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Periorbital lipogranuloma after facial injection of autologous fat: A retrospective study of 18 cases.
Eur J Ophthalmol. 2020 Jul 02 [Online ahead of print]EJ

Abstract

OBJECTIVE

To investigate the clinical features of patients who develop periorbital lipogranuloma after injection of autologous fat.

METHODS

This retrospective case series included 18 patients who developed a periorbital mass or swelling after undergoing injection of autologous fat for facial augmentation. The patients' medical records were reviewed for clinical history, radiologic findings, and treatment outcomes.

RESULTS

All patients were women aged 24 to 50 years (mean, 31.6 years). Five patients (27.8%) involved both orbits. Presenting eye symptoms were a palpable mass (61.1%), eyelid swelling (44.4%), and ptosis (16.7%). The interval between the final injection and onset of eye symptoms ranged from 1 to 36 months (mean, 11.5 months). Thirteen patients underwent radiologic imaging. Fifteen patients received only one injection of autologous fat and three received two injections with the cryopreserved fat used in the second injection. Surgical excision was performed in 12 patients to remove the mass and identify the pathologic abnormalities. No recurrence was found during 1 year of follow-up. Two of the six patients who had refused treatment showed spontaneous resolution at the 6-month visit.

CONCLUSION

Periorbital lipogranuloma after facial injection of autologous fat should be considered as a specific orbital disease entity for which MRI is an effective examination method. Surgery is warranted for this condition when conservative treatment is ineffective.

Authors+Show Affiliations

Department of Ophthalmology, Mem Dinghui Hospital, Beijing, China.Department of Ophthalmology, Wuhan Fourth Hospital, Wuhan, China.Department of Ophthalmology, Institute of Orbital Diseases, The Third Medical Center of PLA General Hospital, Beijing, China.Department of Pathology, Institute of Orbital Diseases, The Third Medical Center of PLA General Hospital, Beijing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32613849

Citation

Yu, Xiuting, et al. "Periorbital Lipogranuloma After Facial Injection of Autologous Fat: a Retrospective Study of 18 Cases." European Journal of Ophthalmology, 2020, p. 1120672120938574.
Yu X, Yan H, Xiao L, et al. Periorbital lipogranuloma after facial injection of autologous fat: A retrospective study of 18 cases. Eur J Ophthalmol. 2020.
Yu, X., Yan, H., Xiao, L., & Hei, Y. (2020). Periorbital lipogranuloma after facial injection of autologous fat: A retrospective study of 18 cases. European Journal of Ophthalmology, 1120672120938574. https://doi.org/10.1177/1120672120938574
Yu X, et al. Periorbital Lipogranuloma After Facial Injection of Autologous Fat: a Retrospective Study of 18 Cases. Eur J Ophthalmol. 2020 Jul 2;1120672120938574. PubMed PMID: 32613849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periorbital lipogranuloma after facial injection of autologous fat: A retrospective study of 18 cases. AU - Yu,Xiuting, AU - Yan,Huan, AU - Xiao,Lihua, AU - Hei,Yan, Y1 - 2020/07/02/ PY - 2020/7/3/entrez KW - Lipogranuloma KW - autologous fat KW - facial fat injection KW - periorbital mass SP - 1120672120938574 EP - 1120672120938574 JF - European journal of ophthalmology JO - Eur J Ophthalmol N2 - OBJECTIVE: To investigate the clinical features of patients who develop periorbital lipogranuloma after injection of autologous fat. METHODS: This retrospective case series included 18 patients who developed a periorbital mass or swelling after undergoing injection of autologous fat for facial augmentation. The patients' medical records were reviewed for clinical history, radiologic findings, and treatment outcomes. RESULTS: All patients were women aged 24 to 50 years (mean, 31.6 years). Five patients (27.8%) involved both orbits. Presenting eye symptoms were a palpable mass (61.1%), eyelid swelling (44.4%), and ptosis (16.7%). The interval between the final injection and onset of eye symptoms ranged from 1 to 36 months (mean, 11.5 months). Thirteen patients underwent radiologic imaging. Fifteen patients received only one injection of autologous fat and three received two injections with the cryopreserved fat used in the second injection. Surgical excision was performed in 12 patients to remove the mass and identify the pathologic abnormalities. No recurrence was found during 1 year of follow-up. Two of the six patients who had refused treatment showed spontaneous resolution at the 6-month visit. CONCLUSION: Periorbital lipogranuloma after facial injection of autologous fat should be considered as a specific orbital disease entity for which MRI is an effective examination method. Surgery is warranted for this condition when conservative treatment is ineffective. SN - 1724-6016 UR - https://www.unboundmedicine.com/medline/citation/32613849/Periorbital_lipogranuloma_after_facial_injection_of_autologous_fat:_A_retrospective_study_of_18_cases L2 - https://journals.sagepub.com/doi/10.1177/1120672120938574?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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