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Purple Tulip Extract improves signs of skin aging through dermal structural modulation as shown by genomic, protein expression and skin appearance of volunteers studied.
J Cosmet Dermatol. 2020 Jul 02 [Online ahead of print]JC

Abstract

BACKGROUND

Purple tulip extract is a rich source of flavonoids which are powerful antioxidants and can hence be considered as an ideal candidate for use in skin care products.

OBJECTIVES

We aimed to evaluate the effects of purple tulip extract on skin quality and to determine its molecular modes of interaction.

METHODS

A pangenomic study on human skin fibroblasts was carried out to analyse multiple changes in gene expression. Ex vivo studies of human skin explants exposed to ultraviolet (UV) irradiation or H2 O2 were performed to assess modulations of protein expression. Finally, a clinical assay was carried out to evaluate the efficacy of purple tulip extract on skin appearance and condition of aged women.

RESULTS

Genetic modulation analyses led us to infer the induction of many biological functions including cell differentiation, proliferation, migration, inflammatory responses, and matrix remodelling. The ex vivo studies revealed an enhancement of the collagen network and increased expression of glycosaminoglycans (GAG), fibronectin and collagen VI. Finally, the clinical study highlighted the potential anti-ageing properties of the purple tulip extract which decreased the relaxation of the oval face and improved skin elasticity after 28 days of treatment. Significant reductions of the length and depth of the nasolabial wrinkles were also observed.

CONCLUSION

Our genomics data on the effect of purple tulip extract on the ex vivo UV challenged skin, showed that genes responsible for, amongst others, the upkeep of the skin, such as collagen induction, immune cell proliferation and epidermal repair, were all upregulated. More importantly, the clinical study corroborated these data by the visible and measurable effects of the topical purple tulip extract on the aged skin of 22 women, further demonstrating the beneficial impact of the extract on aged skin.

Authors+Show Affiliations

Ales Groupe, Bezons, France.D.I.V.A. Expertise, Toulouse, France.Gredeco, , Paris, France.Ales Groupe, Bezons, France.Ales Groupe, Bezons, France.Ales Groupe, Bezons, France.GreenPharma, Orléans, France.GreenPharma, Orléans, France.Ales Groupe, Bezons, France.Ales Groupe, Bezons, France.Gredeco, , Paris, France.D.I.V.A. Expertise, Toulouse, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32613704

Citation

Hajem, Neïla, et al. "Purple Tulip Extract Improves Signs of Skin Aging Through Dermal Structural Modulation as Shown By Genomic, Protein Expression and Skin Appearance of Volunteers Studied." Journal of Cosmetic Dermatology, 2020.
Hajem N, Manzato L, Branchet MC, et al. Purple Tulip Extract improves signs of skin aging through dermal structural modulation as shown by genomic, protein expression and skin appearance of volunteers studied. J Cosmet Dermatol. 2020.
Hajem, N., Manzato, L., Branchet, M. C., Herlin, A., Hassanaly, S., Huguet, E., Himbert, F., Bernard, P., Dussert, A. S., Choulot, J. C., Boisnic, S., & Kéophiphath, M. (2020). Purple Tulip Extract improves signs of skin aging through dermal structural modulation as shown by genomic, protein expression and skin appearance of volunteers studied. Journal of Cosmetic Dermatology. https://doi.org/10.1111/jocd.13583
Hajem N, et al. Purple Tulip Extract Improves Signs of Skin Aging Through Dermal Structural Modulation as Shown By Genomic, Protein Expression and Skin Appearance of Volunteers Studied. J Cosmet Dermatol. 2020 Jul 2; PubMed PMID: 32613704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Purple Tulip Extract improves signs of skin aging through dermal structural modulation as shown by genomic, protein expression and skin appearance of volunteers studied. AU - Hajem,Neïla, AU - Manzato,Léana, AU - Branchet,Marie-Christine, AU - Herlin,Amélie, AU - Hassanaly,Shalina, AU - Huguet,Elise, AU - Himbert,Frank, AU - Bernard,Philippe, AU - Dussert,Anne-Sophie, AU - Choulot,Jean-Christophe, AU - Boisnic,Sylvie, AU - Kéophiphath,Mayoura, Y1 - 2020/07/02/ PY - 2020/7/3/entrez KW - Purple tulip extract KW - ageing KW - cell culture KW - extracellular matrix KW - skin physiology/structure JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol N2 - BACKGROUND: Purple tulip extract is a rich source of flavonoids which are powerful antioxidants and can hence be considered as an ideal candidate for use in skin care products. OBJECTIVES: We aimed to evaluate the effects of purple tulip extract on skin quality and to determine its molecular modes of interaction. METHODS: A pangenomic study on human skin fibroblasts was carried out to analyse multiple changes in gene expression. Ex vivo studies of human skin explants exposed to ultraviolet (UV) irradiation or H2 O2 were performed to assess modulations of protein expression. Finally, a clinical assay was carried out to evaluate the efficacy of purple tulip extract on skin appearance and condition of aged women. RESULTS: Genetic modulation analyses led us to infer the induction of many biological functions including cell differentiation, proliferation, migration, inflammatory responses, and matrix remodelling. The ex vivo studies revealed an enhancement of the collagen network and increased expression of glycosaminoglycans (GAG), fibronectin and collagen VI. Finally, the clinical study highlighted the potential anti-ageing properties of the purple tulip extract which decreased the relaxation of the oval face and improved skin elasticity after 28 days of treatment. Significant reductions of the length and depth of the nasolabial wrinkles were also observed. CONCLUSION: Our genomics data on the effect of purple tulip extract on the ex vivo UV challenged skin, showed that genes responsible for, amongst others, the upkeep of the skin, such as collagen induction, immune cell proliferation and epidermal repair, were all upregulated. More importantly, the clinical study corroborated these data by the visible and measurable effects of the topical purple tulip extract on the aged skin of 22 women, further demonstrating the beneficial impact of the extract on aged skin. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/32613704/Purple_Tulip_Extract_improves_signs_of_skin_aging_through_dermal_structural_modulation_as_shown_by_genomic,_protein_expression_and_skin_appearance_of_volunteers_studied L2 - https://doi.org/10.1111/jocd.13583 DB - PRIME DP - Unbound Medicine ER -
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