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Susceptibilities of Malassezia strains from pityriasis versicolor, Malassezia folliculitis and seborrheic dermatitis to antifungal drugs.
Heliyon. 2020 Jun; 6(6):e04203.H

Abstract

The human pathogenic yeast genus Malassezia may be an etiological agent of skin disorders and has received considerable attention from dermatologists in recent years. To investigate the different susceptibilities of Malassezia species to four antifungal drugs, we isolated a total of 244 Malassezia strains and identified six species of Malassezia from patients with clinical skin diseases. The minimum inhibitory concentration (MIC) of the four antifungal drugs was obtained by comparing the susceptibility of the isolated Malassezia strains to four antifungal drugs (ketoconazole (KTZ), itraconazole (ITZ), fluconazole (FLC) and amphotericin B (Am B)). We demonstrated that M. furfur, M. sympodialis, M. pachydermatis and M. globosa are the most common Malassezia species in the three skin diseases. The MICs of KTZ, ITZ, FLC and Am B against M. furfur, M. sympodialis, M. pachydermatis and M. globosa ranged from 0.03 - 16 mg/L, 0.03 - 2.0 mg/L, 0.03 - 8 mg/L, and 13 - 64 mg/L, respectively. The sensitivities of Malassezia to the four antifungal drugs from high to low were ITZ ≥ KTZ > Am B > FLC. The susceptibilities of the various Malassezia species to the four antifungal drugs were different, and the susceptibility of M. furfur to KTZ was significantly different from those of the three skin diseases (pityriasis versicolor, Malassezia folliculitis and seborrheic dermatitis). Our results suggested that the MIC analysis of the four antifungal drugs would be helpful in preventing drug resistance in the clinical screening of Malassezia and choosing better antifungal drugs to treat Malassezia-associated skin diseases.

Authors+Show Affiliations

Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China. Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, 2901, Caolang Road, Jinshan District, Shanghai, China. Department of Dermatology, Zigong First People's Hospital, Zigong, Sichuan, China.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China. Yantai Affiliated Hospital of Binzhou Medical University, Shandong, China.Yantai Affiliated Hospital of Binzhou Medical University, Shandong, China.Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, 2901, Caolang Road, Jinshan District, Shanghai, China.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, 2901, Caolang Road, Jinshan District, Shanghai, China.Department of Dermatology, Zigong First People's Hospital, Zigong, Sichuan, China.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32613106

Citation

Wang, Kaiqin, et al. "Susceptibilities of Malassezia Strains From Pityriasis Versicolor, Malassezia Folliculitis and Seborrheic Dermatitis to Antifungal Drugs." Heliyon, vol. 6, no. 6, 2020, pp. e04203.
Wang K, Cheng L, Li W, et al. Susceptibilities of Malassezia strains from pityriasis versicolor, Malassezia folliculitis and seborrheic dermatitis to antifungal drugs. Heliyon. 2020;6(6):e04203.
Wang, K., Cheng, L., Li, W., Jiang, H., Zhang, X., Liu, S., Huang, Y., Qiang, M., Dong, T., Li, Y., Wang, J., Feng, S., & Li, H. (2020). Susceptibilities of Malassezia strains from pityriasis versicolor, Malassezia folliculitis and seborrheic dermatitis to antifungal drugs. Heliyon, 6(6), e04203. https://doi.org/10.1016/j.heliyon.2020.e04203
Wang K, et al. Susceptibilities of Malassezia Strains From Pityriasis Versicolor, Malassezia Folliculitis and Seborrheic Dermatitis to Antifungal Drugs. Heliyon. 2020;6(6):e04203. PubMed PMID: 32613106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptibilities of Malassezia strains from pityriasis versicolor, Malassezia folliculitis and seborrheic dermatitis to antifungal drugs. AU - Wang,Kaiqin, AU - Cheng,Lu, AU - Li,Wenshuang, AU - Jiang,Hui, AU - Zhang,Xiaofang, AU - Liu,Shanshan, AU - Huang,Yunli, AU - Qiang,Mingyue, AU - Dong,Tianxiang, AU - Li,Yuye, AU - Wang,Jin, AU - Feng,Shike, AU - Li,Hongbin, Y1 - 2020/06/20/ PY - 2019/05/13/received PY - 2020/06/05/revised PY - 2020/06/09/accepted PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline KW - Antifungal drugs KW - Clinical genetics KW - Gastrointestinal system KW - Infectious disease KW - Malassezia KW - Malassezia folliculitis KW - Pathology KW - Pityriasis versicolor KW - Public health KW - Seborrheic dermatitis SP - e04203 EP - e04203 JF - Heliyon JO - Heliyon VL - 6 IS - 6 N2 - The human pathogenic yeast genus Malassezia may be an etiological agent of skin disorders and has received considerable attention from dermatologists in recent years. To investigate the different susceptibilities of Malassezia species to four antifungal drugs, we isolated a total of 244 Malassezia strains and identified six species of Malassezia from patients with clinical skin diseases. The minimum inhibitory concentration (MIC) of the four antifungal drugs was obtained by comparing the susceptibility of the isolated Malassezia strains to four antifungal drugs (ketoconazole (KTZ), itraconazole (ITZ), fluconazole (FLC) and amphotericin B (Am B)). We demonstrated that M. furfur, M. sympodialis, M. pachydermatis and M. globosa are the most common Malassezia species in the three skin diseases. The MICs of KTZ, ITZ, FLC and Am B against M. furfur, M. sympodialis, M. pachydermatis and M. globosa ranged from 0.03 - 16 mg/L, 0.03 - 2.0 mg/L, 0.03 - 8 mg/L, and 13 - 64 mg/L, respectively. The sensitivities of Malassezia to the four antifungal drugs from high to low were ITZ ≥ KTZ > Am B > FLC. The susceptibilities of the various Malassezia species to the four antifungal drugs were different, and the susceptibility of M. furfur to KTZ was significantly different from those of the three skin diseases (pityriasis versicolor, Malassezia folliculitis and seborrheic dermatitis). Our results suggested that the MIC analysis of the four antifungal drugs would be helpful in preventing drug resistance in the clinical screening of Malassezia and choosing better antifungal drugs to treat Malassezia-associated skin diseases. SN - 2405-8440 UR - https://www.unboundmedicine.com/medline/citation/32613106/Susceptibilities_of_Malassezia_strains_from_pityriasis_versicolor,_Malassezia_folliculitis_and_seborrheic_dermatitis_to_antifungal_drugs L2 - https://linkinghub.elsevier.com/retrieve/pii/S2405-8440(20)31047-1 DB - PRIME DP - Unbound Medicine ER -
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