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Severe immune thrombocytopenic purpura in critical COVID-19.
Int J Hematol. 2020 Nov; 112(5):746-750.IJ

Abstract

COVID-19 is a new disease with many undescribed clinical manifestations. We report herein a case of severe immune thrombocytopenic purpura (ITP) in a critical COVID-19 patient. A patient presented a severe episode of immune thrombocytopenia (< 10 × 109/L) 20 days after admission for a critical COVID-19. This thrombocytopenia was associated with a life-threatening bleeding. Response to first-line therapies was delayed as it took up to 13 days after initiation of intravenous immunoglobulin and high-dose dexamethasone to observe an increase in platelet count. COVID-19 may be associated with late presenting severe ITP. Such ITP may also be relatively resistant to first-line agents. Hematological manifestations of COVID-19, such as the ones associated with life-threatening bleeding, must be recognized.

Authors+Show Affiliations

Department of Medicine, Université de Montréal, Montréal, Canada.Department of Medicine, Université de Montréal, Montréal, Canada.Department of Medicine - Critical Care Division, Centre hospitalier de I'Université de Montréal, Montréal, Canada.Department of Medicine - Hematology Division, Centre hospitalier de I'Université de Montréal, Montréal, Canada.Department of Medicine - Critical Care Division, Centre hospitalier de I'Université de Montréal, Montréal, Canada. francois.martin.carrier@umontreal.ca. Department of Medicine - Hematology Division, Centre hospitalier de I'Université de Montréal, Montréal, Canada. francois.martin.carrier@umontreal.ca. Department of Anesthesiology, Centre hospitalier de I'Université de Montréal, Montréal, Canada. francois.martin.carrier@umontreal.ca. Carrefour de I'Innovation, Centre de recherche du Centre hospitalier de I'Université de Montréal (CRCHUM), 900, rue St-Denis, porte S03-434, Montréal, QC, H2X 0A9, Canada. francois.martin.carrier@umontreal.ca.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32613314

Citation

Lévesque, Valérie, et al. "Severe Immune Thrombocytopenic Purpura in Critical COVID-19." International Journal of Hematology, vol. 112, no. 5, 2020, pp. 746-750.
Lévesque V, Millaire É, Corsilli D, et al. Severe immune thrombocytopenic purpura in critical COVID-19. Int J Hematol. 2020;112(5):746-750.
Lévesque, V., Millaire, É., Corsilli, D., Rioux-Massé, B., & Carrier, F. M. (2020). Severe immune thrombocytopenic purpura in critical COVID-19. International Journal of Hematology, 112(5), 746-750. https://doi.org/10.1007/s12185-020-02931-9
Lévesque V, et al. Severe Immune Thrombocytopenic Purpura in Critical COVID-19. Int J Hematol. 2020;112(5):746-750. PubMed PMID: 32613314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe immune thrombocytopenic purpura in critical COVID-19. AU - Lévesque,Valérie, AU - Millaire,Émilie, AU - Corsilli,Daniel, AU - Rioux-Massé,Benjamin, AU - Carrier,François-Martin, Y1 - 2020/07/01/ PY - 2020/06/01/received PY - 2020/06/24/accepted PY - 2020/06/18/revised PY - 2020/7/3/pubmed PY - 2020/10/24/medline PY - 2020/7/3/entrez KW - Bleeding KW - COVID-19 KW - Corticosteroids KW - Immunoglobulin KW - Thrombocytopenia SP - 746 EP - 750 JF - International journal of hematology JO - Int J Hematol VL - 112 IS - 5 N2 - COVID-19 is a new disease with many undescribed clinical manifestations. We report herein a case of severe immune thrombocytopenic purpura (ITP) in a critical COVID-19 patient. A patient presented a severe episode of immune thrombocytopenia (< 10 × 109/L) 20 days after admission for a critical COVID-19. This thrombocytopenia was associated with a life-threatening bleeding. Response to first-line therapies was delayed as it took up to 13 days after initiation of intravenous immunoglobulin and high-dose dexamethasone to observe an increase in platelet count. COVID-19 may be associated with late presenting severe ITP. Such ITP may also be relatively resistant to first-line agents. Hematological manifestations of COVID-19, such as the ones associated with life-threatening bleeding, must be recognized. SN - 1865-3774 UR - https://www.unboundmedicine.com/medline/citation/32613314/Severe_immune_thrombocytopenic_purpura_in_critical_COVID_19_ L2 - https://dx.doi.org/10.1007/s12185-020-02931-9 DB - PRIME DP - Unbound Medicine ER -