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Clinical Features of 33 Cases in Children Infected With SARS-CoV-2 in Anhui Province, China-A Multi-Center Retrospective Cohort Study.
Front Public Health. 2020; 8:255.FP

Abstract

Background:

As of 23rd February 2020, China had 77,048 patients with confirmed SARS-CoV-2 infections, and only 2. 1% of patients were under the age of 19 years. Morbidity among children was much lower, with milder or absent signs and symptoms; chest CT scans showed milder symptoms, if at all, compared to adults.

Objective:

Report the epidemiological, clinical features, laboratory, radiological characteristics, and treatment of SARS-CoV-2 infections. Compare additional signs and symptoms, investigate familial clustering, compare laboratory results, and find out relevance between age and typical chest CT scans in patients.

Methods:

We studied 33 young patients with laboratory-confirmed SARS-CoV-2 infection in Anhui Province of China by 16th February 2020. Their signs, symptoms, and familial clustering were analyzed. We compared the laboratory test results, age, and gender among three parts based on their chest CT scans.

Results:

Familial clustering was seen in 30 (30/33; 90.91%) patients; three families had seven confirmed members infected with the disease. Eight (8/33; 24.24%) patients had no symptoms, 12 (12/33; 36.36%) patients had only fever, nine (9/33; 27.27%) patients had fever and additional symptoms, and 12 (12/33; 36.36%) patients had no fever. Dry cough was the most common additional symptom. In 25 (25/33; 75.76%) patients, the percent of lymphocytes decreased; 26 (26/33; 78.79%) patients were older than 7 years. More male than female patients and patients older than 8 years showed typical abnormalities in the chest CT scans (P = 0.038). Only two 18 years old patients had hepatic injury.

Conclusion:

Children's infection is mild and familial clustering was the most common channel. The older patients had more typical ground glass opacity (GGO) or consolidation in chest CT scans. Cases without fever strongly suggested that non-symptomatic children should not be assumed to be free of infection when their family members have confirmed infection. Most children showed clinical features distinguishable from adults and with increased susceptibility within family members.

Authors+Show Affiliations

Pediatric Department Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China.Pediatric Department Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32612971

Citation

Zhang, Lan, and Songming Huang. "Clinical Features of 33 Cases in Children Infected With SARS-CoV-2 in Anhui Province, China-A Multi-Center Retrospective Cohort Study." Frontiers in Public Health, vol. 8, 2020, p. 255.
Zhang L, Huang S. Clinical Features of 33 Cases in Children Infected With SARS-CoV-2 in Anhui Province, China-A Multi-Center Retrospective Cohort Study. Front Public Health. 2020;8:255.
Zhang, L., & Huang, S. (2020). Clinical Features of 33 Cases in Children Infected With SARS-CoV-2 in Anhui Province, China-A Multi-Center Retrospective Cohort Study. Frontiers in Public Health, 8, 255. https://doi.org/10.3389/fpubh.2020.00255
Zhang L, Huang S. Clinical Features of 33 Cases in Children Infected With SARS-CoV-2 in Anhui Province, China-A Multi-Center Retrospective Cohort Study. Front Public Health. 2020;8:255. PubMed PMID: 32612971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Features of 33 Cases in Children Infected With SARS-CoV-2 in Anhui Province, China-A Multi-Center Retrospective Cohort Study. AU - Zhang,Lan, AU - Huang,Songming, Y1 - 2020/06/16/ PY - 2020/03/27/received PY - 2020/05/21/accepted PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline KW - COVID-19 KW - SARS-CoV-2 KW - chest CT KW - children KW - familial clustering KW - susceptibility SP - 255 EP - 255 JF - Frontiers in public health JO - Front Public Health VL - 8 N2 - Background: As of 23rd February 2020, China had 77,048 patients with confirmed SARS-CoV-2 infections, and only 2. 1% of patients were under the age of 19 years. Morbidity among children was much lower, with milder or absent signs and symptoms; chest CT scans showed milder symptoms, if at all, compared to adults. Objective: Report the epidemiological, clinical features, laboratory, radiological characteristics, and treatment of SARS-CoV-2 infections. Compare additional signs and symptoms, investigate familial clustering, compare laboratory results, and find out relevance between age and typical chest CT scans in patients. Methods: We studied 33 young patients with laboratory-confirmed SARS-CoV-2 infection in Anhui Province of China by 16th February 2020. Their signs, symptoms, and familial clustering were analyzed. We compared the laboratory test results, age, and gender among three parts based on their chest CT scans. Results: Familial clustering was seen in 30 (30/33; 90.91%) patients; three families had seven confirmed members infected with the disease. Eight (8/33; 24.24%) patients had no symptoms, 12 (12/33; 36.36%) patients had only fever, nine (9/33; 27.27%) patients had fever and additional symptoms, and 12 (12/33; 36.36%) patients had no fever. Dry cough was the most common additional symptom. In 25 (25/33; 75.76%) patients, the percent of lymphocytes decreased; 26 (26/33; 78.79%) patients were older than 7 years. More male than female patients and patients older than 8 years showed typical abnormalities in the chest CT scans (P = 0.038). Only two 18 years old patients had hepatic injury. Conclusion: Children's infection is mild and familial clustering was the most common channel. The older patients had more typical ground glass opacity (GGO) or consolidation in chest CT scans. Cases without fever strongly suggested that non-symptomatic children should not be assumed to be free of infection when their family members have confirmed infection. Most children showed clinical features distinguishable from adults and with increased susceptibility within family members. SN - 2296-2565 UR - https://www.unboundmedicine.com/medline/citation/32612971/Clinical_Features_of_33_Cases_in_Children_Infected_With_SARS-CoV-2_in_Anhui_Province,_China-A_Multi-Center_Retrospective_Cohort_Study L2 - https://doi.org/10.3389/fpubh.2020.00255 DB - PRIME DP - Unbound Medicine ER -
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