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Periodically Ordered, Nuclease-Resistant DNA Nanowires Decorated with Cell-Specific Aptamers as Selective Theranostic Agents.
Angew Chem Int Ed Engl. 2020 Jul 02 [Online ahead of print]AC

Abstract

DNA nanostructures have shown potentials in cancer therapy. However, current clinical practice is hampered by the difficulty to deliver them into cancer cells and susceptibility to nuclease degradation. To overcome these limitations, we report herein a periodically-ordered nick-hidden DNA nanowire (NW) with high serum stability and active targeting functionality. The inner core is made of multiple-connected DNA double helices and the outer shell is composed of regularly-arranged standing-up hairpin aptamers. All terminals of the components are hidden from nuclease attacks while the target-binding sites are exposed to allow delivery to the cancer target. The DNA NW remains intact over 24-h incubation in serum solution. Animal imaging and cell apoptosis show that the anticancer drugs formulated NW displays long blood-circulation time and high specificity in inducing cancer cell apoptosis. Treatment of tumor-bearing mice validates in vivo therapeutic efficacy, demonstrating an ideal theranostic vehicle for targeted imaging and therapy of cancers.

Authors+Show Affiliations

Fuzhou University, College of Chemistry, CHINA.Hunan University of Arts and Science, Chemistry and Materials Engineering, No. 3150, Dongting Avenue, 415000, Changde, CHINA.Fuzhou University, College of Chemistry, CHINA.Fuzhou University, College of Chemistry, CHINA.University of Illinois, Chemistry, 600 South Mathews Ave., 61801, Urbana, UNITED STATES.Fuzhou University, College of Chemistry, CHINA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32613705

Citation

Xue, Chang, et al. "Periodically Ordered, Nuclease-Resistant DNA Nanowires Decorated With Cell-Specific Aptamers as Selective Theranostic Agents." Angewandte Chemie (International Ed. in English), 2020.
Xue C, Zhang S, Yu X, et al. Periodically Ordered, Nuclease-Resistant DNA Nanowires Decorated with Cell-Specific Aptamers as Selective Theranostic Agents. Angew Chem Int Ed Engl. 2020.
Xue, C., Zhang, S., Yu, X., Hu, S., Lu, Y., & Wu, Z. S. (2020). Periodically Ordered, Nuclease-Resistant DNA Nanowires Decorated with Cell-Specific Aptamers as Selective Theranostic Agents. Angewandte Chemie (International Ed. in English). https://doi.org/10.1002/anie.202004805
Xue C, et al. Periodically Ordered, Nuclease-Resistant DNA Nanowires Decorated With Cell-Specific Aptamers as Selective Theranostic Agents. Angew Chem Int Ed Engl. 2020 Jul 2; PubMed PMID: 32613705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periodically Ordered, Nuclease-Resistant DNA Nanowires Decorated with Cell-Specific Aptamers as Selective Theranostic Agents. AU - Xue,Chang, AU - Zhang,Songbai, AU - Yu,Xin, AU - Hu,Shuyao, AU - Lu,Yi, AU - Wu,Zai-Sheng, Y1 - 2020/07/02/ PY - 2020/04/04/received PY - 2020/06/30/accepted PY - 2020/06/29/revised PY - 2020/7/3/entrez KW - periodically-ordered nick-hidden DNA nanowire KW - protective hairpin protrusion shell KW - standing-up aptamer KW - targeted drug delivery JF - Angewandte Chemie (International ed. in English) JO - Angew. Chem. Int. Ed. Engl. N2 - DNA nanostructures have shown potentials in cancer therapy. However, current clinical practice is hampered by the difficulty to deliver them into cancer cells and susceptibility to nuclease degradation. To overcome these limitations, we report herein a periodically-ordered nick-hidden DNA nanowire (NW) with high serum stability and active targeting functionality. The inner core is made of multiple-connected DNA double helices and the outer shell is composed of regularly-arranged standing-up hairpin aptamers. All terminals of the components are hidden from nuclease attacks while the target-binding sites are exposed to allow delivery to the cancer target. The DNA NW remains intact over 24-h incubation in serum solution. Animal imaging and cell apoptosis show that the anticancer drugs formulated NW displays long blood-circulation time and high specificity in inducing cancer cell apoptosis. Treatment of tumor-bearing mice validates in vivo therapeutic efficacy, demonstrating an ideal theranostic vehicle for targeted imaging and therapy of cancers. SN - 1521-3773 UR - https://www.unboundmedicine.com/medline/citation/32613705/Periodically_Ordered,_Nuclease-Resistant_DNA_Nanowires_Decorated_with_Cell-Specific_Aptamers_as_Selective_Theranostic_Agents L2 - https://doi.org/10.1002/anie.202004805 DB - PRIME DP - Unbound Medicine ER -
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