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Skull Metastasis From Uterine Leiomyosarcoma, a Rare Presentation for a Rare Tumor: A Case Report and Review of the Literature.
Front Oncol. 2020; 10:869.FO

Abstract

Uterine leiomyosarcoma (uLMS) is a rare and aggressive malignancy with poor clinical outcomes. Even when localized, uLMS is associated with high rates of local and distant recurrences that are usually fatal. Common sites of recurrence are lung, liver, pelvic lymph nodes, and vertebral and long bones, though atypical patterns of recurrence have been described. Among them, intracranial recurrence appears as a rare finding, almost exceptional in skull and dura. We describe the case of a solitary skull metastasis from uLMS in a 39-year-old woman, which represents the third reported case of skull recurrence in literature. After multidisciplinary discussion, the patient underwent surgery and received adjuvant radiotherapy. After 4 months, she is currently alive, without evidence of extracranial disease. This case highlights the importance of suspecting and recognizing atypical and extremely rare metastasis to this region. We encourage the need for large case series in order to provide further information about cranial recurrences of uLMS taking into account the paucity of data currently available in literature and the frequently unpredictable behavior of this rare and highly lethal disease.

Authors+Show Affiliations

Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.Department of Neurosurgery, Bellaria Hospital, Azienda USL-IRCCS Institute of Neurological Sciences, Bologna, Italy.Anatomic Pathology, Ospedale Bellaria, Bologna, Italy.Gynecologic Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy.Gynecologic Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy.Department of Radiotherapy, Bellaria Hospital, Bologna, Italy.Department of Radiotherapy, Bellaria Hospital, Bologna, Italy.Radiotherapy Unit, Azienda Ospedaliero Universitaria, Ospedali Riuniti Ancona, Ancona, Italy.ASUR Marche, Zona Territoriale 9, Macerata Hospital, Macerata, Italy.Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. "Giorgio Prodi" Cancer Research Center, University of Bologna, Bologna, Italy.Medical Oncology Unit, S.Orsola-Malpighi University Hospital, Bologna, Italy.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32612948

Citation

Rizzo, Alessandro, et al. "Skull Metastasis From Uterine Leiomyosarcoma, a Rare Presentation for a Rare Tumor: a Case Report and Review of the Literature." Frontiers in Oncology, vol. 10, 2020, p. 869.
Rizzo A, Nigro MC, Ramponi V, et al. Skull Metastasis From Uterine Leiomyosarcoma, a Rare Presentation for a Rare Tumor: A Case Report and Review of the Literature. Front Oncol. 2020;10:869.
Rizzo, A., Nigro, M. C., Ramponi, V., Gallo, C., Perrone, A. M., De Iaco, P., Frezza, G., Balestrini, D., Di Benedetto, M., Morbiducci, J., Pantaleo, M. A., & Nannini, M. (2020). Skull Metastasis From Uterine Leiomyosarcoma, a Rare Presentation for a Rare Tumor: A Case Report and Review of the Literature. Frontiers in Oncology, 10, 869. https://doi.org/10.3389/fonc.2020.00869
Rizzo A, et al. Skull Metastasis From Uterine Leiomyosarcoma, a Rare Presentation for a Rare Tumor: a Case Report and Review of the Literature. Front Oncol. 2020;10:869. PubMed PMID: 32612948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skull Metastasis From Uterine Leiomyosarcoma, a Rare Presentation for a Rare Tumor: A Case Report and Review of the Literature. AU - Rizzo,Alessandro, AU - Nigro,Maria Concetta, AU - Ramponi,Vania, AU - Gallo,Carmine, AU - Perrone,Anna Myriam, AU - De Iaco,Pierandrea, AU - Frezza,Giovanni, AU - Balestrini,Damiano, AU - Di Benedetto,Maika, AU - Morbiducci,Jarno, AU - Pantaleo,Maria Abbondanza, AU - Nannini,Margherita, Y1 - 2020/06/16/ PY - 2020/02/17/received PY - 2020/05/04/accepted PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline KW - intracranial recurrence KW - skull metastasis KW - uterine cancer KW - uterine leiomyosarcoma KW - uterine sarcoma SP - 869 EP - 869 JF - Frontiers in oncology JO - Front Oncol VL - 10 N2 - Uterine leiomyosarcoma (uLMS) is a rare and aggressive malignancy with poor clinical outcomes. Even when localized, uLMS is associated with high rates of local and distant recurrences that are usually fatal. Common sites of recurrence are lung, liver, pelvic lymph nodes, and vertebral and long bones, though atypical patterns of recurrence have been described. Among them, intracranial recurrence appears as a rare finding, almost exceptional in skull and dura. We describe the case of a solitary skull metastasis from uLMS in a 39-year-old woman, which represents the third reported case of skull recurrence in literature. After multidisciplinary discussion, the patient underwent surgery and received adjuvant radiotherapy. After 4 months, she is currently alive, without evidence of extracranial disease. This case highlights the importance of suspecting and recognizing atypical and extremely rare metastasis to this region. We encourage the need for large case series in order to provide further information about cranial recurrences of uLMS taking into account the paucity of data currently available in literature and the frequently unpredictable behavior of this rare and highly lethal disease. SN - 2234-943X UR - https://www.unboundmedicine.com/medline/citation/32612948/Skull_Metastasis_From_Uterine_Leiomyosarcoma,_a_Rare_Presentation_for_a_Rare_Tumor:_A_Case_Report_and_Review_of_the_Literature L2 - https://doi.org/10.3389/fonc.2020.00869 DB - PRIME DP - Unbound Medicine ER -
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