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Primary recurrent orbital schwannoma treated with surgical excision and Mitomycin-C.
Am J Ophthalmol Case Rep. 2020 Sep; 19:100784.AJ

Abstract

Purpose

Primary orbital schwannoma (POS) is a slow growing, benign encapsulated peripheral nerve sheath tumor that occurs infrequently within the orbit. Recurrence of POS is extremely rare. Previous speculations for reasons of recurrence include incomplete excision and tumor seeding.

Observations

We present the fifth case reported in the literature to date of POS that had 2 episodes of recurrences within 8 years after diagnosis, in which rapid and insidious relapses were observed after initial surgical resection. This is also the first reported recurrent POS in which topical Mitomycin-C (MMC) has been employed during surgical excision with an aim to prevent further recurrences.

Conclusions

AND IMPORTANCE: Whilst complete surgical excision remained the standard for management for most POS, when there are multiple recurrences and in cases where total excision is not possible, addition of topical MMC may be an option that may bring about tumour regression as demonstrated in our case.

Authors+Show Affiliations

Department of Ophthalmology, Tung Wah Eastern Hosptial, Causewaybay, Hong Kong.Department of Ophthalmology, Tuen Mun Eye Centre, Tuen Mun Hospital, Hong Kong.Department of Ophthalmology, Tung Wah Eastern Hosptial, Causewaybay, Hong Kong.Department of Ophthalmology, Tung Wah Eastern Hosptial, Causewaybay, Hong Kong.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32613139

Citation

Leung, Kai Ching Peter, et al. "Primary Recurrent Orbital Schwannoma Treated With Surgical Excision and Mitomycin-C." American Journal of Ophthalmology Case Reports, vol. 19, 2020, p. 100784.
Leung KCP, Lam NKY, Chan E, et al. Primary recurrent orbital schwannoma treated with surgical excision and Mitomycin-C. Am J Ophthalmol Case Rep. 2020;19:100784.
Leung, K. C. P., Lam, N. K. Y., Chan, E., & Ko, T. C. S. (2020). Primary recurrent orbital schwannoma treated with surgical excision and Mitomycin-C. American Journal of Ophthalmology Case Reports, 19, 100784. https://doi.org/10.1016/j.ajoc.2020.100784
Leung KCP, et al. Primary Recurrent Orbital Schwannoma Treated With Surgical Excision and Mitomycin-C. Am J Ophthalmol Case Rep. 2020;19:100784. PubMed PMID: 32613139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary recurrent orbital schwannoma treated with surgical excision and Mitomycin-C. AU - Leung,Kai Ching Peter, AU - Lam,Nerissa Kei Yen, AU - Chan,Edwin, AU - Ko,Tak Chuen Simon, Y1 - 2020/06/15/ PY - 2019/04/15/received PY - 2020/06/08/revised PY - 2020/06/08/accepted PY - 2020/7/3/entrez PY - 2020/7/3/pubmed PY - 2020/7/3/medline KW - CT, Computer tomography KW - MMC, Mitomycin C KW - MRI, Magnetic resonance imaging KW - Mitomycin C KW - NF2, Neurofibromatosis type 2 KW - Neurilemmoma KW - PNST, Peripheral nerve sheath tumour KW - POS, Primary orbital schwannoma KW - Peripheral nerve sheath tumour KW - Primary orbital schwannomas KW - Schwannoma SP - 100784 EP - 100784 JF - American journal of ophthalmology case reports JO - Am J Ophthalmol Case Rep VL - 19 N2 - Purpose: Primary orbital schwannoma (POS) is a slow growing, benign encapsulated peripheral nerve sheath tumor that occurs infrequently within the orbit. Recurrence of POS is extremely rare. Previous speculations for reasons of recurrence include incomplete excision and tumor seeding. Observations: We present the fifth case reported in the literature to date of POS that had 2 episodes of recurrences within 8 years after diagnosis, in which rapid and insidious relapses were observed after initial surgical resection. This is also the first reported recurrent POS in which topical Mitomycin-C (MMC) has been employed during surgical excision with an aim to prevent further recurrences. Conclusions: AND IMPORTANCE: Whilst complete surgical excision remained the standard for management for most POS, when there are multiple recurrences and in cases where total excision is not possible, addition of topical MMC may be an option that may bring about tumour regression as demonstrated in our case. SN - 2451-9936 UR - https://www.unboundmedicine.com/medline/citation/32613139/Primary_recurrent_orbital_schwannoma_treated_with_surgical_excision_and_Mitomycin-C L2 - https://linkinghub.elsevier.com/retrieve/pii/S2451-9936(19)30193-8 DB - PRIME DP - Unbound Medicine ER -
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