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Cardiac magnetic resonance imaging in Chagas' disease: a parallel with electrophysiologic studies.
Int J Cardiovasc Imaging. 2020 Jul 01 [Online ahead of print]IJ

Abstract

Chagas' disease (CD), caused by the parasite Trypanosoma cruzi, is the leading cause of cardiac disability from infectious diseases in Central and South America. The disease progresses through an extended, asymptomatic form characterized by latency without clinical manifestations into a symptomatic form with cardiac and gastro-intestinal manifestations. In the terminal phase, chronic Chagas' myocarditis results in extensive myocardial fibrosis, chamber enlargement with aneurysms and ventricular tachycardia (VT). Cardiac magnetic resonance imaging (CMR) has proven useful in characterizing myocardial fibrosis (MF). Sub-epicardial and mid-wall fibrosis are less common patterns of MF in CHD than transmural scar, which resembles myocardial infarction. Commonly involved areas of MF include the left ventricular apex and basal infero-lateral wall, suggesting a role for watershed ischemia in the pathophysiology of MF. Electrophysiology studies have helped refine the relationship between MF and VT in this setting. This article reviews the patterns of MF in CHD and correlate these patterns with electrogram patterns to predict risk of ventricular arrhythmias and sudden death.

Authors+Show Affiliations

Internal Medicine Residency Program, Cleveland Clinic Foundation, Cleveland, OH, USA.Department of Diagnostic Radiology, Mayo Clinic, Jacksonville, FL, USA.Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.Department of Cardiovascular Imaging, Fundación Cardioinfantil, Calle 163a #13B-60, 110131, Bogotá, Colombia. hmedina@cardioinfantil.org.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32613382

Citation

Duran-Crane, Alejandro, et al. "Cardiac Magnetic Resonance Imaging in Chagas' Disease: a Parallel With Electrophysiologic Studies." The International Journal of Cardiovascular Imaging, 2020.
Duran-Crane A, Rojas CA, Cooper LT, et al. Cardiac magnetic resonance imaging in Chagas' disease: a parallel with electrophysiologic studies. Int J Cardiovasc Imaging. 2020.
Duran-Crane, A., Rojas, C. A., Cooper, L. T., & Medina, H. M. (2020). Cardiac magnetic resonance imaging in Chagas' disease: a parallel with electrophysiologic studies. The International Journal of Cardiovascular Imaging. https://doi.org/10.1007/s10554-020-01925-2
Duran-Crane A, et al. Cardiac Magnetic Resonance Imaging in Chagas' Disease: a Parallel With Electrophysiologic Studies. Int J Cardiovasc Imaging. 2020 Jul 1; PubMed PMID: 32613382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac magnetic resonance imaging in Chagas' disease: a parallel with electrophysiologic studies. AU - Duran-Crane,Alejandro, AU - Rojas,Carlos A, AU - Cooper,Leslie T, AU - Medina,Hector M, Y1 - 2020/07/01/ PY - 2020/03/02/received PY - 2020/06/25/accepted PY - 2020/7/3/entrez KW - Chagas’ heart disease KW - Magnetic resonance imaging KW - Myocardial fibrosis KW - Radiofrequency ablation KW - Ventricular arrhythmias JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging N2 - Chagas' disease (CD), caused by the parasite Trypanosoma cruzi, is the leading cause of cardiac disability from infectious diseases in Central and South America. The disease progresses through an extended, asymptomatic form characterized by latency without clinical manifestations into a symptomatic form with cardiac and gastro-intestinal manifestations. In the terminal phase, chronic Chagas' myocarditis results in extensive myocardial fibrosis, chamber enlargement with aneurysms and ventricular tachycardia (VT). Cardiac magnetic resonance imaging (CMR) has proven useful in characterizing myocardial fibrosis (MF). Sub-epicardial and mid-wall fibrosis are less common patterns of MF in CHD than transmural scar, which resembles myocardial infarction. Commonly involved areas of MF include the left ventricular apex and basal infero-lateral wall, suggesting a role for watershed ischemia in the pathophysiology of MF. Electrophysiology studies have helped refine the relationship between MF and VT in this setting. This article reviews the patterns of MF in CHD and correlate these patterns with electrogram patterns to predict risk of ventricular arrhythmias and sudden death. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/32613382/Cardiac_magnetic_resonance_imaging_in_Chagas'_disease:_a_parallel_with_electrophysiologic_studies L2 - https://doi.org/10.1007/s10554-020-01925-2 DB - PRIME DP - Unbound Medicine ER -
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