravation and widespread tissue damage resulting in multi-organ failure and death. Targeting cytokines during the management of COVID-19 patients could improve survival rates and reduce mortality. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/32612617/The_COVID_19_Cytokine_Storm DB - PRIME DP - Unbound Medicine ER -